Correlations between MTP and ROS Levels of Peripheral Blood Lymphocytes and Readmission in Patients with Chronic Heart Failure
Background Peripheral blood lymphocytes exhibit changes that parallel those in failing cardiomyocytes. We hypothesised that mitochondrial transmembrane potential (MTP) and reactive oxygen species (ROS) levels of lymphocytes are associated with serum NT-proBNP and short-term prognosis in patients wit...
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| creator | Song, Bingxue, MS Li, Tao, MD Chen, Shuping, MS Yang, Dandan, MS Luo, Ling, MS Wang, Tingzhong, PhD Han, Xiu, MD Bai, Ling, MD, PhD Ma, Aiqun, MD, PhD |
| description | Background Peripheral blood lymphocytes exhibit changes that parallel those in failing cardiomyocytes. We hypothesised that mitochondrial transmembrane potential (MTP) and reactive oxygen species (ROS) levels of lymphocytes are associated with serum NT-proBNP and short-term prognosis in patients with chronic heart failure (CHF). Methods Fifty-four CHF patients and 30 controls were enrolled in this prospective study. Mitochondrial transmembrane potential and ROS levels of lymphocytes were evaluated by flow cytometry and reported as the JC-1 fluorescence ratio and DCF fluorescence intensity, respectively. Serum NT-proBNP levels and biochemical parameters were also examined. All the participants received follow-up to evaluate clinical end-points after eight months. Results Chronic heart failure patients had higher levels of DCF fluorescence intensity of lymphocytes and serum NT-proBNP, as well as lower levels of JC-1 fluorescence ratios compared with those of controls (all P |
| doi_str_mv | 10.1016/j.hlc.2015.09.004 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1767067561</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1443950615013943</els_id><sourcerecordid>1767067561</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-454f2cf3c085ffe8e0ff81b84aaa673c490b63f79b3e37edb36218a9a3a205873</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhiMEoqXwA7ggH7kk-Cu2IyQkWFGKtKgrWs6W44wVL954sZNWe-G342ULBw6cZg7v-2j0TFW9JLghmIg322YMtqGYtA3uGoz5o-qccM5rqjr6-PfO6q7F4qx6lvMWYyI5655WZ1QIRhSV59XPVUwJgpl9nDLqYb4HmNCX2w0y04C-Xt-gNdxByCg6tIHk9yMkE9CHEOOA1ofdfoz2MEM-xcEMO59zYSE_oU2hwjRndO_nEa3GFCdv0RWYNKNL48OS4Hn1xJmQ4cXDvKi-XX68XV3V6-tPn1fv17XlUs01b7mj1jGLVescKMDOKdIrbowRklne4V4wJ7ueAZMw9ExQokxnmKG4VZJdVK9P3H2KPxbIsy53WgjBTBCXrIkUEgvZClKi5BS1KeacwOl98juTDppgfdSut7po10ftGne6aC-dVw_4pd_B8Lfxx3MJvD0Fikq485B0tsWNhcEnsLMeov8v_t0_bRt8cWnCdzhA3sYlTcWeJjpTjfXN8e_Ht5MWE9Zxxn4BRHeoiA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1767067561</pqid></control><display><type>article</type><title>Correlations between MTP and ROS Levels of Peripheral Blood Lymphocytes and Readmission in Patients with Chronic Heart Failure</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Song, Bingxue, MS ; Li, Tao, MD ; Chen, Shuping, MS ; Yang, Dandan, MS ; Luo, Ling, MS ; Wang, Tingzhong, PhD ; Han, Xiu, MD ; Bai, Ling, MD, PhD ; Ma, Aiqun, MD, PhD</creator><creatorcontrib>Song, Bingxue, MS ; Li, Tao, MD ; Chen, Shuping, MS ; Yang, Dandan, MS ; Luo, Ling, MS ; Wang, Tingzhong, PhD ; Han, Xiu, MD ; Bai, Ling, MD, PhD ; Ma, Aiqun, MD, PhD</creatorcontrib><description>Background Peripheral blood lymphocytes exhibit changes that parallel those in failing cardiomyocytes. We hypothesised that mitochondrial transmembrane potential (MTP) and reactive oxygen species (ROS) levels of lymphocytes are associated with serum NT-proBNP and short-term prognosis in patients with chronic heart failure (CHF). Methods Fifty-four CHF patients and 30 controls were enrolled in this prospective study. Mitochondrial transmembrane