The basophil surface marker CD203c identifies Aspergillus species sensitization in patients with cystic fibrosis

Background Colonization by Aspergillus fumigatus in patients with cystic fibrosis (CF) can cause A fumigatus sensitization and/or allergic bronchopulmonary aspergillosis (ABPA), which affects pulmonary function and clinical outcomes. Recent studies show that specific allergens upregulate the surface...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2016-02, Vol.137 (2), p.436-443.e9
Hauptverfasser:	Mirković, Bojana, PhD, Lavelle, Gillian M., BSc, Azim, Ahmed Abdul, MB, BCh, BAO, Helma, Kristine, MD, Gargoum, Fatma S., MD, Molloy, Kevin, MB, BCh, BAO, Gernez, Yael, MD, PhD, Dunne, Katie, PhD, Renwick, Julie, PhD, Murphy, Philip, MD, Moss, Richard B., MD, Greene, Catherine M., PhD, Gunaratnam, Cedric, MB, Chotirmall, Sanjay H., MD, PhD, McElvaney, Noel G., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic bronchopulmonary aspergillosis Allergy and Immunology Antibody Specificity - immunology Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Antigens, Fungal - immunology Antigens, Surface - metabolism Aspergillosis - diagnosis Aspergillosis - drug therapy Aspergillosis - etiology Aspergillosis - metabolism Aspergillus - immunology Aspergillus fumigatus basophil activation test Basophils - immunology Basophils - metabolism Biomarkers Body Mass Index CD203c Classification Clinical outcomes Cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - physiopathology Female FEV1 Flow cytometry Food allergies Forced Expiratory Volume Fungi Humans Immunoglobulin E - blood Immunoglobulin E - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Immunophenotyping itraconazole Leukocyte Count Male Patients Phosphoric Diester Hydrolases - metabolism Prospective Studies Pyrophosphatases - metabolism sensitization Software upgrading Sputum - immunology Sputum - microbiology Statistical analysis Transplants & implants Values
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