LOX-1 gene variants and maternal levels of plasma oxidized LDL and malondialdehyde in patients with gestational diabetes mellitus
Purpose The aim of this study was to investigate the relationships between the maternal levels of oxidized LDL (ox-LDL), lipid peroxidation marker malondialdehyde (MDA) and LOX-1 3′UTR188C/T and K167N single nucleotide polymorphisms in pregnant Turkish women with gestational diabetes mellitus (GDM)....
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2016-03, Vol.293 (3), p.517-527 |
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| creator | Aydemir, Birsen Baykara, Onur Cinemre, Fatma Behice Serinkan Cinemre, Hakan Tuten, Abdullah Kiziler, Ali Riza Akdemir, Nermin Oncul, Mahmut Kaya, Baris Sozer, Volkan Erkorkmaz, Unal Uzun, Hafize |
| description | Purpose
The aim of this study was to investigate the relationships between the maternal levels of oxidized LDL (ox-LDL), lipid peroxidation marker malondialdehyde (MDA) and LOX-1 3′UTR188C/T and K167N single nucleotide polymorphisms in pregnant Turkish women with gestational diabetes mellitus (GDM).
Methods
116 pregnant women with GDM and 120 healthy pregnant women from the same geographic region were included in the study. Polymerase chain reaction-based restriction analysis was used to identify 3′UTR188C/T and K167N polymorphisms of the LOX-1 gene. Plasma ox-LDL and MDA levels were determined by enzyme-linked immunosorbent assay and spectrophotometric method in all study subjects, respectively.
Results
Our results indicated that the distribution of the LOX-1 3′UTR188C/T and K167N genotypes and alleles did not differ significantly among subjects with or without GDM (
p
> 0.05). TT and NN genotype carriers are associated with some glucose metabolism parameters (
p
0.05). According to the combined genotype analysis of LOX-1 3′UTR 188 TT and K167N NN polymorphisms, plasma MDA and ox-LDL levels were significantly different between women with GDM and healthy subjects either with or without combined TT/NN genotype carriers (
p
|
| doi_str_mv | 10.1007/s00404-015-3851-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1767071515</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1767071515</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-c4d7f78b85f48adee7b7d20d60316ce797bcb4895b8ec63a8a24190a2b07da793</originalsourceid><addsrcrecordid>eNp1kc1u1TAQRi0EopfCA7BBltiwCR07ju0sUfmVInVDpe6sSTxpXTnJJU4KZceb4-heQELqxrbsM8ej-Rh7KeCtADBnCUCBKkBURWkrUehHbCdUKQswQjxmO6i3M2hzwp6ldAsgpLX6KTuRWta6VmLHfjUXV4Xg1zQSv8M54LgkjqPnAy40jxh5pDuKiU8930dMA_LpR_DhJ3nevG-OaJxGHzB6urn3xMPI97gE2lTfw3KT7WnJF9Omy1xLCyU-UIxhWdNz9qTHmOjFcT9llx8_fD3_XDQXn76cv2uKTim55NWb3tjWVr2y6IlMa7wEr6EUuiNTm7Zrla2r1lKnS7QolagBZQvGo6nLU_bm4N3P07c1d-SGkLrcBI40rckJo02eWyWqjL7-D72d1m0YyUmpRSVVCTZT4kB185TSTL3bz2HA-d4JcFs-7pCPy_m4LR-nc82ro3ltB_J_K_4EkgF5AFJ-Gq9p_vf1w9bfVJebzw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261524308</pqid></control><display><type>article</type><title>LOX-1 gene variants and maternal levels of plasma oxidized LDL and malondialdehyde in patients with gestational diabetes mellitus</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Aydemir, Birsen ; Baykara, Onur ; Cinemre, Fatma Behice Serinkan ; Cinemre, Hakan ; Tuten, Abdullah ; Kiziler, Ali Riza ; Akdemir, Nermin ; Oncul, Mahmut ; Kaya, Baris ; Sozer, Volkan ; Erkorkmaz, Unal ; Uzun, Hafize</creator><creatorcontrib>Aydemir, Birsen ; Baykara, Onur ; Cinemre, Fatma Behice Serinkan ; Cinemre, Hakan ; Tuten, Abdullah ; Kiziler, Ali Riza ; Akdemir, Nermin ; Oncul, Mahmut ; Kaya, Baris ; Sozer, Volkan ; Erkorkmaz, Unal ; Uzun, Hafize</creatorcontrib><description>Purpose
The aim of this study was to investigate the relationships between the maternal levels of oxidized LDL (ox-LDL), lipid peroxidation marker malondialdehyde (MDA) and LOX-1 3′UTR188C/T and K167N single nucleotide polymorphisms in pregnant Turkish women with gestational diabetes mellitus (GDM).
