Dopamine, depressive symptoms, and decision-making: the relationship between spontaneous eye blink rate and depressive symptoms predicts Iowa Gambling Task performance
Depressive symptomatology has been associated with alterations in decision-making, although conclusions have been mixed, with depressed individuals showing impairments in some contexts but advantages in others. The dopaminergic system may link depressive symptoms with decision-making performance. We...
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| Veröffentlicht in: | Cognitive, affective, & behavioral neuroscience affective, & behavioral neuroscience, 2016-02, Vol.16 (1), p.23-36 |
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| creator | Byrne, Kaileigh A. Norris, Dominique D. Worthy, Darrell A. |
| description | Depressive symptomatology has been associated with alterations in decision-making, although conclusions have been mixed, with depressed individuals showing impairments in some contexts but advantages in others. The dopaminergic system may link depressive symptoms with decision-making performance. We assessed the role of striatal dopamine D
2
receptor density, using spontaneous eye blink rates, in moderating the relationship between depressive symptoms and decision-making performance in a large undergraduate sample that had not been screened for mental illness (
N
= 104). The regression results revealed that eye blink rate moderated the relationship between depressive symptoms and advantageous decisions on the Iowa Gambling Task, in which individuals with more depressive symptomatology and high blink rates (higher striatal dopamine D
2
receptor density) performed better on the task. Our computational modeling results demonstrated that depressive symptoms alone were associated with enhanced loss-aversive behavior, whereas individuals with high blink rates and elevated depressive symptoms tended to persevere in selecting options that led to net gains (avoiding options with net losses). These findings suggest that variation in striatal dopamine D
2
receptor availability in individuals with depressive symptoms may contribute to differences in decision-making behavior. |
| doi_str_mv | 10.3758/s13415-015-0377-0 |
| format | Article |
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2
receptor density, using spontaneous eye blink rates, in moderating the relationship between depressive symptoms and decision-making performance in a large undergraduate sample that had not been screened for mental illness (
N
= 104). The regression results revealed that eye blink rate moderated the relationship between depressive symptoms and advantageous decisions on the Iowa Gambling Task, in which individuals with more depressive symptomatology and high blink rates (higher striatal dopamine D
2
receptor density) performed better on the task. Our computational modeling results demonstrated that depressive symptoms alone were associated with enhanced loss-aversive behavior, whereas individuals with high blink rates and elevated depressive symptoms tended to persevere in selecting options that led to net gains (avoiding options with net losses). These findings suggest that variation in striatal dopamine D
2
receptor availability in individuals with depressive symptoms may contribute to differences in decision-making behavior.</description><identifier>ISSN: 1530-7026</identifier><identifier>EISSN: 1531-135X</identifier><identifier>DOI: 10.3758/s13415-015-0377-0</identifier><identifier>PMID: 26383904</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescent ; Behavioral Science and Psychology ; Blinking - physiology ; Cognitive Psychology ; Corpus Striatum - physiology ; Decision Making - physiology ; Depression - psychology ; Dopamine - metabolism ; Eye ; Female ; Gambling - psychology ; Humans ; Male ; Neuropsychological Tests ; Neurosciences ; Psychology ; Task Performance and Analysis ; Young Adult</subject><ispartof>Cognitive, affective, & behavioral neuroscience, 2016-02, Vol.16 (1), p.23-36</ispartof><rights>Psychonomic Society, Inc. 2015</rights><rights>Copyright Springer Science & Business Media Feb 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-f774c212f4611dd28c26ac67c06a031fb48a4703e13d64d7c1f76ce19b3e3b123</citedby><cites>FETCH-LOGICAL-c485t-f774c212f4611dd28c26ac67c06a031fb48a4703e13d64d7c1f76ce19b3e3b123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.3758/s13415-015-0377-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.3758/s13415-015-0377-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26383904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Byrne, Kaileigh A.</creatorcontrib><creatorcontrib>Norris, Dominique D.</creatorcontrib><creatorcontrib>Worthy, Darrell A.</creatorcontrib><title>Dopamine, depressive symptoms, and decision-making: the relationship between spontaneous eye blink rate and depressive symptoms predicts Iowa Gambling Task performance</title><title>Cognitive, affective, & behavioral neuroscience</title><addtitle>Cogn Affect Behav Neurosci</addtitle><addtitle>Cogn Affect Behav Neurosci</addtitle><description>Depressive symptomatology has been associated with alterations in decision-making, although conclusions have been mixed, with depressed individuals showing impairments in some contexts but advantages in others. The dopaminergic system may link depressive symptoms with decision-making performance. We assessed the role of striatal dopamine D
