Cyclodextrins in pharmaceutical formulations I: structure and physicochemical properties, formation of complexes, and types of complex
•Cyclodextrins and the complexes they form are described.•Pharmaceutical uses of cyclodextrin are enumerated.•Physical chemical properties of cyclodextrins are described.•Toxicological considerations and reglatory issues are discussed.•Mechanism of complex formation and methods to determine the type...
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Veröffentlicht in: | Drug discovery today 2016-02, Vol.21 (2), p.356-362 |
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description | •Cyclodextrins and the complexes they form are described.•Pharmaceutical uses of cyclodextrin are enumerated.•Physical chemical properties of cyclodextrins are described.•Toxicological considerations and reglatory issues are discussed.•Mechanism of complex formation and methods to determine the type of complex formed are discussed.
Cyclodextrins are cyclic oligosaccharides that have been recognized as pharmaceutical adjuvants for the past 20 years. The molecular structure of these glucose derivatives, which approximates a truncated cone, bucket, or torus, generates a hydrophilic exterior surface and a nonpolar interior cavity. Cyclodextrins can interact with appropriately sized drug molecules to yield an inclusion complex. These noncovalent inclusion complexes offer a variety of advantages over the noncomplexed form of a drug. Cyclodextrins are primarily used to enhance the aqueous solubility, physical chemical stability, and bioavailability of drugs. Their other applications include preventing drug–drug interactions, converting liquid drugs into microcrystalline powders, minimizing gastrointestinal and ocular irritation, and reducing or eliminating unpleasant taste and smell. Here, we discuss the physical chemical properties of various cyclodextrins, including the effects of substitutions on these properties. Additionally, we report on the regulatory status of their use, commercial products containing cyclodextrins, toxicological considerations, and the forces involved in complex formation. We also highlight the types of complex formed and discuss the methods used to determine the types of complex present. |
doi_str_mv | 10.1016/j.drudis.2015.11.017 |
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Cyclodextrins are cyclic oligosaccharides that have been recognized as pharmaceutical adjuvants for the past 20 years. The molecular structure of these glucose derivatives, which approximates a truncated cone, bucket, or torus, generates a hydrophilic exterior surface and a nonpolar interior cavity. Cyclodextrins can interact with appropriately sized drug molecules to yield an inclusion complex. These noncovalent inclusion complexes offer a variety of advantages over the noncomplexed form of a drug. Cyclodextrins are primarily used to enhance the aqueous solubility, physical chemical stability, and bioavailability of drugs. Their other applications include preventing drug–drug interactions, converting liquid drugs into microcrystalline powders, minimizing gastrointestinal and ocular irritation, and reducing or eliminating unpleasant taste and smell. Here, we discuss the physical chemical properties of various cyclodextrins, including the effects of substitutions on these properties. Additionally, we report on the regulatory status of their use, commercial products containing cyclodextrins, toxicological considerations, and the forces involved in complex formation. We also highlight the types of complex formed and discuss the methods used to determine the types of complex present.</description><identifier>ISSN: 1359-6446</identifier><identifier>EISSN: 1878-5832</identifier><identifier>DOI: 10.1016/j.drudis.2015.11.017</identifier><identifier>PMID: 26686054</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Chemistry, Pharmaceutical ; Cyclodextrins - chemistry ; Cyclodextrins - toxicity ; Excipients - chemistry ; Excipients - toxicity ; Humans ; Molecular Structure</subject><ispartof>Drug discovery today, 2016-02, Vol.21 (2), p.356-362</ispartof><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-18003256cbac1ef3edee1138393ddf6e2d1c535b010a761a0d40030dfad145f23</citedby><cites>FETCH-LOGICAL-c428t-18003256cbac1ef3edee1138393ddf6e2d1c535b010a761a0d40030dfad145f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.drudis.2015.11.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26686054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jambhekar, Sunil S.</creatorcontrib><creatorcontrib>Breen, Philip</creatorcontrib><title>Cyclodextrins in pharmaceutical formulations I: structure and physicochemical properties, formation of complexes, and types of complex</title><title>Drug discovery today</title><addtitle>Drug Discov Today</addtitle><description>•Cyclodextrins and the complexes they form are described.•Pharmaceutical uses of cyclodextrin are enumerated.•Physical chemical properties of cyclodextrins are described.•Toxicological considerations and reglatory issues are discussed.•Mechanism of complex formation and methods to determine the type of complex formed are discussed.
