Dual-task-related neural connectivity changes in patients with Parkinson’ disease
Highlights • Motor control areas involved in dual-tasking show altered functional connectivity in patients with Parkinson’s disease. • Hyper-connectivity involving the precuneus related to worse dual-task performance in freezers. • Hypo-connectivity within the basal ganglia points to a role for dopa...
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| Veröffentlicht in: | Neuroscience 2016-03, Vol.317, p.36-46 |
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| container_title | Neuroscience |
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| creator | Vervoort, G Heremans, E Bengevoord, A Strouwen, C Nackaerts, E Vandenberghe, W Nieuwboer, A |
| description | Highlights • Motor control areas involved in dual-tasking show altered functional connectivity in patients with Parkinson’s disease. • Hyper-connectivity involving the precuneus related to worse dual-task performance in freezers. • Hypo-connectivity within the basal ganglia points to a role for dopamine depletion in dual-task impairment in freezers. • Other functional connectivity patterns underscore executive impairment and loss of automaticity related to freezing of gait. |
| doi_str_mv | 10.1016/j.neuroscience.2015.12.056 |
| format | Article |
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| subjects | Aged Brain - blood supply Brain - pathology Case-Control Studies Cognition Disorders - etiology dual-tasking Female freezing of gait Functional Laterality Gait Disorders, Neurologic - etiology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Multivariate Analysis Neural Pathways - blood supply Neural Pathways - pathology Neurology Neuropsychological Tests Oxygen - blood Parkinson Disease - complications Parkinson Disease - pathology Parkinson’s disease resting-state fMRI Statistics as Topic |
| title | Dual-task-related neural connectivity changes in patients with Parkinson’ disease |
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