HB-EGF-Promoted Airway Smooth Muscle Cells and Their Progenitor Migration Contribute to Airway Smooth Muscle Remodeling in Asthmatic Mouse

The airway smooth muscle (ASM) cells' proliferation, migration, and their progenitor's migration are currently regarded as causative factors for ASM remodeling in asthma. Heparin-binding epidermal growth factor (HB-EGF), a potent mitogen and chemotactic factor, could promote ASM cell proli...

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Veröffentlicht in:	The Journal of immunology (1950) 2016-03, Vol.196 (5), p.2361-2367
Hauptverfasser:	Wang, Qing, Li, Hequan, Yao, Yinan, Lu, Guohua, Wang, Yuehong, Xia, Dajing, Zhou, Jianying
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Actins - metabolism Airway Remodeling - drug effects Animals Asthma - metabolism Asthma - pathology Biomarkers Cell Differentiation Cell Movement - drug effects Gene Expression Heparin-binding EGF-like Growth Factor - metabolism Heparin-binding EGF-like Growth Factor - pharmacology Male MAP Kinase Signaling System - drug effects Mice Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Myofibroblasts - cytology Myofibroblasts - drug effects Myofibroblasts - metabolism p38 Mitogen-Activated Protein Kinases - metabolism
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