Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification

Cancer is associated with strong changes in lipid metabolism. For instance, normal cells take up fatty acids (FAs) from the circulation, while tumour cells generate their own and become dependent on de novo FA synthesis, which could provide a vulnerability to target tumour cells. Betulinic acid (Bet...

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Veröffentlicht in:	Oncogene 2016-01, Vol.35 (4), p.427-437
Hauptverfasser:	Potze, L, Di Franco, S, Grandela, C, Pras-Raves, M L, Picavet, D I, van Veen, H A, van Lenthe, H, Mullauer, F B, van der Wel, N N, Luyf, A, van Kampen, A H C, Kemp, S, Everts, V, Kessler, J H, Vaz, F M, Medema, J P
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 13 14/19 14/28 14/63 631/67/1059/99 96/106 96/2 96/31 Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Cancer Cardiolipin Cardiolipins - metabolism Cell Biology Cell death Cell Death - drug effects Cell Line - drug effects Cell Line - metabolism Cytochromes c - metabolism Enzymes Fatty Acids - metabolism Genetic aspects Health aspects Human Genetics Humans Internal Medicine Lipid metabolism Lipids Medicine Medicine & Public Health Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Oncology original-article Physiological aspects Stearoyl-CoA Desaturase - metabolism Terpenoids Triterpenes - pharmacology
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