potential and ROS levels of lymphocytes were evaluated by flow cytometry and reported as the JC-1 fluorescence ratio and DCF fluorescence intensity, respectively. Serum NT-proBNP levels and biochemical parameters were also examined. All the participants received follow-up to evaluate clinical end-points after eight months. Results Chronic heart failure patients had higher levels of DCF fluorescence intensity of lymphocytes and serum NT-proBNP, as well as lower levels of JC-1 fluorescence ratios compared with those of controls (all P<0.05). A closer relationship was found between Lg(DCF fluorescence intensity of lymphocytes) or JC-1 fluorescence ratio of lymphocytes and Lg(NT-proBNP) (both P <0.05) in CHF patients. During the eight-month follow-up period, 14 CHF patients (25.9%) were readmitted for severe HF, but none died. A logistic regression analysis showed that both ROS level and MTP of the lymphocytes were independent predictors (B=7.03, P =0.006; B= - 0.32, P =0.029, respectively) of readmission of CHF patients. Conclusions In CHF patients at low risk, MTP and ROS levels of the lymphocytes showed a significant change that is associated with serum NT-proBNP and patient readmission.</description><identifier>ISSN: 1443-9506</identifier><identifier>EISSN: 1444-2892</identifier><identifier>DOI: 10.1016/j.hlc.2015.09.004</identifier><identifier>PMID: 26631827</identifier><language>eng</language><publisher>Australia: Elsevier B.V</publisher><subject>Aged ; Cardiovascular ; Chronic Disease ; Chronic heart failure ; Female ; Heart Failure - blood ; Humans ; Lymphocytes - metabolism ; Lymphocytes - pathology ; Male ; Membrane Potential, Mitochondrial ; Middle Aged ; Mitochondrial transmembrane potential ; N-terminal-probrain natriuretic peptide ; Patient Readmission ; Predictive Value of Tests ; Prospective Studies ; Reactive oxygen species ; Reactive Oxygen Species - blood ; Readmission</subject><ispartof>Heart, lung & circulation, 2016-03, Vol.25 (3), p.296-302</ispartof><rights>Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ)</rights><rights>2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ)</rights><rights>Copyright © 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-454f2cf3c085ffe8e0ff81b84aaa673c490b63f79b3e37edb36218a9a3a205873</citedby><cites>FETCH-LOGICAL-c478t-454f2cf3c085ffe8e0ff81b84aaa673c490b63f79b3e37edb36218a9a3a205873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.hlc.2015.09.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26631827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Bingxue, MS</creatorcontrib><creatorcontrib>Li, Tao, MD</creatorcontrib><creatorcontrib>Chen, Shuping, MS</creatorcontrib><creatorcontrib>Yang, Dandan, MS</creatorcontrib><creatorcontrib>Luo, Ling, MS</creatorcontrib><creatorcontrib>Wang, Tingzhong, PhD</creatorcontrib><creatorcontrib>Han, Xiu, MD</creatorcontrib><creatorcontrib>Bai, Ling, MD, PhD</creatorcontrib><creatorcontrib>Ma, Aiqun, MD, PhD</creatorcontrib><title>Correlations between MTP and ROS Levels of Peripheral Blood Lymphocytes and Readmission in Patients with Chronic Heart Failure</title><title>Heart, lung & circulation</title><addtitle>Heart Lung Circ</addtitle><description>Background Peripheral blood lymphocytes exhibit changes that parallel those in failing cardiomyocytes. We hypothesised that mitochondrial transmembrane potential (MTP) and reactive oxygen species (ROS) levels of lymphocytes are associated with serum NT-proBNP and short-term prognosis in patients with chronic heart failure (CHF). Methods Fifty-four CHF patients and 30 controls were enrolled in this prospective study. Mitochondrial transmembrane potential and ROS levels of lymphocytes