Hepatic glutathione contributes to attenuation of thioacetamide-induced hepatic necrosis due to suppression of oxidative stress in diet-induced obese mice

We previously reported that hepatic necrosis induced by thioacetamide (TA), a hepatotoxicant, was attenuated in mice fed a high-fat diet (HFD mice) in comparison with mice fed a normal rodent diet (ND mice). In this study, we focused on investigation of the mechanism of the attenuation. Hepatic cont...

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Veröffentlicht in:Journal of toxicological sciences 2015/08/01, Vol.40(4), pp.509-521
Hauptverfasser: Shirai, Makoto, Matsuoka, Miho, Makino, Toshihiko, Kai, Kiyonori, Teranishi, Munehiro, Takasaki, Wataru
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Sprache:eng
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