Cyclodextrins are cyclic oligosaccharides that have been recognized as pharmaceutical adjuvants for the past 20 years. The molecular structure of these glucose derivatives, which approximates a truncated cone, bucket, or torus, generates a hydrophilic exterior surface and a nonpolar interior cavity. Cyclodextrins can interact with appropriately sized drug molecules to yield an inclusion complex. These noncovalent inclusion complexes offer a variety of advantages over the noncomplexed form of a drug. Cyclodextrins are primarily used to enhance the aqueous solubility, physical chemical stability, and bioavailability of drugs. Their other applications include preventing drug–drug interactions, converting liquid drugs into microcrystalline powders, minimizing gastrointestinal and ocular irritation, and reducing or eliminating unpleasant taste and smell. Here, we discuss the physical chemical properties of various cyclodextrins, including the effects of substitutions on these properties. Additionally, we report on the regulatory status of their use, commercial products containing cyclodextrins, toxicological considerations, and the forces involved in complex formation. We also highlight the types of complex formed and discuss the methods used to determine the types of complex present.</description><subject>Chemistry, Pharmaceutical</subject><subject>Cyclodextrins - chemistry</subject><subject>Cyclodextrins - toxicity</subject><subject>Excipients - chemistry</subject><subject>Excipients - toxicity</subject><subject>Humans</subject><subject>Molecular Structure</subject><issn>1359-6446</issn><issn>1878-5832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1P7CAUhonR-P0PjOnSha2cUmjHxU3MxK_ExI2uCQOnkUlbeoHeOH_A3y0z4zWuXEEOz8M58BJyBrQACuJqWRg_GRuKkgIvAAoK9Q45hKZuct6wcjftGZ_loqrEATkKYUkplDMu9slBKUQjKK8Oycd8pTtn8D16O4TMDtn4pnyvNE7RatVlrfP91KloXTp-vM5C9JOOk8dMDSbBq2C102_Yb-jRuxF9tBguN-bGy1ybadePHb6v62svrkYMP-onZK9VXcDTr_WYvN7dvswf8qfn-8f5zVOuq7KJOTSUspILvVAasGVoEAFYw2bMmFZgaUBzxhcUqKoFKGqqJFDTKgMVb0t2TC6296ZB_04Youxt0Nh1akA3BQm1qKloKqAJrbao9i4Ej60cve2VX0mgcp2AXMptAnKdgASQKYGknX91mBY9mm_p_5cn4M8WwPTOfxa9DNrioNFYjzpK4-zvHT4B5FSc1Q</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Jambhekar, Sunil S.</creator><creator>Breen, Philip</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160201</creationdate><title>Cyclodextrins in pharmaceutical formulations I: structure and physicochemical properties, formation of complexes, and types of complex</title><author>Jambhekar, Sunil S. ; Breen, Philip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-18003256cbac1ef3edee1138393ddf6e2d1c535b010a761a0d40030dfad145f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Chemistry, Pharmaceutical</topic><topic>Cyclodextrins - chemistry</topic><topic>Cyclodextrins - toxicity</topic><topic>Excipients - chemistry</topic><topic>Excipients - toxicity</topic><topic>Humans</topic><topic>Molecular Structure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jambhekar, Sunil S.</creatorcontrib><creatorcontrib>Breen, Philip</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug discovery today</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jambhekar, Sunil S.</au><au>Breen, Philip</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclodextrins in pharmaceutical formulations I: structure and physicochemical properties, formation of complexes, and types of complex</atitle><jtitle>Drug discovery today</jtitle><addtitle>Drug Discov Today</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>21</volume><issue>2</issue><spage>356</spage><epage>362</epage><pages>356-362</pages><issn>1359-6446</issn><eissn>1878-5832</eissn><abstract>•Cyclodextrins and the complexes they form are described.•Pharmaceutical uses of cyclodextrin are enumerated.•Physical chemical properties of cyclodextrins are described.•Toxicological considerations and reglatory issues are discussed.•Mechanism of complex formation and methods to determine the type of complex formed are discussed.
Cyclodextrins are cyclic oligosaccharides that have been recognized as pharmaceutical adjuvants for the past 20 years. The molecular structure of these glucose derivatives, which approximates a truncated cone, bucket, or torus, generates a hydrophilic exterior surface and a nonpolar interior cavity. Cyclodextrins can interact with appropriately sized drug molecules to yield an inclusion complex. These noncovalent inclusion complexes offer a variety of advantages over the noncomplexed form of a drug. Cyclodextrins are primarily used to enhance the aqueous solubility, physical chemical stability, and bioavailability of drugs. Their other applications include preventing drug–drug interactions, converting liquid drugs into microcrystalline powders, minimizing gastrointestinal and ocular irritation, and reducing or eliminating unpleasant taste and smell. Here, we discuss the physical chemical properties of various cyclodextrins, including the effects of substitutions on these properties. Additionally, we report on the regulatory status of their use, commercial products containing cyclodextrins, toxicological considerations, and the forces involved in complex formation. We also highlight the types of complex formed and discuss the methods used to determine the types of complex present.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26686054</pmid><doi>10.1016/j.drudis.2015.11.017</doi><tpages>7</tpages></addata></record> |
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subjects | Chemistry, Pharmaceutical Cyclodextrins - chemistry Cyclodextrins - toxicity Excipients - chemistry Excipients - toxicity Humans Molecular Structure |
title | Cyclodextrins in pharmaceutical formulations I: structure and physicochemical properties, formation of complexes, and types of complex |
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