In vivo comparison of xenoestrogens using rainbow trout vitellogenin induction as a screening system
Vitellogenin induction in rainbow trout after intraperitoneal injection of test compounds was investigated. Vitellogenin quantification was performed by a direct sandwich enzyme‐linked immunosorbant assay (ELISA) based on polyclonal, affinity purified antibodies. The system was used as a short‐term...
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| Veröffentlicht in: | Environmental toxicology and chemistry 2000-07, Vol.19 (7), p.1867-1874 |
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| container_title | Environmental toxicology and chemistry |
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| creator | Christiansen, Lisette B. Pedersen, Knud L. Pedersen, Søren N. Korsgaard, Bodil Bjerregaard, Poul |
| description | Vitellogenin induction in rainbow trout after intraperitoneal injection of test compounds was investigated. Vitellogenin quantification was performed by a direct sandwich enzyme‐linked immunosorbant assay (ELISA) based on polyclonal, affinity purified antibodies. The system was used as a short‐term in vivo screen for estrogenicity and as a tool for establishing the priority of compounds to be tested by water exposure of fish. Representatives from the group of xenoestrogens, bisphenols, phthalates, and pesticides were tested. The relative potency order bisphenol A > bisphenol A dimethacrylate, o,p′‐DDT > butylbenzylphthalate was established, while no significant vitellogenin response was seen with dibutylphthalate, tetrabromobisphenol A, and methoxychlor. Of these, tetrabromobisphenol A has not previously been tested for estrogenicity in vivo. Earlier findings of diminished estrogenic activity of ortho‐substituted compounds was extended to bisphenols since ortho‐bromination of bisphenol A abolished the activity of the parent molecule. |
| doi_str_mv | 10.1002/etc.5620190721 |
| format | Article |
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Vitellogenin quantification was performed by a direct sandwich enzyme‐linked immunosorbant assay (ELISA) based on polyclonal, affinity purified antibodies. The system was used as a short‐term in vivo screen for estrogenicity and as a tool for establishing the priority of compounds to be tested by water exposure of fish. Representatives from the group of xenoestrogens, bisphenols, phthalates, and pesticides were tested. The relative potency order bisphenol A > bisphenol A dimethacrylate, o,p′‐DDT > butylbenzylphthalate was established, while no significant vitellogenin response was seen with dibutylphthalate, tetrabromobisphenol A, and methoxychlor. Of these, tetrabromobisphenol A has not previously been tested for estrogenicity in vivo. Earlier findings of diminished estrogenic activity of ortho‐substituted compounds was extended to bisphenols since ortho‐bromination of bisphenol A abolished the activity of the parent molecule.</description><identifier>ISSN: 0730-7268</identifier><identifier>EISSN: 1552-8618</identifier><identifier>DOI: 10.1002/etc.5620190721</identifier><identifier>CODEN: ETOCDK</identifier><language>eng</language><publisher>Hoboken: Wiley Periodicals, Inc</publisher><subject>Agnatha. Pisces ; Animal, plant and microbial ecology ; Applied ecology ; Biological and medical sciences ; Bisphenol ; bisphenol A ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Enzyme-linked immunosorbant assays ; Freshwater ; Fundamental and applied biological sciences. Psychology ; Oncorhynchus mykiss ; Pesticide ; Phthalate ; phthalates ; phthalic acid ; Rainbow trout ; vitellogenin ; xenoestrogens</subject><ispartof>Environmental toxicology and chemistry, 2000-07, Vol.19 (7), p.1867-1874</ispartof><rights>Copyright © 2000 SETAC</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4821-b8493db8b6f21a5543719d27f27c1bbc2e28baf302fe20ccbe8a58214c528f083</citedby><cites>FETCH-LOGICAL-c4821-b8493db8b6f21a5543719d27f27c1bbc2e28baf302fe20ccbe8a58214c528f083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fetc.5620190721$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fetc.5620190721$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1434990$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Christiansen, Lisette B.</creatorcontrib><creatorcontrib>Pedersen, Knud L.</creatorcontrib><creatorcontrib>Pedersen, Søren N.</creatorcontrib><creatorcontrib>Korsgaard, Bodil</creatorcontrib><creatorcontrib>Bjerregaard, Poul</creatorcontrib><title>In vivo comparison of xenoestrogens using rainbow trout vitellogenin induction as a screening system</title><title>Environmental toxicology and chemistry</title><addtitle>Environmental Toxicology and Chemistry</addtitle><description>Vitellogenin induction in rainbow trout after intraperitoneal injection of test compounds was investigated. Vitellogenin quantification was performed by a direct sandwich enzyme‐linked immunosorbant assay (ELISA) based on polyclonal, affinity purified antibodies. The system was used as a short‐term in vivo screen for estrogenicity and as a tool for establishing the priority of compounds to be tested by water exposure of fish. Representatives from the group of xenoestrogens, bisphenols, phthalates, and pesticides were tested. The relative potency order bisphenol A > bisphenol A dimethacrylate, o,p′‐DDT > butylbenzylphthalate was established, while no significant vitellogenin response was seen with dibutylphthalate, tetrabromobisphenol A, and methoxychlor. Of these, tetrabromobisphenol A has not previously been tested for estrogenicity in vivo. Earlier findings of diminished estrogenic activity of ortho‐substituted compounds was extended to bisphenols since ortho‐bromination of bisphenol A abolished the activity of the parent molecule.