A General Strategy for the Nickel-Catalyzed C−H Alkylation of Anilines

The C−H alkylation of aniline derivatives with both primary and secondary alkyl halides was achieved with a versatile nickel catalyst of a vicinal diamine ligand. Step‐economic access to functionalized 2‐pyrimidyl anilines, key structural motifs in anticancer drugs, is thus provided. The C−H functio...

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Veröffentlicht in:	Angewandte Chemie International Edition 2016-02, Vol.55 (9), p.3153-3157
Hauptverfasser:	Ruan, Zhixiong, Lackner, Sebastian, Ackermann, Lutz
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Aniline anilines Antineoplastic drugs Antitumor agents Catalysts C−H activation Drugs Halides Nickel reaction mechanisms
Online-Zugang:	Volltext
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