Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface
This study aims at improving osseo-integration at the bone-implant interface of polyetheretherketone (PEEK) by water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII). The pertinent surface characteristics including surface energy, roughness, morphology, and chemical composition are i...
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| Veröffentlicht in: | ACS applied materials & interfaces 2016-02, Vol.8 (6), p.3901-3911 |
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| creator | Zhao, Ying Wong, Hoi Man Lui, So Ching Chong, Eva Y. W Wu, Guosong Zhao, Xiaoli Wang, Chong Pan, Haobo Cheung, Kenneth M. C Wu, Shuilin Chu, Paul K Yeung, Kelvin W. K |
| description | This study aims at improving osseo-integration at the bone-implant interface of polyetheretherketone (PEEK) by water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII). The pertinent surface characteristics including surface energy, roughness, morphology, and chemical composition are investigated systematically and the in vitro biological performance is evaluated by cell adhesion and proliferation, alkaline phosphatase (ALP) activity, real-time RT-PCR evaluation, and mineralization tests. In vivo osseo-integration is examined via implanting samples into the distal femur of the rats. The hydrophilicity, surface roughness, cell adhesion, and proliferation, ALP activity, and osteogenic differentiation after H2O PIII or NH3 PIII are improved significantly. Furthermore, substantially enhanced osseo-integration is achieved in vivo. Nonline-of-sight plasma surface functionalization, which is particularly suitable for biomedical implants with an irregular geometry, does not alter the bulk compressive yield strength and elastic modulus of the materials. Consequently, the favorable bulk attributes of PEEK are preserved while the surface biological properties are enhanced thus boding well for wider orthopedic application of the biopolymer. |
| doi_str_mv | 10.1021/acsami.5b10881 |
| format | Article |
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W ; Wu, Guosong ; Zhao, Xiaoli ; Wang, Chong ; Pan, Haobo ; Cheung, Kenneth M. C ; Wu, Shuilin ; Chu, Paul K ; Yeung, Kelvin W. K</creator><creatorcontrib>Zhao, Ying ; Wong, Hoi Man ; Lui, So Ching ; Chong, Eva Y. W ; Wu, Guosong ; Zhao, Xiaoli ; Wang, Chong ; Pan, Haobo ; Cheung, Kenneth M. C ; Wu, Shuilin ; Chu, Paul K ; Yeung, Kelvin W. K</creatorcontrib><description>This study aims at improving osseo-integration at the bone-implant interface of polyetheretherketone (PEEK) by water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII). The pertinent surface characteristics including surface energy, roughness, morphology, and chemical composition are investigated systematically and the in vitro biological performance is evaluated by cell adhesion and proliferation, alkaline phosphatase (ALP) activity, real-time RT-PCR evaluation, and mineralization tests. In vivo osseo-integration is examined via implanting samples into the distal femur of the rats. The hydrophilicity, surface roughness, cell adhesion, and proliferation, ALP activity, and osteogenic differentiation after H2O PIII or NH3 PIII are improved significantly. Furthermore, substantially enhanced osseo-integration is achieved in vivo. Nonline-of-sight plasma surface functionalization, which is particularly suitable for biomedical implants with an irregular geometry, does not alter the bulk compressive yield strength and elastic modulus of the materials. Consequently, the favorable bulk attributes of PEEK are preserved while the surface biological properties are enhanced thus boding well for wider orthopedic application of the biopolymer.</description><identifier>ISSN: 1944-8244</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.5b10881</identifier><identifier>PMID: 26796319</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Bone-Implant Interface ; Cell Line ; Female ; Implants, Experimental ; Ketones - chemistry ; Ketones - pharmacology ; Materials Testing ; Mice ; Osseointegration - drug effects ; Osteogenesis - drug effects ; Plasma Gases ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - pharmacology ; Rats ; Rats, Sprague-Dawley</subject><ispartof>ACS applied materials & interfaces, 2016-02, Vol.8 (6), p.3901-3911</ispartof><rights>Copyright © 2016 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a396t-23f8cc3fc043379a00f848a5f17fa65c4a9a01ee8d378c7e80dd0e1e29d291c73</citedby><cites>FETCH-LOGICAL-a396t-23f8cc3fc043379a00f848a5f17fa65c4a9a01ee8d378c7e80dd0e1e29d291c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsami.5b10881$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsami.5b10881$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26796319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Ying</creatorcontrib><creatorcontrib>Wong, Hoi Man</creatorcontrib><creatorcontrib>Lui, So Ching</creatorcontrib><creatorcontrib>Chong, Eva Y. 