Protective Effects of Hippophae rhamnoides L. Juice on Lead-Induced Neurotoxicity in Mice
We examined the effect of Hippophae rhamnoides L. (HRL) juice on lead-induced memory impairment and neuronal damage in the brains of adult mice. Kunming mice were exposed to lead acetate 10 mg/kg body weight for 20 d. Twenty percent and 40% HRL prevented the lead-induced decrease in step-through lat...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2005, Vol.28(3), pp.490-494 |
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| creator | Xu, Yanji Li, Guangzhe Han, Chunji Sun, Lianping Zhao, Rongjie Cui, Santian |
| description | We examined the effect of Hippophae rhamnoides L. (HRL) juice on lead-induced memory impairment and neuronal damage in the brains of adult mice. Kunming mice were exposed to lead acetate 10 mg/kg body weight for 20 d. Twenty percent and 40% HRL prevented the lead-induced decrease in step-through latency. In the water maze test, the swimming time was lengthened in mice treated with lead acetate, but this time was decreased in mice that received 20% and 40% HRL. The malondialdehyde (MDA) levels were increased in lead-treated mice, which were reduced by 20% and 40% HRL in dose-dependent manner. The activities of acetylcholinesterase (AchE) and monoamine oxidase-A and -B were significantly increased in the lead-treated group, which were decreased by 40% HRL but not by 20% HRL. The levels of norepinephrine, serotonin, and 5-hydroxyindole acetic acid were decreased significantly in the lead-treated mice, and the decreases were antagonized by 40% HRL, except for than in dopamine, but 20% HRL had no effect on this change. These data suggest that the different doses of the HRL juice protect against the lead acetate-induced deficits in learning and memory and changes in neurobiochemical parameters. |
| doi_str_mv | 10.1248/bpb.28.490 |
| format | Article |
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Juice on Lead-Induced Neurotoxicity in Mice</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Xu, Yanji ; Li, Guangzhe ; Han, Chunji ; Sun, Lianping ; Zhao, Rongjie ; Cui, Santian</creator><creatorcontrib>Xu, Yanji ; Li, Guangzhe ; Han, Chunji ; Sun, Lianping ; Zhao, Rongjie ; Cui, Santian ; Hygiene ; aDepartment of Preventive Medicine ; cDepartment of Pharmacology ; Yanbian University Medicine College ; Yanbian Brain Hospital ; bDepartment of Psychiatry</creatorcontrib><description>We examined the effect of Hippophae rhamnoides L. (HRL) juice on lead-induced memory impairment and neuronal damage in the brains of adult mice. Kunming mice were exposed to lead acetate 10 mg/kg body weight for 20 d. Twenty percent and 40% HRL prevented the lead-induced decrease in step-through latency. In the water maze test, the swimming time was lengthened in mice treated with lead acetate, but this time was decreased in mice that received 20% and 40% HRL. The malondialdehyde (MDA) levels were increased in lead-treated mice, which were reduced by 20% and 40% HRL in dose-dependent manner. The activities of acetylcholinesterase (AchE) and monoamine oxidase-A and -B were significantly increased in the lead-treated group, which were decreased by 40% HRL but not by 20% HRL. The levels of norepinephrine, serotonin, and 5-hydroxyindole acetic acid were decreased significantly in the lead-treated mice, and the decreases were antagonized by 40% HRL, except for than in dopamine, but 20% HRL had no effect on this change. These data suggest that the different doses of the HRL juice protect against the lead acetate-induced deficits in learning and memory and changes in neurobiochemical parameters.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.28.490</identifier><identifier>PMID: 15744075</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>acetylcholinesterase ; Animals ; Avoidance Learning - drug effects ; Avoidance Learning - physiology ; Brain - drug effects ; Brain - metabolism ; Female ; Fruit ; Hippophae ; Hippophae rhamnoides L ; lead ; Lead Poisoning, Nervous System - metabolism ; Lead Poisoning, Nervous System - prevention & control ; Male ; malondialdehyde ; memory deficit ; Mice ; monoamine oxidase ; Neuroprotective Agents - isolation & purification ; Neuroprotective Agents - pharmacology ; Neuroprotective Agents - therapeutic use ; neurotransmitter ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Oils - isolation & purification ; Plant Oils - pharmacology ; Plant Oils - therapeutic use</subject><ispartof>Biological and Pharmaceutical Bulletin, 2005, Vol.28(3), pp.490-494</ispartof><rights>2005 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c601t-ca59d7ba3b08c89850d061203544834c8064f1552a210875aefda9909d412de73</citedby><cites>FETCH-LOGICAL-c601t-ca59d7ba3b08c89850d061203544834c8064f1552a210875aefda9909d412de73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15744075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Yanji</creatorcontrib><creatorcontrib>Li, Guangzhe</creatorcontrib><creatorcontrib>Han, Chunji</creatorcontrib><creatorcontrib>Sun, Lianping</creatorcontrib><creatorcontrib>Zhao, Rongjie</creatorcontrib><creatorcontrib>Cui, Santian</creatorcontrib><creatorcontrib>Hygiene</creatorcontrib><creatorcontrib>aDepartment of Preventive Medicine</creatorcontrib><creatorcontrib>cDepartment of Pharmacology</creatorcontrib><creatorcontrib>Yanbian University Medicine College</creatorcontrib><creatorcontrib>Yanbian Brain Hospital</creatorcontrib><creatorcontrib>bDepartment of Psychiatry</creatorcontrib><title>Protective Effects of Hippophae rhamnoides L. Juice on Lead-Induced Neurotoxicity in Mice</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>We examined the effect of Hippophae rhamnoides L. (HRL) juice on lead-induced memory impairment and neuronal damage in the brains of adult mice. Kunming mice were exposed to lead acetate 10 mg/kg body weight for 20 d. Twenty percent and 40% HRL prevented the lead-induced decrease in step-through latency. In the water maze test, the swimming time was lengthened in mice treated with lead acetate, but this time was decreased in mice that received 20% and 40% HRL. The malondialdehyde (MDA) levels were increased in lead-treated mice, which were reduced by 20% and 40% HRL in dose-dependent manner. The activities of acetylcholinesterase (AchE) and monoamine oxidase-A and -B were significantly increased in the lead-treated group, which were decreased by 40% HRL but not by 20% HRL. The levels of norepinephrine, serotonin, and 5-hydroxyindole acetic acid were decreased significantly in the lead-treated mice, and the decreases were antagonized by 40% HRL, except for than in dopamine, but 20% HRL had no effect on this change. These data suggest that the different doses of the HRL juice protect against the lead acetate-induced deficits in learning and memory and changes in neurobiochemical parameters.</description><subject>acetylcholinesterase</subject><subject>Animals</subject><subject>Avoidance Learning - drug effects</subject><subject>Avoidance Learning - physiology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Female</subject><subject>Fruit</subject><subject>Hippophae</subject><subject>Hippophae rhamnoides L</subject><subject>lead</subject><subject>Lead Poisoning, Nervous System - metabolism</subject><subject>Lead Poisoning, Nervous System - prevention & control</subject><subject>Male</subject><subject>malondialdehyde</subject><subject>memory deficit</subject><subject>Mice</subject><subject>monoamine oxidase</subject><subject>Neuroprotective Agents - isolation & purification</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>neurotransmitter</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Oils - isolation & purification</subject><subject>Plant Oils - pharmacology</subject><subject>Plant Oils - therapeutic use</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE2LFDEQhoMo7rh68QdIQPAg9Fj56qRPIsu6uzJ-HPTgKaTT1U6Gnk5v0i3uvzfDzLrgpSpQT94qHkJeMlgzLs27dmrX3KxlA4_IigmpK8WZekxW0DBT1UyZM_Is5x0AaODiKTljSksJWq3Iz28pzujn8BvpZd-XV6axp9dhmuK0dUjT1u3HGDrMdLOmn5bgkcaRbtB11c3YLR47-gWXkhL_BB_mOxpG-rlQz8mT3g0ZX5z6Ofnx8fL7xXW1-Xp1c_FhU_ka2Fx5p5pOt060YLxpjIIOasZBKCmNkN5ALXumFHecgdHKYd-5poGmk4x3qMU5eXPMnVK8XTDPdh-yx2FwI8YlW6brmhdPBXz9H7iLSxrLbZZJ2YgipDGFenukfIo5J-ztlMLepTvLwB5026LbcmOL7gK_OkUu7R67B_TktwBXR6BMg3dDHIcw4sNin3Ub4hAtB1AWgBsQFpi2UOIPRTLQtTKiJL0_Ju3y7H7hv1UuzcEPeH-VOJbD7_uJ37pkcRR_AVR_pdw</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Xu, Yanji</creator><creator>Li, Guangzhe</creator><creator>Han, Chunji</creator><creator>Sun, Lianping</creator><creator>Zhao, Rongjie</creator><creator>Cui, Santian</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20050301</creationdate><title>Protective Effects of Hippophae rhamnoides L. Juice on Lead-Induced Neurotoxicity in Mice</title><author>Xu, Yanji ; Li, Guangzhe ; Han, Chunji ; Sun, Lianping ; Zhao, Rongjie ; Cui, Santian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c601t-ca59d7ba3b08c89850d061203544834c8064f1552a210875aefda9909d412de73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>acetylcholinesterase</topic><topic>Animals</topic><topic>Avoidance Learning - drug effects</topic><topic>Avoidance Learning - physiology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Female</topic><topic>Fruit</topic><topic>Hippophae</topic><topic>Hippophae rhamnoides L</topic><topic>lead</topic><topic>Lead Poisoning, Nervous System - metabolism</topic><topic>Lead Poisoning, Nervous System - prevention & control</topic><topic>Male</topic><topic>malondialdehyde</topic><topic>memory deficit</topic><topic>Mice</topic><topic>monoamine oxidase</topic><topic>Neuroprotective Agents - isolation & purification</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>neurotransmitter</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Oils - isolation & purification</topic><topic>Plant Oils - pharmacology</topic><topic>Plant Oils - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Yanji</creatorcontrib><creatorcontrib>Li, Guangzhe</creatorcontrib><creatorcontrib>Han, Chunji</creatorcontrib><creatorcontrib>Sun, Lianping</creatorcontrib><creatorcontrib>Zhao, Rongjie</creatorcontrib><creatorcontrib>Cui, Santian</creatorcontrib><creatorcontrib>Hygiene</creatorcontrib><creatorcontrib>aDepartment of Preventive Medicine</creatorcontrib><creatorcontrib>cDepartment of Pharmacology</creatorcontrib><creatorcontrib>Yanbian University Medicine College</creatorcontrib><creatorcontrib>Yanbian Brain Hospital</creatorcontrib><creatorcontrib>bDepartment of Psychiatry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Yanji</au><au>Li, Guangzhe</au><au>Han, Chunji</au><au>Sun, Lianping</au><au>Zhao, Rongjie</au><au>Cui, Santian</au><aucorp>Hygiene</aucorp><aucorp>aDepartment of Preventive Medicine</aucorp><aucorp>cDepartment of Pharmacology</aucorp><aucorp>Yanbian University Medicine College</aucorp><aucorp>Yanbian Brain Hospital</aucorp><aucorp>bDepartment of Psychiatry</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Effects of Hippophae rhamnoides L. Juice on Lead-Induced Neurotoxicity in Mice</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>28</volume><issue>3</issue><spage>490</spage><epage>494</epage><pages>490-494</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>We examined the effect of Hippophae rhamnoides L. (HRL) juice on lead-induced memory impairment and neuronal damage in the brains of adult mice. Kunming mice were exposed to lead acetate 10 mg/kg body weight for 20 d. Twenty percent and 40% HRL prevented the lead-induced decrease in step-through latency. In the water maze test, the swimming time was lengthened in mice treated with lead acetate, but this time was decreased in mice that received 20% and 40% HRL. The malondialdehyde (MDA) levels were increased in lead-treated mice, which were reduced by 20% and 40% HRL in dose-dependent manner. The activities of acetylcholinesterase (AchE) and monoamine oxidase-A and -B were significantly increased in the lead-treated group, which were decreased by 40% HRL but not by 20% HRL. The levels of norepinephrine, serotonin, and 5-hydroxyindole acetic acid were decreased significantly in the lead-treated mice, and the decreases were antagonized by 40% HRL, except for than in dopamine, but 20% HRL had no effect on this change. These data suggest that the different doses of the HRL juice protect against the lead acetate-induced deficits in learning and memory and changes in neurobiochemical parameters.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>15744075</pmid><doi>10.1248/bpb.28.490</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acetylcholinesterase Animals Avoidance Learning - drug effects Avoidance Learning - physiology Brain - drug effects Brain - metabolism Female Fruit Hippophae Hippophae rhamnoides L lead Lead Poisoning, Nervous System - metabolism Lead Poisoning, Nervous System - prevention & control Male malondialdehyde memory deficit Mice monoamine oxidase Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use neurotransmitter Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Oils - isolation & purification Plant Oils - pharmacology Plant Oils - therapeutic use |
| title | Protective Effects of Hippophae rhamnoides L. Juice on Lead-Induced Neurotoxicity in Mice |
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