De Novo Acute Myeloid Leukemia in Adults: Suppression of MicroRNA-223 is Independent of LMO2 Protein Expression BUT Associate With Adverse Cytogenetic Profile and Undifferentiated Blast Morphology

MicroRNA (MIR) signatures are critical to pathobiology and prognosis of acute myeloid leukemia (AML). MIR223 is expressed at low levels in progenitor cells, whereas high expression is induced by granulocytic differentiation. Novel-targeted therapies through epigenetic manipulation of MIR223 regulato...

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Veröffentlicht in:	Applied immunohistochemistry & molecular morphology 2015-11, Vol.23 (10), p.733-739
Hauptverfasser:	Akhter, Ariz, Patel, Jay L, Farooq, Fahad, Qureshi, Abid, Taher-Rad, Meer-Shahbani, Elyamany, Ghaleb, Al-Zahrani, Ali M, Rashid-Kolvear, Fariborz, Mansoor, Adnan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - biosynthesis Adaptor Proteins, Signal Transducing - genetics Adolescent Adult Aged Aged, 80 and over Chromosome Aberrations Disease-Free Survival Female Gene Expression Regulation, Leukemic Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology LIM Domain Proteins - biosynthesis LIM Domain Proteins - genetics Male MicroRNAs - biosynthesis MicroRNAs - genetics Middle Aged Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Retrospective Studies RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics Survival Rate
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