FK506 regulates pigmentation by maturing the melanosome and facilitating their transfer to keratinocytes

Summary Despite the clinical ability of topical tacrolimus (FK506) to effectively promote repigmentation in vitiligo, the underlying mechanism through which FK506 regulates melanogenesis was previously unclear. We found that FK506 treatment increased the melanin contents (especially that of eumelani...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pigment cell and melanoma research 2016-03, Vol.29 (2), p.199-209
Hauptverfasser:	Jung, Hyejung, Chung, Heesung, Chang, Sung Eun, Kang, Duk-Hee, Oh, Eok-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport, Active - drug effects Biological Transport, Active - radiation effects Cell Line, Tumor FK506 HEK293 Cells Humans Keratinocytes - metabolism Keratinocytes - ultrastructure Melanins - metabolism melano-some melanogenesis Melanosomes - metabolism Melanosomes - ultrastructure Mice Skin Pigmentation - drug effects Skin Pigmentation - radiation effects Tacrolimus - pharmacology tyrosinase Ultraviolet Rays vitiligo
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!