One-Pot Synthesis of Highly Substituted Nicotinic Acid Derivatives Based on a Formylation Strategy of Enamino Keto Esters

A facile one-pot synthesis of 4-chloro or 4-bromonicotinic acid esters with optional 2- and 2,5-disubstitution on the pyridine ring has been developed from easily accessible enamino keto esters by a formylation followed by in situ intramolecular cyclization strategy under optimized Vilsmeier reactio...

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Veröffentlicht in:	Journal of organic chemistry 2016-02, Vol.81 (4), p.1645-1653
Hauptverfasser:	Kumar, Sukeerthi, Sawant, Aarti A, Chikhale, Rajendra P, Karanjai, Keya, Thomas, Abraham
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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