Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing
Foxp3-expressing regulatory T cells (Tregs) reside in tissues where they control inflammation and mediate tissue-specific functions. The skin of mice and humans contain a large number of Tregs; however, the mechanisms of how these cells function in skin remain largely unknown. In this article, we sh...
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| Veröffentlicht in: | The Journal of immunology (1950) 2016-03, Vol.196 (5), p.2010-2014 |
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| container_end_page | 2014 |
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| container_issue | 5 |
| container_start_page | 2010 |
| container_title | The Journal of immunology (1950) |
| container_volume | 196 |
| creator | Nosbaum, Audrey Prevel, Nicolas Truong, Hong-An Mehta, Pooja Ettinger, Monika Scharschmidt, Tiffany C Ali, Niwa H Pauli, Mariela L Abbas, Abul K Rosenblum, Michael D |
| description | Foxp3-expressing regulatory T cells (Tregs) reside in tissues where they control inflammation and mediate tissue-specific functions. The skin of mice and humans contain a large number of Tregs; however, the mechanisms of how these cells function in skin remain largely unknown. In this article, we show that Tregs facilitate cutaneous wound healing. Highly activated Tregs accumulated in skin early after wounding, and specific ablation of these cells resulted in delayed wound re-epithelialization and kinetics of wound closure. Tregs in wounded skin attenuated IFN-γ production and proinflammatory macrophage accumulation. Upon wounding, Tregs induce expression of the epidermal growth factor receptor (EGFR). Lineage-specific deletion of EGFR in Tregs resulted in reduced Treg accumulation and activation in wounded skin, delayed wound closure, and increased proinflammatory macrophage accumulation. Taken together, our results reveal a novel role for Tregs in facilitating skin wound repair and suggest that they use the EGFR pathway to mediate these effects. |
| doi_str_mv | 10.4049/jimmunol.1502139 |
| format | Article |
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| subjects | Animals Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Receptor, Epidermal Growth Factor - immunology T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - immunology Wound Healing - immunology |
| title | Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing |
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