</description><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Bisphenol</subject><subject>bisphenol A</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Enzyme-linked immunosorbant assays</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Oncorhynchus mykiss</subject><subject>Pesticide</subject><subject>Phthalate</subject><subject>phthalates</subject><subject>phthalic acid</subject><subject>Rainbow trout</subject><subject>vitellogenin</subject><subject>xenoestrogens</subject><issn>0730-7268</issn><issn>1552-8618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkM1PGzEQxa2qSKTAlbMPVW-b2l57bR8r2lIkRAXiQ-JieR07cruxU88ukP--DkFFPXEaaeb93jw9hI4pmVNC2Gc_urnoGKGaSEbfoRkVgjWqo-o9mhHZkkayTu2jDwC_CKGd1nqGFmcJP8SHjF1erW2JkBPOAT_5lD2MJS99AjxBTEtcbEx9fsR1O40VGv0wbO8x4ZgWkxtjZS1gi8EVv90vMWxg9KtDtBfsAP7oZR6gm-_frk9-NOc_T89Ovpw3jitGm15x3S561XeBUSsEbyXVCyYDk472vWOeqd6GlrDgGXGu98qKCnInmApEtQfo0853XfKfqeY3qwiuxrTJ5wkMlZ0UnSZvC7ngkmlehfOd0JUMUHww6xJXtmwMJWbbuqmtm9fWK_DxxdmCs0MoNrkIrxRvuX4OoHeyxzj4zRumpir_e9Hs2Fi7ffrH2vLbdLKVwtxdnBpCbgW7_3plLtu_Pzmjpw</recordid><startdate>200007</startdate><enddate>200007</enddate><creator>Christiansen, Lisette B.</creator><creator>Pedersen, Knud L.</creator><creator>Pedersen, Søren N.</creator><creator>Korsgaard, Bodil</creator><creator>Bjerregaard, Poul</creator><general>Wiley Periodicals, Inc</general><general>SETAC</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7TV</scope><scope>7U7</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>200007</creationdate><title>In vivo comparison of xenoestrogens using rainbow trout vitellogenin induction as a screening system</title><author>Christiansen, Lisette B. ; Pedersen, Knud L. ; Pedersen, Søren N. ; Korsgaard, Bodil ; Bjerregaard, Poul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4821-b8493db8b6f21a5543719d27f27c1bbc2e28baf302fe20ccbe8a58214c528f083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Bisphenol</topic><topic>bisphenol A</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Enzyme-linked immunosorbant assays</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Oncorhynchus mykiss</topic><topic>Pesticide</topic><topic>Phthalate</topic><topic>phthalates</topic><topic>phthalic acid</topic><topic>Rainbow trout</topic><topic>vitellogenin</topic><topic>xenoestrogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christiansen, Lisette B.</creatorcontrib><creatorcontrib>Pedersen, Knud L.</creatorcontrib><creatorcontrib>Pedersen, Søren N.</creatorcontrib><creatorcontrib>Korsgaard, Bodil</creatorcontrib><creatorcontrib>Bjerregaard, Poul</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Environmental toxicology and chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christiansen, Lisette B.</au><au>Pedersen, Knud L.</au><au>Pedersen, Søren N.</au><au>Korsgaard, Bodil</au><au>Bjerregaard, Poul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo comparison of xenoestrogens using rainbow trout vitellogenin induction as a screening system</atitle><jtitle>Environmental toxicology and chemistry</jtitle><addtitle>Environmental Toxicology and Chemistry</addtitle><date>2000-07</date><risdate>2000</risdate><volume>19</volume><issue>7</issue><spage>1867</spage><epage>1874</epage><pages>1867-1874</pages><issn>0730-7268</issn><eissn>1552-8618</eissn><coden>ETOCDK</coden><abstract>Vitellogenin induction in rainbow trout after intraperitoneal injection of test compounds was investigated. Vitellogenin quantification was performed by a direct sandwich enzyme‐linked immunosorbant assay (ELISA) based on polyclonal, affinity purified antibodies. The system was used as a short‐term in vivo screen for estrogenicity and as a tool for establishing the priority of compounds to be tested by water exposure of fish. Representatives from the group of xenoestrogens, bisphenols, phthalates, and pesticides were tested. The relative potency order bisphenol A > bisphenol A dimethacrylate, o,p′‐DDT > butylbenzylphthalate was established, while no significant vitellogenin response was seen with dibutylphthalate, tetrabromobisphenol A, and methoxychlor. Of these, tetrabromobisphenol A has not previously been tested for estrogenicity in vivo. Earlier findings of diminished estrogenic activity of ortho‐substituted compounds was extended to bisphenols since ortho‐bromination of bisphenol A abolished the activity of the parent molecule.</abstract><cop>Hoboken</cop><pub>Wiley Periodicals, Inc</pub><doi>10.1002/etc.5620190721</doi><tpages>8</tpages></addata></record> |
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| subjects | Agnatha. Pisces Animal, plant and microbial ecology Applied ecology Biological and medical sciences Bisphenol bisphenol A Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Enzyme-linked immunosorbant assays Freshwater Fundamental and applied biological sciences. Psychology Oncorhynchus mykiss Pesticide Phthalate phthalates phthalic acid Rainbow trout vitellogenin xenoestrogens |
| title | In vivo comparison of xenoestrogens using rainbow trout vitellogenin induction as a screening system |
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