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The pertinent surface characteristics including surface energy, roughness, morphology, and chemical composition are investigated systematically and the in vitro biological performance is evaluated by cell adhesion and proliferation, alkaline phosphatase (ALP) activity, real-time RT-PCR evaluation, and mineralization tests. In vivo osseo-integration is examined via implanting samples into the distal femur of the rats. The hydrophilicity, surface roughness, cell adhesion, and proliferation, ALP activity, and osteogenic differentiation after H2O PIII or NH3 PIII are improved significantly. Furthermore, substantially enhanced osseo-integration is achieved in vivo. Nonline-of-sight plasma surface functionalization, which is particularly suitable for biomedical implants with an irregular geometry, does not alter the bulk compressive yield strength and elastic modulus of the materials. Consequently, the favorable bulk attributes of PEEK are preserved while the surface biological properties are enhanced thus boding well for wider orthopedic application of the biopolymer.</description><subject>Animals</subject><subject>Bone-Implant Interface</subject><subject>Cell Line</subject><subject>Female</subject><subject>Implants, Experimental</subject><subject>Ketones - chemistry</subject><subject>Ketones - pharmacology</subject><subject>Materials Testing</subject><subject>Mice</subject><subject>Osseointegration - drug effects</subject><subject>Osteogenesis - drug effects</subject><subject>Plasma Gases</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAURi0EolBYGVFGhJTiRx7OCFULlSq1EjBHt841TZvExU6G8utxH3Rj8bXs8326OoTcMTpglLMnUA7qchAvGJWSnZErlkVRKHnMz0_3KOqRa-dWlCaC0_iS9HiSZolg2RVZzytwNQTvndWgMBh3jWpL00BV_mARzE21xXaJdn-ssTUNBtrYYNQsoVGemDmHJpw0LX5Z2CUDaIMXj4WTelNB0wa7v335DbnQUDm8Pc4--RyPPoZv4XT2Ohk-T0MQWdKGXGiplNCKRkKkGVCqZSQh1izVkMQqAv_GEGUhUqlSlLQoKDLkWcEzplLRJw-H3o013x26Nq9Lp7Dy26DpXM7SJOFJ7Ls9OjigyhrnLOp8Y8sa7DZnNN8Jzg-C86NgH7g_dneLGosT_mfUA48HwAfzlemsV-n-a_sFlVqHhg</recordid><startdate>20160217</startdate><enddate>20160217</enddate><creator>Zhao, Ying</creator><creator>Wong, Hoi Man</creator><creator>Lui, So Ching</creator><creator>Chong, Eva Y. W</creator><creator>Wu, Guosong</creator><creator>Zhao, Xiaoli</creator><creator>Wang, Chong</creator><creator>Pan, Haobo</creator><creator>Cheung, Kenneth M. C</creator><creator>Wu, Shuilin</creator><creator>Chu, Paul K</creator><creator>Yeung, Kelvin W. K</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160217</creationdate><title>Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface</title><author>Zhao, Ying ; Wong, Hoi Man ; Lui, So Ching ; Chong, Eva Y. W ; Wu, Guosong ; Zhao, Xiaoli ; Wang, Chong ; Pan, Haobo ; Cheung, Kenneth M. C ; Wu, Shuilin ; Chu, Paul K ; Yeung, Kelvin W. 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W</au><au>Wu, Guosong</au><au>Zhao, Xiaoli</au><au>Wang, Chong</au><au>Pan, Haobo</au><au>Cheung, Kenneth M. C</au><au>Wu, Shuilin</au><au>Chu, Paul K</au><au>Yeung, Kelvin W. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2016-02-17</date><risdate>2016</risdate><volume>8</volume><issue>6</issue><spage>3901</spage><epage>3911</epage><pages>3901-3911</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>This study aims at improving osseo-integration at the bone-implant interface of polyetheretherketone (PEEK) by water (H2O) and ammonia (NH3) plasma immersion ion implantation (PIII). The pertinent surface characteristics including surface energy, roughness, morphology, and chemical composition are investigated systematically and the in vitro biological performance is evaluated by cell adhesion and proliferation, alkaline phosphatase (ALP) activity, real-time RT-PCR evaluation, and mineralization tests. In vivo osseo-integration is examined via implanting samples into the distal femur of the rats. The hydrophilicity, surface roughness, cell adhesion, and proliferation, ALP activity, and osteogenic differentiation after H2O PIII or NH3 PIII are improved significantly. Furthermore, substantially enhanced osseo-integration is achieved in vivo. Nonline-of-sight plasma surface functionalization, which is particularly suitable for biomedical implants with an irregular geometry, does not alter the bulk compressive yield strength and elastic modulus of the materials. Consequently, the favorable bulk attributes of PEEK are preserved while the surface biological properties are enhanced thus boding well for wider orthopedic application of the biopolymer.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>26796319</pmid><doi>10.1021/acsami.5b10881</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Bone-Implant Interface Cell Line Female Implants, Experimental Ketones - chemistry Ketones - pharmacology Materials Testing Mice Osseointegration - drug effects Osteogenesis - drug effects Plasma Gases Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Rats Rats, Sprague-Dawley |
| title | Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface |
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