Methods
116 pregnant women with GDM and 120 healthy pregnant women from the same geographic region were included in the study. Polymerase chain reaction-based restriction analysis was used to identify 3′UTR188C/T and K167N polymorphisms of the LOX-1 gene. Plasma ox-LDL and MDA levels were determined by enzyme-linked immunosorbent assay and spectrophotometric method in all study subjects, respectively.
Results
Our results indicated that the distribution of the LOX-1 3′UTR188C/T and K167N genotypes and alleles did not differ significantly among subjects with or without GDM (
p
> 0.05). TT and NN genotype carriers are associated with some glucose metabolism parameters (
p
< 0.05). There were no significant differences among plasma ox-LDL and MDA levels with regard to LOX-1 3′UTR188C/T and K167N polymorphisms in GDM group and control subjects (
p
> 0.05). According to the combined genotype analysis of LOX-1 3′UTR 188 TT and K167N NN polymorphisms, plasma MDA and ox-LDL levels were significantly different between women with GDM and healthy subjects either with or without combined TT/NN genotype carriers (
p
< 0.001).
Conclusions
According to our results, ox-LDL and MDA levels were increased in GDM pregnant women and healthy pregnant women either with or without combined TT/NN genotype carriers, for our Turkish sample, these genotype carriers appear to be related with increased oxidative stress in patients with GDM.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-015-3851-6</identifier><identifier>PMID: 26296941</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>3' Untranslated Regions - genetics ; Adult ; Alleles ; Case-Control Studies ; Diabetes ; Diabetes, Gestational - blood ; Diabetes, Gestational - ethnology ; Diabetes, Gestational - genetics ; Endocrinology ; Enzyme-Linked Immunosorbent Assay ; Female ; Genotype ; Genotype & phenotype ; Gynecology ; Heterozygote ; Human Genetics ; Humans ; Lipoproteins, LDL - blood ; Malondialdehyde - blood ; Maternal Serum Screening Tests ; Maternal-Fetal Medicine ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Oxidation ; Plasma ; Polymorphism, Restriction Fragment Length - genetics ; Polymorphism, Single Nucleotide ; Pregnancy ; Scavenger Receptors, Class E - blood ; Scavenger Receptors, Class E - genetics ; Spectrophotometry ; Turkey</subject><ispartof>Archives of gynecology and obstetrics, 2016-03, Vol.293 (3), p.517-527</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2015). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-c4d7f78b85f48adee7b7d20d60316ce797bcb4895b8ec63a8a24190a2b07da793</citedby><cites>FETCH-LOGICAL-c442t-c4d7f78b85f48adee7b7d20d60316ce797bcb4895b8ec63a8a24190a2b07da793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-015-3851-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-015-3851-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26296941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aydemir, Birsen</creatorcontrib><creatorcontrib>Baykara, Onur</creatorcontrib><creatorcontrib>Cinemre, Fatma Behice Serinkan</creatorcontrib><creatorcontrib>Cinemre, Hakan</creatorcontrib><creatorcontrib>Tuten, Abdullah</creatorcontrib><creatorcontrib>Kiziler, Ali Riza</creatorcontrib><creatorcontrib>Akdemir, Nermin</creatorcontrib><creatorcontrib>Oncul, Mahmut</creatorcontrib><creatorcontrib>Kaya, Baris</creatorcontrib><creatorcontrib>Sozer, Volkan</creatorcontrib><creatorcontrib>Erkorkmaz, Unal</creatorcontrib><creatorcontrib>Uzun, Hafize</creatorcontrib><title>LOX-1 gene variants and maternal levels of plasma oxidized LDL and malondialdehyde in patients with gestational diabetes mellitus</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
The aim of this study was to investigate the relationships between the maternal levels of oxidized LDL (ox-LDL), lipid peroxidation marker malondialdehyde (MDA) and LOX-1 3′UTR188C/T and K167N single nucleotide polymorphisms in pregnant Turkish women with gestational diabetes mellitus (GDM).
Methods
116 pregnant women with GDM and 120 healthy pregnant women from the same geographic region were included in the study. Polymerase chain reaction-based restriction analysis was used to identify 3′UTR188C/T and K167N polymorphisms of the LOX-1 gene. Plasma ox-LDL and MDA levels were determined by enzyme-linked immunosorbent assay and spectrophotometric method in all study subjects, respectively.
