Chronic toxicity of nonylphenol and ethinylestradiol: haematological and histopathological effects in juvenile Common carp ( Cyprinus carpio)
In recent ecotoxicological research, there is an increasing concern about alkylphenolic industrial chemicals, such as nonylphenol (NP), because of their estrogenic properties. Data on the general fish toxicity of these wide spread aquatic pollutants are scarce. In order to evaluate sublethal toxic e...
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| Veröffentlicht in: | Aquatic toxicology 2000-11, Vol.51 (1), p.69-78 |
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| creator | Schwaiger, J. Spieser, O.H Bauer, C. Ferling, H. Mallow, U. Kalbfus, W. Negele, R.D. |
| description | In recent ecotoxicological research, there is an increasing concern about alkylphenolic industrial chemicals, such as nonylphenol (NP), because of their estrogenic properties. Data on the general fish toxicity of these wide spread aquatic pollutants are scarce. In order to evaluate sublethal toxic effects of environmentally relevant concentrations of NP, juvenile Common carp (
Cyprinus carpio) were exposed to NP concentrations ranging from 1 to 15 μg NP/l over a 70-day period. Classical toxicological endpoints, such as various haematological parameters and histopathological alterations were investigated. In a comprehensive protocol, besides NP-induced effects also alterations due to a treatment with the synthetic estrogen ethinylestradiol (EE2) were evaluated. After both the NP-exposure as well as the EE2-treatment, the predominant haematological finding was a severe anaemia. Histopathological alterations in the kidney, the liver and the spleen occurred exclusively after treatment with EE2, whereas NP-exposed fish did not show any tissue lesions. Depending on the haematological parameter examined, a NOEC between 1 and 5 μg NP/l could be established. From the present findings, it is assumed, that under field conditions, the NP-induced, general toxic effects, might outbalance the relatively weak estrogenic effects of this compound and possibly might disturb ecologically relevant processes such as fish reproduction. |
| doi_str_mv | 10.1016/S0166-445X(00)00098-9 |
| format | Article |
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Cyprinus carpio) were exposed to NP concentrations ranging from 1 to 15 μg NP/l over a 70-day period. Classical toxicological endpoints, such as various haematological parameters and histopathological alterations were investigated. In a comprehensive protocol, besides NP-induced effects also alterations due to a treatment with the synthetic estrogen ethinylestradiol (EE2) were evaluated. After both the NP-exposure as well as the EE2-treatment, the predominant haematological finding was a severe anaemia. Histopathological alterations in the kidney, the liver and the spleen occurred exclusively after treatment with EE2, whereas NP-exposed fish did not show any tissue lesions. Depending on the haematological parameter examined, a NOEC between 1 and 5 μg NP/l could be established. From the present findings, it is assumed, that under field conditions, the NP-induced, general toxic effects, might outbalance the relatively weak estrogenic effects of this compound and possibly might disturb ecologically relevant processes such as fish reproduction.</description><identifier>ISSN: 0166-445X</identifier><identifier>EISSN: 1879-1514</identifier><identifier>DOI: 10.1016/S0166-445X(00)00098-9</identifier><identifier>PMID: 10998500</identifier><identifier>CODEN: AQTODG</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Agnatha. Pisces ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Blood Cell Count ; Carps - physiology ; Cyprinus carpio ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Endpoint Determination ; Erythrocyte Count ; Estradiol Congeners - toxicity ; ethinyl estradiol ; Ethinyl Estradiol - toxicity ; Ethinylestradiol ; ethynylestradiol ; Fish ; Freshwater ; Fundamental and applied biological sciences. Psychology ; Hemoglobins - metabolism ; Kidney - metabolism ; Kidney - pathology ; Liver - metabolism ; Liver - pathology ; Nonylphenol ; Phenols - toxicity ; Spleen - metabolism ; Spleen - pathology ; Toxicity</subject><ispartof>Aquatic toxicology, 2000-11, Vol.51 (1), p.69-78</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-7fcf81b702b3408a2a408db21ba31c079b07bf9d4ec1d7257a1cdfb380e546e93</citedby><cites>FETCH-LOGICAL-c452t-7fcf81b702b3408a2a408db21ba31c079b07bf9d4ec1d7257a1cdfb380e546e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0166-445X(00)00098-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1529758$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10998500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schwaiger, J.