Local delivery of the Neuregulin1 receptor ecto-domain (ecto-ErbB4) has a positive effect on regenerated nerve fiber maturation
The Neuregulin/ErbB system plays an important role in the peripheral nervous system, under both normal and pathological conditions. We previously demonstrated that expression of soluble ecto-ErbB4, the released extracellular fragment of the ErbB4 receptor, stimulated glial cell migration in vitro ....
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| Veröffentlicht in: | Gene therapy 2015-11, Vol.22 (11), p.901-907 |
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| creator | Gambarotta, G Pascal, D Ronchi, G Morano, M Jager, S B Moimas, S Zentilin, L Giacca, M Perroteau, I Tos, P Geuna, S Raimondo, S |
| description | The Neuregulin/ErbB system plays an important role in the peripheral nervous system, under both normal and pathological conditions. We previously demonstrated that expression of soluble ecto-ErbB4, the released extracellular fragment of the ErbB4 receptor, stimulated glial cell migration
in vitro
. In this study we examined the possibility of manipulating this system
in vivo
in order to improve injured peripheral nerve regeneration. Transected rat median nerves of adult female Wistar rats were repaired with a 10-mm-long graft made by muscle-in-vein combined nerve guide previously transduced with either the adeno-associated viral (AAV) vector AAV2-LacZ or AAV2-ecto-ErbB4. Autologous nerve grafts were used as control. Both stereological and functional analyses were performed to assess nerve regeneration. Data show that delivery of soluble ecto-ErbB4 by gene transfer in the muscle-in-vein combined nerve guide has a positive effect on fiber maturation, suggesting that it could represent a potential tool for improving peripheral nerve regeneration. |
| doi_str_mv | 10.1038/gt.2015.46 |
| format | Article |
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in vitro
. In this study we examined the possibility of manipulating this system
in vivo
in order to improve injured peripheral nerve regeneration. Transected rat median nerves of adult female Wistar rats were repaired with a 10-mm-long graft made by muscle-in-vein combined nerve guide previously transduced with either the adeno-associated viral (AAV) vector AAV2-LacZ or AAV2-ecto-ErbB4. Autologous nerve grafts were used as control. Both stereological and functional analyses were performed to assess nerve regeneration. Data show that delivery of soluble ecto-ErbB4 by gene transfer in the muscle-in-vein combined nerve guide has a positive effect on fiber maturation, suggesting that it could represent a potential tool for improving peripheral nerve regeneration.</description><identifier>ISSN: 0969-7128</identifier><identifier>EISSN: 1476-5462</identifier><identifier>DOI: 10.1038/gt.2015.46</identifier><identifier>PMID: 25938193</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14/63 ; 42/44 ; 631/378/1959 ; 692/699/578 ; 82 ; Adeno-associated virus ; Analysis ; Animals ; Autografts ; Axons - physiology ; Biomedical and Life Sciences ; Biomedicine ; Cell adhesion & migration ; Cell Biology ; Cell migration ; Dependovirus - genetics ; ErbB protein ; ErbB-2 protein ; Female ; Gene Expression ; Gene Therapy ; Gene transfer ; Genes ; Genetic Therapy - methods ; Genetic Vectors - administration & dosage ; Genetic Vectors - genetics ; Human Genetics ; Nanotechnology ; Nerve Fibers - physiology ; Nerve Regeneration - genetics ; Nerve Regeneration - physiology ; Nervous system ; Neuregulin ; Neurons ; Neurosurgical Procedures - methods ; original-article ; Peripheral Nerve Injuries - genetics ; Peripheral Nerve Injuries - metabolism ; Peripheral Nerve Injuries - therapy ; Peripheral nerves ; Peripheral Nerves - physiology ; Protein Structure, Tertiary ; Rats ; Rats, Wistar ; Receptor, ErbB-4 - biosynthesis ; Receptor, ErbB-4 - genetics ; Regeneration ; Rodents</subject><ispartof>Gene therapy, 2015-11, Vol.22 (11), p.901-907</ispartof><rights>Macmillan Publishers Limited 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2015</rights><rights>Macmillan Publishers Limited 