Results
Our results indicated that the distribution of the LOX-1 3′UTR188C/T and K167N genotypes and alleles did not differ significantly among subjects with or without GDM (
p
> 0.05). TT and NN genotype carriers are associated with some glucose metabolism parameters (
p
< 0.05). There were no significant differences among plasma ox-LDL and MDA levels with regard to LOX-1 3′UTR188C/T and K167N polymorphisms in GDM group and control subjects (
p
> 0.05). According to the combined genotype analysis of LOX-1 3′UTR 188 TT and K167N NN polymorphisms, plasma MDA and ox-LDL levels were significantly different between women with GDM and healthy subjects either with or without combined TT/NN genotype carriers (
p
< 0.001).
Conclusions
According to our results, ox-LDL and MDA levels were increased in GDM pregnant women and healthy pregnant women either with or without combined TT/NN genotype carriers, for our Turkish sample, these genotype carriers appear to be related with increased oxidative stress in patients with GDM.</description><subject>3' Untranslated Regions - genetics</subject><subject>Adult</subject><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Diabetes</subject><subject>Diabetes, Gestational - blood</subject><subject>Diabetes, Gestational - ethnology</subject><subject>Diabetes, Gestational - genetics</subject><subject>Endocrinology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Gynecology</subject><subject>Heterozygote</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Lipoproteins, LDL - blood</subject><subject>Malondialdehyde - blood</subject><subject>Maternal Serum Screening Tests</subject><subject>Maternal-Fetal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Oxidation</subject><subject>Plasma</subject><subject>Polymorphism, Restriction Fragment Length - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pregnancy</subject><subject>Scavenger Receptors, Class E - blood</subject><subject>Scavenger Receptors, Class E - genetics</subject><subject>Spectrophotometry</subject><subject>Turkey</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc1u1TAQRi0EopfCA7BBltiwCR07ju0sUfmVInVDpe6sSTxpXTnJJU4KZceb4-heQELqxrbsM8ej-Rh7KeCtADBnCUCBKkBURWkrUehHbCdUKQswQjxmO6i3M2hzwp6ldAsgpLX6KTuRWta6VmLHfjUXV4Xg1zQSv8M54LgkjqPnAy40jxh5pDuKiU8930dMA_LpR_DhJ3nevG-OaJxGHzB6urn3xMPI97gE2lTfw3KT7WnJF9Omy1xLCyU-UIxhWdNz9qTHmOjFcT9llx8_fD3_XDQXn76cv2uKTim55NWb3tjWVr2y6IlMa7wEr6EUuiNTm7Zrla2r1lKnS7QolagBZQvGo6nLU_bm4N3P07c1d-SGkLrcBI40rckJo02eWyWqjL7-D72d1m0YyUmpRSVVCTZT4kB185TSTL3bz2HA-d4JcFs-7pCPy_m4LR-nc82ro3ltB_J_K_4EkgF5AFJ-Gq9p_vf1w9bfVJebzw</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Aydemir, Birsen</creator><creator>Baykara, Onur</creator><creator>Cinemre, Fatma Behice Serinkan</creator><creator>Cinemre, Hakan</creator><creator>Tuten, Abdullah</creator><creator>Kiziler, Ali Riza</creator><creator>Akdemir, Nermin</creator><creator>Oncul, Mahmut</creator><creator>Kaya, Baris</creator><creator>Sozer, Volkan</creator><creator>Erkorkmaz, Unal</creator><creator>Uzun, Hafize</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160301</creationdate><title>LOX-1 gene variants and maternal levels of plasma oxidized LDL and malondialdehyde in patients with gestational diabetes mellitus</title><author>Aydemir, Birsen ; Baykara, Onur ; Cinemre, Fatma Behice Serinkan ; Cinemre, Hakan ; Tuten, Abdullah ; Kiziler, Ali Riza ; Akdemir, Nermin ; Oncul, Mahmut ; Kaya, Baris ; Sozer, Volkan ; Erkorkmaz, Unal ; Uzun, Hafize</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-c4d7f78b85f48adee7b7d20d60316ce797bcb4895b8ec63a8a24190a2b07da793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>3' Untranslated Regions - genetics</topic><topic>Adult</topic><topic>Alleles</topic><topic>Case-Control Studies</topic><topic>Diabetes</topic><topic>Diabetes, Gestational - blood</topic><topic>Diabetes, Gestational - ethnology</topic><topic>Diabetes, Gestational - genetics</topic><topic>Endocrinology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Gynecology</topic><topic>Heterozygote</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Lipoproteins, LDL - blood</topic><topic>Malondialdehyde - blood</topic><topic>Maternal Serum Screening Tests</topic><topic>Maternal-Fetal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Oxidation</topic><topic>Plasma</topic><topic>Polymorphism, Restriction Fragment Length - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pregnancy</topic><topic>Scavenger Receptors, Class E - blood</topic><topic>Scavenger Receptors, Class E - genetics</topic><topic>Spectrophotometry</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aydemir, Birsen</creatorcontrib><creatorcontrib>Baykara, Onur</creatorcontrib><creatorcontrib>Cinemre, Fatma Behice Serinkan</creatorcontrib><creatorcontrib>Cinemre, Hakan</creatorcontrib><creatorcontrib>Tuten, Abdullah</creatorcontrib><creatorcontrib>Kiziler, Ali Riza</creatorcontrib><creatorcontrib>Akdemir, Nermin</creatorcontrib><creatorcontrib>Oncul, Mahmut</creatorcontrib><creatorcontrib>Kaya, Baris</creatorcontrib><creatorcontrib>Sozer, Volkan</creatorcontrib><creatorcontrib>Erkorkmaz, Unal</creatorcontrib><creatorcontrib>Uzun, Hafize</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aydemir, Birsen</au><au>Baykara, Onur</au><au>Cinemre, Fatma Behice Serinkan</au><au>Cinemre, Hakan</au><au>Tuten, Abdullah</au><au>Kiziler, Ali Riza</au><au>Akdemir, Nermin</au><au>Oncul, Mahmut</au><au>Kaya, Baris</au><au>Sozer, Volkan</au><au>Erkorkmaz, Unal</au><au>Uzun, Hafize</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LOX-1 gene variants and maternal levels of plasma oxidized LDL and malondialdehyde in patients with gestational diabetes mellitus</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>293</volume><issue>3</issue><spage>517</spage><epage>527</epage><pages>517-527</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
The aim of this study was to investigate the relationships between the maternal levels of oxidized LDL (ox-LDL), lipid peroxidation marker malondialdehyde (MDA) and LOX-1 3′UTR188C/T and K167N single nucleotide polymorphisms in pregnant Turkish women with gestational diabetes mellitus (GDM).
Methods
116 pregnant women with GDM and 120 healthy pregnant women from the same geographic region were included in the study. Polymerase chain reaction-based restriction analysis was used to identify 3′UTR188C/T and K167N polymorphisms of the LOX-1 gene. Plasma ox-LDL and MDA levels were determined by enzyme-linked immunosorbent assay and spectrophotometric method in all study subjects, respectively.
Results
Our results indicated that the distribution of the LOX-1 3′UTR188C/T and K167N genotypes and alleles did not differ significantly among subjects with or without GDM (
p
> 0.05). TT and NN genotype carriers are associated with some glucose metabolism parameters (
p
< 0.05). There were no significant differences among plasma ox-LDL and MDA levels with regard to LOX-1 3′UTR188C/T and K167N polymorphisms in GDM group and control subjects (
p
> 0.05). According to the combined genotype analysis of LOX-1 3′UTR 188 TT and K167N NN polymorphisms, plasma MDA and ox-LDL levels were significantly different between women with GDM and healthy subjects either with or without combined TT/NN genotype carriers (
p
< 0.001).
Conclusions
According to our results, ox-LDL and MDA levels were increased in GDM pregnant women and healthy pregnant women either with or without combined TT/NN genotype carriers, for our Turkish sample, these genotype carriers appear to be related with increased oxidative stress in patients with GDM.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26296941</pmid><doi>10.1007/s00404-015-3851-6</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2016-03, Vol.293 (3), p.517-527 |
| issn | 0932-0067 1432-0711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1767071515 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 3' Untranslated Regions - genetics Adult Alleles Case-Control Studies Diabetes Diabetes, Gestational - blood Diabetes, Gestational - ethnology Diabetes, Gestational - genetics Endocrinology Enzyme-Linked Immunosorbent Assay Female Genotype Genotype & phenotype Gynecology Heterozygote Human Genetics Humans Lipoproteins, LDL - blood Malondialdehyde - blood Maternal Serum Screening Tests Maternal-Fetal Medicine Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Oxidation Plasma Polymorphism, Restriction Fragment Length - genetics Polymorphism, Single Nucleotide Pregnancy Scavenger Receptors, Class E - blood Scavenger Receptors, Class E - genetics Spectrophotometry Turkey |
| title | LOX-1 gene variants and maternal levels of plasma oxidized LDL and malondialdehyde in patients with gestational diabetes mellitus |
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