Familial skin cancer syndromes: Increased melanoma risk
Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melan...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 2016-03, Vol.74 (3), p.423-34; quiz 435-6 |
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| container_end_page | 34; quiz 435-6 |
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| container_issue | 3 |
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| container_title | Journal of the American Academy of Dermatology |
| container_volume | 74 |
| creator | Ransohoff, Katherine J Jaju, Prajakta D Jaju, Prajaka D Tang, Jean Y Carbone, Michele Leachman, Sancy Sarin, Kavita Y |
| description | Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings. |
| doi_str_mv | 10.1016/j.jaad.2015.09.070 |
| format | Article |
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| identifier | EISSN: 1097-6787 |
| ispartof | Journal of the American Academy of Dermatology, 2016-03, Vol.74 (3), p.423-34; quiz 435-6 |
| issn | 1097-6787 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Humans Melanoma - diagnosis Melanoma - epidemiology Melanoma - genetics Melanoma - therapy Neoplastic Syndromes, Hereditary - diagnosis Neoplastic Syndromes, Hereditary - epidemiology Neoplastic Syndromes, Hereditary - therapy Risk Skin Neoplasms - diagnosis Skin Neoplasms - epidemiology Skin Neoplasms - genetics Skin Neoplasms - therapy |
| title | Familial skin cancer syndromes: Increased melanoma risk |
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