Tumor Necrosis Factor (TNF) α Increases Collagen Accumulation and Proliferation in Intestinal Myofibroblasts via TNF Receptor 2

Intestinal fibrosis is an incurable complication of Crohn's disease involving increased numbers of collagen-producing myofibroblasts. Tumor necrosis factor (TNF) α has defined proinflammatory roles in Crohn's disease but its role in fibrosis is unclear. We tested the hypothesis that TNFα i...

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Veröffentlicht in:	The Journal of biological chemistry 2005-10, Vol.280 (43), p.36099-36109
Hauptverfasser:	Theiss, Arianne L., Simmons, James G., Jobin, Christian, Lund, P. Kay
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Northern Blotting, Western Cell Proliferation Collagen - metabolism DNA - chemistry DNA - metabolism Dose-Response Relationship, Drug Enzyme Activation Fibroblasts - metabolism Fibrosis - metabolism Genotype Green Fluorescent Proteins - metabolism Homozygote Inflammation Insulin-Like Growth Factor I - metabolism Intestinal Mucosa - metabolism Matrix Metalloproteinase 2 - metabolism Mice Mice, Transgenic Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism NF-kappa B - metabolism Protein Isoforms Receptors, Tumor Necrosis Factor - chemistry Receptors, Tumor Necrosis Factor, Type II - metabolism RNA - metabolism RNA, Messenger - metabolism Signal Transduction STAT3 Transcription Factor - metabolism STAT3 Transcription Factor - physiology Time Factors Tissue Inhibitor of Metalloproteinase-1 - metabolism Transcription Factor AP-1 - metabolism Transcription, Genetic Transcriptional Activation Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - physiology Up-Regulation
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