Annexin V homodimer protects against ischemia reperfusion–induced acute lung injury in lung transplantation

Abstract Objective We hypothesized that administration of a homodimer of recombinant annexin V, diannexin, could shield phosphatidylserine on the endothelium, and inhibit leukocyte and platelet adhesion, thereby potentially reducing ischemia reperfusion injury (IRI) in lung transplantation. This hyp...

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Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2016-03, Vol.151 (3), p.861-869
Hauptverfasser:	Hashimoto, Kohei, MD, Kim, Hyunhee, MSc, Oishi, Hisashi, MD, PhD, Chen, Manyin, MD, Iskender, Ilker, MD, Sakamoto, Jin, MD, Ohsumi, Akihiro, MD, Guan, Zehong, MSc, Hwang, David, MD, PhD, Waddell, Thomas K., MD, PhD, Cypel, Marcelo, MD, MSc, Liu, Mingyao, MD, MSc, Keshavjee, Shaf, MD, MSc
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - etiology Acute Lung Injury - metabolism Acute Lung Injury - pathology Acute Lung Injury - physiopathology Acute Lung Injury - prevention & control Animals Annexin A5 - pharmacology apoptosis Apoptosis - drug effects Cardiothoracic Surgery Cytokines - metabolism Cytoprotection diannexin Disease Models, Animal Fibrin - metabolism Inflammation Mediators - metabolism ischemia reperfusion injury Keratin-18 - metabolism Lung - blood supply Lung - drug effects Lung - metabolism Lung - pathology Lung - physiopathology Lung - surgery Lung Transplantation - adverse effects Male Peptide Fragments - metabolism primary graft dysfunction Protective Agents - pharmacology Rats, Inbred Lew Reperfusion Injury - etiology Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - physiopathology Reperfusion Injury - prevention & control
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