Alpha-lipoic acid protects against cadmium-induced hepatotoxicity via calcium signalling and gap junctional intercellular communication in rat hepatocytes

This study investigated the protective effect of alpha-lipoic acid (LA) on cadmium (Cd)-induced hepatotoxicity in BRL 3A rat liver cells. We demonstrated that LA ameliorated Cd-induced cellular injury in cell viability and nuclear fragmentation in BRL 3A cells. Furthermore, LA markedly ameliorated C...

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Veröffentlicht in:	Journal of toxicological sciences 2015/08/01, Vol.40(4), pp.469-477
Hauptverfasser:	Zou, Hui, Liu, Xuezhong, Han, Tao, Hu, Di, Yuan, Yan, Gu, Jianhong, Bian, Jianchun, Liu, Zongping
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-lipoic acid Animals Cadmium Cadmium - toxicity Calcium Calcium - metabolism Calcium Signaling - drug effects Calmodulin Cell Communication - drug effects Cell Survival - drug effects Cells, Cultured Connexin Gap Junctions - drug effects Gap Junctions - physiology Hepatocytes - drug effects Hepatocytes - physiology Hepatotoxicity Rats Thioctic Acid - pharmacology
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