Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damage

Recent studies have shown that many types of cancer cells have increased levels of reactive oxygen species (ROS) and enhance antioxidant capacity as an adaptation to intrinsic oxidative stress, suggesting that cancer cells are more vulnerable to oxidative insults and are more dependent on antioxidan...

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Veröffentlicht in:Free radical biology & medicine 2016-02, Vol.91, p.264-274
Hauptverfasser: Kim, Hojin, Lee, Gong-Rak, Kim, Jiwon, Baek, Jin Young, Jo, You-Jin, Hong, Seong-Eun, Kim, Sung Hoon, Lee, Jiae, Lee, Hye In, Park, Song-Kyu, Kim, Hwan Mook, Lee, Hwa Jeong, Chang, Tong-Shin, Rhee, Sue Goo, Lee, Ju-Seog, Jeong, Woojin
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Sprache:eng
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