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-556098e11f6df60daf7373592daf792a7a006f7d0eda412cac185a2c198317343</citedby><cites>FETCH-LOGICAL-c611t-556098e11f6df60daf7373592daf792a7a006f7d0eda412cac185a2c198317343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/gt.2015.46$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/gt.2015.46$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25938193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gambarotta, G</creatorcontrib><creatorcontrib>Pascal, D</creatorcontrib><creatorcontrib>Ronchi, G</creatorcontrib><creatorcontrib>Morano, M</creatorcontrib><creatorcontrib>Jager, S B</creatorcontrib><creatorcontrib>Moimas, S</creatorcontrib><creatorcontrib>Zentilin, L</creatorcontrib><creatorcontrib>Giacca, M</creatorcontrib><creatorcontrib>Perroteau, I</creatorcontrib><creatorcontrib>Tos, P</creatorcontrib><creatorcontrib>Geuna, S</creatorcontrib><creatorcontrib>Raimondo, S</creatorcontrib><title>Local delivery of the Neuregulin1 receptor ecto-domain (ecto-ErbB4) has a positive effect on regenerated nerve fiber maturation</title><title>Gene therapy</title><addtitle>Gene Ther</addtitle><addtitle>Gene Ther</addtitle><description>The Neuregulin/ErbB system plays an important role in the peripheral nervous system, under both normal and pathological conditions. We previously demonstrated that expression of soluble ecto-ErbB4, the released extracellular fragment of the ErbB4 receptor, stimulated glial cell migration
in vitro
. In this study we examined the possibility of manipulating this system
in vivo
in order to improve injured peripheral nerve regeneration. Transected rat median nerves of adult female Wistar rats were repaired with a 10-mm-long graft made by muscle-in-vein combined nerve guide previously transduced with either the adeno-associated viral (AAV) vector AAV2-LacZ or AAV2-ecto-ErbB4. Autologous nerve grafts were used as control. Both stereological and functional analyses were performed to assess nerve regeneration. Data show that delivery of soluble ecto-ErbB4 by gene transfer in the muscle-in-vein combined nerve guide has a positive effect on fiber maturation, suggesting that it could represent a potential tool for improving peripheral nerve regeneration.</description><subject>14/63</subject><subject>42/44</subject><subject>631/378/1959</subject><subject>692/699/578</subject><subject>82</subject><subject>Adeno-associated virus</subject><subject>Analysis</subject><subject>Animals</subject><subject>Autografts</subject><subject>Axons - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell adhesion & migration</subject><subject>Cell Biology</subject><subject>Cell migration</subject><subject>Dependovirus - genetics</subject><subject>ErbB protein</subject><subject>ErbB-2 protein</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gene Therapy</subject><subject>Gene transfer</subject><subject>Genes</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Vectors - administration & dosage</subject><subject>Genetic Vectors - genetics</subject><subject>Human Genetics</subject><subject>Nanotechnology</subject><subject>Nerve Fibers - physiology</subject><subject>Nerve Regeneration - genetics</subject><subject>Nerve Regeneration - physiology</subject><subject>Nervous system</subject><subject>Neuregulin</subject><subject>Neurons</subject><subject>Neurosurgical Procedures - methods</subject><subject>original-article</subject><subject>Peripheral Nerve Injuries - genetics</subject><subject>Peripheral Nerve Injuries - metabolism</subject><subject>Peripheral Nerve Injuries - therapy</subject><subject>Peripheral nerves</subject><subject>Peripheral Nerves - physiology</subject><subject>Protein Structure, Tertiary</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor, ErbB-4 - biosynthesis</subject><subject>Receptor, ErbB-4 - genetics</subject><subject>Regeneration</subject><subject>Rodents</subject><issn>0969-7128</issn><issn>1476-5462</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkl9rFDEUxQdRbK2--AEkIEirzJqbzCSTx1qqFhYF_zyHbOZmdsrsZJtkxD751c24VbsK4tNNcn73JCfcongMdAGUNy-7tGAU6kUl7hSHUElR1pVgd4tDqoQqJbDmoHgQ4yWltJINu18csFrxBhQ_LL4tvTUDaXHov2C4Jt6RtEbyDqeA3TT0I5CAFrfJB4I2-bL1G9OP5PjH5jysXlUnZG0iMWTrY5-yC0Hnskr8mFs7HDGYhC3JNWuuX2EgG5OmfNr78WFxz5kh4qObelR8fn3-6extuXz_5uLsdFlaAZDKuhZUNQjgROsEbY2TXPJasXmlmJGGUuFkS7E1FTBrLDS1YRZUw0Hyih8VxzvfbfBXE8akN320OAxmRD9FDVLUqmFKyP9As2UjckdGn_6BXvopjDmIZpyDgFoq-BcFkuUXigr4b6ozA-p-dD4FY-er9akAymgtOcvUyR5l_Zjwa-rMFKO--Phhn312i12jGdI6-mGa_z3ug893oA0-xoBOb0O_MeFaA9XziOku6XnEdDVnfnKTZlptsP2F_pypDLzYATFLY4fhVty_7b4Dt2_VPA</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Gambarotta, G</creator><creator>Pascal, D</creator><creator>Ronchi, G</creator><creator>Morano, M</creator><creator>Jager, S