</creatorcontrib><creatorcontrib>Spieser, O.H</creatorcontrib><creatorcontrib>Bauer, C.</creatorcontrib><creatorcontrib>Ferling, H.</creatorcontrib><creatorcontrib>Mallow, U.</creatorcontrib><creatorcontrib>Kalbfus, W.</creatorcontrib><creatorcontrib>Negele, R.D.</creatorcontrib><title>Chronic toxicity of nonylphenol and ethinylestradiol: haematological and histopathological effects in juvenile Common carp ( Cyprinus carpio)</title><title>Aquatic toxicology</title><addtitle>Aquat Toxicol</addtitle><description>In recent ecotoxicological research, there is an increasing concern about alkylphenolic industrial chemicals, such as nonylphenol (NP), because of their estrogenic properties. Data on the general fish toxicity of these wide spread aquatic pollutants are scarce. In order to evaluate sublethal toxic effects of environmentally relevant concentrations of NP, juvenile Common carp (
Cyprinus carpio) were exposed to NP concentrations ranging from 1 to 15 μg NP/l over a 70-day period. Classical toxicological endpoints, such as various haematological parameters and histopathological alterations were investigated. In a comprehensive protocol, besides NP-induced effects also alterations due to a treatment with the synthetic estrogen ethinylestradiol (EE2) were evaluated. After both the NP-exposure as well as the EE2-treatment, the predominant haematological finding was a severe anaemia. Histopathological alterations in the kidney, the liver and the spleen occurred exclusively after treatment with EE2, whereas NP-exposed fish did not show any tissue lesions. Depending on the haematological parameter examined, a NOEC between 1 and 5 μg NP/l could be established. From the present findings, it is assumed, that under field conditions, the NP-induced, general toxic effects, might outbalance the relatively weak estrogenic effects of this compound and possibly might disturb ecologically relevant processes such as fish reproduction.</description><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Blood Cell Count</subject><subject>Carps - physiology</subject><subject>Cyprinus carpio</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Endpoint Determination</subject><subject>Erythrocyte Count</subject><subject>Estradiol Congeners - toxicity</subject><subject>ethinyl estradiol</subject><subject>Ethinyl Estradiol - toxicity</subject><subject>Ethinylestradiol</subject><subject>ethynylestradiol</subject><subject>Fish</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemoglobins - metabolism</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Nonylphenol</subject><subject>Phenols - toxicity</subject><subject>Spleen - metabolism</subject><subject>Spleen - pathology</subject><subject>Toxicity</subject><issn>0166-445X</issn><issn>1879-1514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2O1SAUgInRONfRR9CwMGZmUYUWSpmNMY1_ySQu1MQdofRgmbRQoZ14H8J3lnt7M7qbzSGcfHB-PoSeU_KaElq_-ZpDXTDGf1wQckkIkU0hH6AdbYQsKKfsIdrdIWfoSUo3GSIlk4_RGSVSNpyQHfrTDjF4Z_ASfjvjlj0OFvvg9-M8gA8j1r7HsAwuZyAtUfcujFd40DDpJYzhpzN6gwaXljDrZbjLgrVgloSdxzfrLXg3Am7DNAWPjY4zvsDtfo7Or-l4d-HyKXpk9Zjg2ek8R98_vP_Wfiquv3z83L67Lgzj5VIIa2xDO0HKrmKk0aXOse9K2umKGiJkR0RnZc_A0F6UXGhqettVDQHOapDVOXq1_TvH8GvNc6nJJQPjqD2ENSkqalFWkt0PMl6ziosM8g00MaQUwao82aTjXlGiDsLUUZg62FCEqKMwdejkxanA2k3Q__dqM5SBlydAp7xUG7U3Lv3jeCkFbzL2dsMgr-3WQVTJOPAGehezBNUHd08nfwGFY7Wy</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>Schwaiger, J.</creator><creator>Spieser, O.H</creator><creator>Bauer, C.</creator><creator>Ferling, H.</creator><creator>Mallow, U.</creator><creator>Kalbfus, W.</creator><creator>Negele, R.D.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7QH</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20001101</creationdate><title>Chronic toxicity of nonylphenol and ethinylestradiol: haematological and histopathological effects in juvenile Common carp ( Cyprinus carpio)</title><author>Schwaiger, J. ; Spieser, O.H ; Bauer, C. ; Ferling, H. ; Mallow, U. ; Kalbfus, W. ; Negele, R.