were evaluated by flow cytometry and reported as the JC-1 fluorescence ratio and DCF fluorescence intensity, respectively. Serum NT-proBNP levels and biochemical parameters were also examined. All the participants received follow-up to evaluate clinical end-points after eight months. Results Chronic heart failure patients had higher levels of DCF fluorescence intensity of lymphocytes and serum NT-proBNP, as well as lower levels of JC-1 fluorescence ratios compared with those of controls (all P<0.05). A closer relationship was found between Lg(DCF fluorescence intensity of lymphocytes) or JC-1 fluorescence ratio of lymphocytes and Lg(NT-proBNP) (both P <0.05) in CHF patients. During the eight-month follow-up period, 14 CHF patients (25.9%) were readmitted for severe HF, but none died. A logistic regression analysis showed that both ROS level and MTP of the lymphocytes were independent predictors (B=7.03, P =0.006; B= - 0.32, P =0.029, respectively) of readmission of CHF patients. Conclusions In CHF patients at low risk, MTP and ROS levels of the lymphocytes showed a significant change that is associated with serum NT-proBNP and patient readmission.</description><subject>Aged</subject><subject>Cardiovascular</subject><subject>Chronic Disease</subject><subject>Chronic heart failure</subject><subject>Female</subject><subject>Heart Failure - blood</subject><subject>Humans</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Membrane Potential, Mitochondrial</subject><subject>Middle Aged</subject><subject>Mitochondrial transmembrane potential</subject><subject>N-terminal-probrain natriuretic peptide</subject><subject>Patient Readmission</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - blood</subject><subject>Readmission</subject><issn>1443-9506</issn><issn>1444-2892</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhiMEoqXwA7ggH7kk-Cu2IyQkWFGKtKgrWs6W44wVL954sZNWe-G342ULBw6cZg7v-2j0TFW9JLghmIg322YMtqGYtA3uGoz5o-qccM5rqjr6-PfO6q7F4qx6lvMWYyI5655WZ1QIRhSV59XPVUwJgpl9nDLqYb4HmNCX2w0y04C-Xt-gNdxByCg6tIHk9yMkE9CHEOOA1ofdfoz2MEM-xcEMO59zYSE_oU2hwjRndO_nEa3GFCdv0RWYNKNL48OS4Hn1xJmQ4cXDvKi-XX68XV3V6-tPn1fv17XlUs01b7mj1jGLVescKMDOKdIrbowRklne4V4wJ7ueAZMw9ExQokxnmKG4VZJdVK9P3H2KPxbIsy53WgjBTBCXrIkUEgvZClKi5BS1KeacwOl98juTDppgfdSut7po10ftGne6aC-dVw_4pd_B8Lfxx3MJvD0Fikq485B0tsWNhcEnsLMeov8v_t0_bRt8cWnCdzhA3sYlTcWeJjpTjfXN8e_Ht5MWE9Zxxn4BRHeoiA</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Song, Bingxue, MS</creator><creator>Li, Tao, MD</creator><creator>Chen, Shuping, MS</creator><creator>Yang, Dandan, MS</creator><creator>Luo, Ling, MS</creator><creator>Wang, Tingzhong, PhD</creator><creator>Han, Xiu, MD</creator><creator>Bai, Ling, MD, PhD</creator><creator>Ma, Aiqun, MD, PhD</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160301</creationdate><title>Correlations between MTP and ROS Levels of Peripheral Blood Lymphocytes and Readmission in Patients with Chronic Heart Failure</title><author>Song, Bingxue, MS ; Li, Tao, MD ; Chen, Shuping, MS ; Yang, Dandan, MS ; Luo, Ling, MS ; Wang, Tingzhong, PhD ; Han, Xiu, MD ; Bai, Ling, MD, PhD ; Ma, Aiqun, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-454f2cf3c085ffe8e0ff81b84aaa673c490b63f79b3e37edb36218a9a3a205873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Cardiovascular</topic><topic>Chronic Disease</topic><topic>Chronic heart failure</topic><topic>Female</topic><topic>Heart Failure - blood</topic><topic>Humans</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Membrane Potential, Mitochondrial</topic><topic>Middle Aged</topic><topic>Mitochondrial transmembrane potential</topic><topic>N-terminal-probrain natriuretic peptide</topic><topic>Patient