2
receptor density, using spontaneous eye blink rates, in moderating the relationship between depressive symptoms and decision-making performance in a large undergraduate sample that had not been screened for mental illness (
N
= 104). The regression results revealed that eye blink rate moderated the relationship between depressive symptoms and advantageous decisions on the Iowa Gambling Task, in which individuals with more depressive symptomatology and high blink rates (higher striatal dopamine D
2
receptor density) performed better on the task. Our computational modeling results demonstrated that depressive symptoms alone were associated with enhanced loss-aversive behavior, whereas individuals with high blink rates and elevated depressive symptoms tended to persevere in selecting options that led to net gains (avoiding options with net losses). These findings suggest that variation in striatal dopamine D
2
receptor availability in individuals with depressive symptoms may contribute to differences in decision-making behavior.</description><subject>Adolescent</subject><subject>Behavioral Science and Psychology</subject><subject>Blinking - physiology</subject><subject>Cognitive Psychology</subject><subject>Corpus Striatum - physiology</subject><subject>Decision Making - physiology</subject><subject>Depression - psychology</subject><subject>Dopamine - metabolism</subject><subject>Eye</subject><subject>Female</subject><subject>Gambling - psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Neuropsychological Tests</subject><subject>Neurosciences</subject><subject>Psychology</subject><subject>Task Performance and Analysis</subject><subject>Young Adult</subject><issn>1530-7026</issn><issn>1531-135X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc9u1DAQxi0EomXhAbggS1w4NOB_sbPcqgKlUiUuReIWOc5k625sB0-Wap-I18RLFoRAHMYezfzmG1sfIc85ey1N3bxBLhWvK3YIaUzFHpBTXktecVl_efgzZ5VhQp-QJ4h3jDEllHhMToSWjVwzdUq-v0uTDT7CGe1hyoDovwHFfZjmFPCM2tiXhvPoU6yC3fq4eUvnW6AZRjuXIt76iXYw3wNEilOKs42QdkhhD7QbfdzSbGc4Cv2zgZZK792M9CrdW3ppw2FmQ28sbukEeUg52OjgKXk02BHh2fFekc8f3t9cfKyuP11eXZxfV0419VwNxignuBiU5rzvReOEtk4bx7Rlkg-daqwyTAKXvVa9cXww2gFfdxJkx4VckVeL7pTT1x3g3AaPDsZx-VXLjTZMG6nWBX35F3qXdjmW1xXKKCnqNasLxRfK5YSYYWin7IPN-5az9uBiu7jYskMUF8uxIi-OyrsuQP974pdtBRALgKUVN5D_WP1f1R--GqsQ</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Byrne, Kaileigh A.</creator><creator>Norris, Dominique D.</creator><creator>Worthy, Darrell A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160201</creationdate><title>Dopamine, depressive symptoms, and decision-making: the relationship between spontaneous eye blink rate and depressive symptoms predicts Iowa Gambling Task performance</title><author>Byrne, Kaileigh A. ; 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The dopaminergic system may link depressive symptoms with decision-making performance. We assessed the role of striatal dopamine D
2
receptor density, using spontaneous eye blink rates, in moderating the relationship between depressive symptoms and decision-making performance in a large undergraduate sample that had not been screened for mental illness (
N
= 104). The regression results revealed that eye blink rate moderated the relationship between depressive symptoms and advantageous decisions on the Iowa Gambling Task, in which individuals with more depressive symptomatology and high blink rates (higher striatal dopamine D
2
receptor density) performed better on the task. Our computational modeling results demonstrated that depressive symptoms alone were associated with enhanced loss-aversive behavior, whereas individuals with high blink rates and elevated depressive symptoms tended to persevere in selecting options that led to net gains (avoiding options with net losses). These findings suggest that variation in striatal dopamine D
2
receptor availability in individuals with depressive symptoms may contribute to differences in decision-making behavior.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26383904</pmid><doi>10.3758/s13415-015-0377-0</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Behavioral Science and Psychology Blinking - physiology Cognitive Psychology Corpus Striatum - physiology Decision Making - physiology Depression - psychology Dopamine - metabolism Eye Female Gambling - psychology Humans Male Neuropsychological Tests Neurosciences Psychology Task Performance and Analysis Young Adult |
| title | Dopamine, depressive symptoms, and decision-making: the relationship between spontaneous eye blink rate and depressive symptoms predicts Iowa Gambling Task performance |
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