B</creator><creator>Moimas, S</creator><creator>Zentilin, L</creator><creator>Giacca, M</creator><creator>Perroteau, I</creator><creator>Tos, P</creator><creator>Geuna, S</creator><creator>Raimondo, S</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20151101</creationdate><title>Local delivery of the Neuregulin1 receptor ecto-domain (ecto-ErbB4) has a positive effect on regenerated nerve fiber maturation</title><author>Gambarotta, G ; Pascal, D ; Ronchi, G ; Morano, M ; Jager, S B ; Moimas, S ; Zentilin, L ; Giacca, M ; Perroteau, I ; Tos, P ; Geuna, S ; Raimondo, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-556098e11f6df60daf7373592daf792a7a006f7d0eda412cac185a2c198317343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>14/63</topic><topic>42/44</topic><topic>631/378/1959</topic><topic>692/699/578</topic><topic>82</topic><topic>Adeno-associated virus</topic><topic>Analysis</topic><topic>Animals</topic><topic>Autografts</topic><topic>Axons - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Gene therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gambarotta, G</au><au>Pascal, D</au><au>Ronchi, G</au><au>Morano, M</au><au>Jager, S B</au><au>Moimas, S</au><au>Zentilin, L</au><au>Giacca, M</au><au>Perroteau, I</au><au>Tos, P</au><au>Geuna, S</au><au>Raimondo, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local delivery of the Neuregulin1 receptor ecto-domain (ecto-ErbB4) has a positive effect on regenerated nerve fiber maturation</atitle><jtitle>Gene therapy</jtitle><stitle>Gene Ther</stitle><addtitle>Gene Ther</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>22</volume><issue>11</issue><spage>901</spage><epage>907</epage><pages>901-907</pages><issn>0969-7128</issn><eissn>1476-5462</eissn><abstract>The Neuregulin/ErbB system plays an important role in the peripheral nervous system, under both normal and pathological conditions. We previously demonstrated that expression of soluble ecto-ErbB4, the released extracellular fragment of the ErbB4 receptor, stimulated glial cell migration
in vitro
. In this study we examined the possibility of manipulating this system
in vivo
in order to improve injured peripheral nerve regeneration. Transected rat median nerves of adult female Wistar rats were repaired with a 10-mm-long graft made by muscle-in-vein combined nerve guide previously transduced with either the adeno-associated viral (AAV) vector AAV2-LacZ or AAV2-ecto-ErbB4. Autologous nerve grafts were used as control. Both stereological and functional analyses were performed to assess nerve regeneration. Data show that delivery of soluble ecto-ErbB4 by gene transfer in the muscle-in-vein combined nerve guide has a positive effect on fiber maturation, suggesting that it could represent a potential tool for improving peripheral nerve regeneration.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25938193</pmid><doi>10.1038/gt.2015.46</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0969-7128 |
| ispartof | Gene therapy, 2015-11, Vol.22 (11), p.901-907 |
| issn | 0969-7128 1476-5462 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1765982967 |
| source | MEDLINE; SpringerLink Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | 14/63 42/44 631/378/1959 692/699/578 82 Adeno-associated virus Analysis Animals Autografts Axons - physiology Biomedical and Life Sciences Biomedicine Cell adhesion & migration Cell Biology Cell migration Dependovirus - genetics ErbB protein ErbB-2 protein Female Gene Expression Gene Therapy Gene transfer Genes Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Human Genetics Nanotechnology Nerve Fibers - physiology Nerve Regeneration - genetics Nerve Regeneration - physiology Nervous system Neuregulin Neurons Neurosurgical Procedures - methods original-article Peripheral Nerve Injuries - genetics Peripheral Nerve Injuries - metabolism Peripheral Nerve Injuries - therapy Peripheral nerves Peripheral Nerves - physiology Protein Structure, Tertiary Rats Rats, Wistar Receptor, ErbB-4 - biosynthesis Receptor, ErbB-4 - genetics Regeneration Rodents |
| title | Local delivery of the Neuregulin1 receptor ecto-domain (ecto-ErbB4) has a positive effect on regenerated nerve fiber maturation |
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