Readmission</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - blood</topic><topic>Readmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Bingxue, MS</creatorcontrib><creatorcontrib>Li, Tao, MD</creatorcontrib><creatorcontrib>Chen, Shuping, MS</creatorcontrib><creatorcontrib>Yang, Dandan, MS</creatorcontrib><creatorcontrib>Luo, Ling, MS</creatorcontrib><creatorcontrib>Wang, Tingzhong, PhD</creatorcontrib><creatorcontrib>Han, Xiu, MD</creatorcontrib><creatorcontrib>Bai, Ling, MD, PhD</creatorcontrib><creatorcontrib>Ma, Aiqun, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Heart, lung & circulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Bingxue, MS</au><au>Li, Tao, MD</au><au>Chen, Shuping, MS</au><au>Yang, Dandan, MS</au><au>Luo, Ling, MS</au><au>Wang, Tingzhong, PhD</au><au>Han, Xiu, MD</au><au>Bai, Ling, MD, PhD</au><au>Ma, Aiqun, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlations between MTP and ROS Levels of Peripheral Blood Lymphocytes and Readmission in Patients with Chronic Heart Failure</atitle><jtitle>Heart, lung & circulation</jtitle><addtitle>Heart Lung Circ</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>25</volume><issue>3</issue><spage>296</spage><epage>302</epage><pages>296-302</pages><issn>1443-9506</issn><eissn>1444-2892</eissn><abstract>Background Peripheral blood lymphocytes exhibit changes that parallel those in failing cardiomyocytes. We hypothesised that mitochondrial transmembrane potential (MTP) and reactive oxygen species (ROS) levels of lymphocytes are associated with serum NT-proBNP and short-term prognosis in patients with chronic heart failure (CHF). Methods Fifty-four CHF patients and 30 controls were enrolled in this prospective study. Mitochondrial transmembrane potential and ROS levels of lymphocytes were evaluated by flow cytometry and reported as the JC-1 fluorescence ratio and DCF fluorescence intensity, respectively. Serum NT-proBNP levels and biochemical parameters were also examined. All the participants received follow-up to evaluate clinical end-points after eight months. Results Chronic heart failure patients had higher levels of DCF fluorescence intensity of lymphocytes and serum NT-proBNP, as well as lower levels of JC-1 fluorescence ratios compared with those of controls (all P<0.05). A closer relationship was found between Lg(DCF fluorescence intensity of lymphocytes) or JC-1 fluorescence ratio of lymphocytes and Lg(NT-proBNP) (both P <0.05) in CHF patients. During the eight-month follow-up period, 14 CHF patients (25.9%) were readmitted for severe HF, but none died. A logistic regression analysis showed that both ROS level and MTP of the lymphocytes were independent predictors (B=7.03, P =0.006; B= - 0.32, P =0.029, respectively) of readmission of CHF patients. Conclusions In CHF patients at low risk, MTP and ROS levels of the lymphocytes showed a significant change that is associated with serum NT-proBNP and patient readmission.</abstract><cop>Australia</cop><pub>Elsevier B.V</pub><pmid>26631827</pmid><doi>10.1016/j.hlc.2015.09.004</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Cardiovascular Chronic Disease Chronic heart failure Female Heart Failure - blood Humans Lymphocytes - metabolism Lymphocytes - pathology Male Membrane Potential, Mitochondrial Middle Aged Mitochondrial transmembrane potential N-terminal-probrain natriuretic peptide Patient Readmission Predictive Value of Tests Prospective Studies Reactive oxygen species Reactive Oxygen Species - blood Readmission |
| title | Correlations between MTP and ROS Levels of Peripheral Blood Lymphocytes and Readmission in Patients with Chronic Heart Failure |
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