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-7fcf81b702b3408a2a408db21ba31c079b07bf9d4ec1d7257a1cdfb380e546e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Blood Cell Count</topic><topic>Carps - physiology</topic><topic>Cyprinus carpio</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Endpoint Determination</topic><topic>Erythrocyte Count</topic><topic>Estradiol Congeners - toxicity</topic><topic>ethinyl estradiol</topic><topic>Ethinyl Estradiol - toxicity</topic><topic>Ethinylestradiol</topic><topic>ethynylestradiol</topic><topic>Fish</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemoglobins - metabolism</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Nonylphenol</topic><topic>Phenols - toxicity</topic><topic>Spleen - metabolism</topic><topic>Spleen - pathology</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schwaiger, J.</creatorcontrib><creatorcontrib>Spieser, O.H</creatorcontrib><creatorcontrib>Bauer, C.</creatorcontrib><creatorcontrib>Ferling, H.</creatorcontrib><creatorcontrib>Mallow, U.</creatorcontrib><creatorcontrib>Kalbfus, W.</creatorcontrib><creatorcontrib>Negele, R.D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Aqualine</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Aquatic toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwaiger, J.</au><au>Spieser, O.H</au><au>Bauer, C.</au><au>Ferling, H.</au><au>Mallow, U.</au><au>Kalbfus, W.</au><au>Negele, R.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic toxicity of nonylphenol and ethinylestradiol: haematological and histopathological effects in juvenile Common carp ( Cyprinus carpio)</atitle><jtitle>Aquatic toxicology</jtitle><addtitle>Aquat Toxicol</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>51</volume><issue>1</issue><spage>69</spage><epage>78</epage><pages>69-78</pages><issn>0166-445X</issn><eissn>1879-1514</eissn><coden>AQTODG</coden><abstract>In recent ecotoxicological research, there is an increasing concern about alkylphenolic industrial chemicals, such as nonylphenol (NP), because of their estrogenic properties. Data on the general fish toxicity of these wide spread aquatic pollutants are scarce. In order to evaluate sublethal toxic effects of environmentally relevant concentrations of NP, juvenile Common carp (
Cyprinus carpio) were exposed to NP concentrations ranging from 1 to 15 μg NP/l over a 70-day period. Classical toxicological endpoints, such as various haematological parameters and histopathological alterations were investigated. In a comprehensive protocol, besides NP-induced effects also alterations due to a treatment with the synthetic estrogen ethinylestradiol (EE2) were evaluated. After both the NP-exposure as well as the EE2-treatment, the predominant haematological finding was a severe anaemia. Histopathological alterations in the kidney, the liver and the spleen occurred exclusively after treatment with EE2, whereas NP-exposed fish did not show any tissue lesions. Depending on the haematological parameter examined, a NOEC between 1 and 5 μg NP/l could be established. From the present findings, it is assumed, that under field conditions, the NP-induced, general toxic effects, might outbalance the relatively weak estrogenic effects of this compound and possibly might disturb ecologically relevant processes such as fish reproduction.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>10998500</pmid><doi>10.1016/S0166-445X(00)00098-9</doi><tpages>10</tpages></addata></record> |
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| subjects | Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Blood Cell Count Carps - physiology Cyprinus carpio Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Endpoint Determination Erythrocyte Count Estradiol Congeners - toxicity ethinyl estradiol Ethinyl Estradiol - toxicity Ethinylestradiol ethynylestradiol Fish Freshwater Fundamental and applied biological sciences. Psychology Hemoglobins - metabolism Kidney - metabolism Kidney - pathology Liver - metabolism Liver - pathology Nonylphenol Phenols - toxicity Spleen - metabolism Spleen - pathology Toxicity |
| title | Chronic toxicity of nonylphenol and ethinylestradiol: haematological and histopathological effects in juvenile Common carp ( Cyprinus carpio) |
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