Small bowel protection against NSAID-injury in rats: Effect of rifaximin, a poorly absorbed, GI targeted, antibiotic

[Display omitted] Nonsteroidal anti-inflammatory drugs, besides exerting detrimental effects on the upper digestive tract, can also damage the small and large intestine. Although the underlying mechanisms remain unclear, there is evidence that enteric bacteria play a pivotal role. The present study...

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Veröffentlicht in:	Pharmacological research 2016-02, Vol.104, p.186-196
Hauptverfasser:	Fornai, Matteo, Antonioli, Luca, Pellegrini, Carolina, Colucci, Rocchina, Sacco, Deborah, Tirotta, Erika, Natale, Gianfranco, Bartalucci, Alessia, Flaibani, Marina, Renzulli, Cecilia, Ghelardi, Emilia, Blandizzi, Corrado, Scarpignato, Carmelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - adverse effects Bacterial flora DNA, Bacterial - analysis Enteroprotection Firmicutes - isolation & purification Ileum - drug effects Ileum - metabolism Ileum - microbiology Ileum - pathology Indomethacin - adverse effects Intestinal Absorption Intestinal bleeding Intestinal damage Intestinal Diseases - drug therapy Intestinal Diseases - metabolism Intestinal Diseases - microbiology Intestinal Diseases - pathology Jejunum - drug effects Jejunum - metabolism Jejunum - microbiology Jejunum - pathology Male Malondialdehyde - metabolism Nonsteroidal anti-inflammatory drugs Peroxidase - metabolism Proteobacteria - isolation & purification Rats, Wistar Rifamycins - pharmacology Rifamycins - therapeutic use Rifaximin Tumor Necrosis Factor-alpha - metabolism
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