Serum Levels of Thioredoxin Are Associated with Stroke Risk, Severity, and Lesion Volumes
Oxidative stress increases serum thioredoxin (TRX), a redox-regulating protein with antioxidant activity recognized as an oxidative stress marker. The aim of this study was to assess the clinical significance of serum TRX levels in Chinese patients with acute ischemic stroke (AIS). From January 1, 2...
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| Veröffentlicht in: | Molecular neurobiology 2016-01, Vol.53 (1), p.677-685 |
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| creator | Wu, Meng-Hai Song, Fang-Yu Wei, Li-Ping Meng, Zhao-Yun Zhang, Zhi-Qiang Qi, Qin-De |
| description | Oxidative stress increases serum thioredoxin (TRX), a redox-regulating protein with antioxidant activity recognized as an oxidative stress marker. The aim of this study was to assess the clinical significance of serum TRX levels in Chinese patients with acute ischemic stroke (AIS). From January 1, 2012, to December 31, 2013, all patients with first-ever acute ischemic stroke were recruited to participate in the study. Serum levels of TRX were assayed with solid-phase sandwich enzyme-linked immunosorbent assay (ELISA), and the severity of stroke was evaluated with the National Institutes of Health Stroke Scale (NIHSS) score on admission. The results indicated that the median serum TRX levels were significantly (
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| doi_str_mv | 10.1007/s12035-014-9016-y |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1765976898</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3913261181</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-98e68e081c187a319a677a158baca037e73b07cdbdfccfede153f18f2587fe513</originalsourceid><addsrcrecordid>eNqNkUFrFTEQx4Mo9ln9AF4k4MVDV2eSzSY5PkqtwgPBVwVPIW931qbd3dRkV_u-vSmvigiCpznM7_8fhh9jzxFeI4B-k1GAVBVgXVnApto_YCtUylaIRjxkKzBWVrqpzRF7kvMVgBAI-jE7EkoJAJAr9mVLaRn5hr7TkHns-cVliIm6eBsmvk7E1znHNviZOv4jzJd8O6d4TfxjyNcnfFtiKcz7E-6nrpTkECf-OQ7LSPkpe9T7IdOz-3nMPr09uzh9V20-nL8_XW-qtpZmrqyhxhAYbNFoL9H6RmuPyux860Fq0nIHuu12Xd-2PXWESvZoeqGM7kmhPGavDr03KX5bKM9uDLmlYfATxSU71I2yujHW_A8Kxgih6oK-_Au9ikuayiOFUtKq2mpRKDxQbYo5J-rdTQqjT3uH4O4UuYMiVxS5O0VuXzIv7puX3Ujd78QvJwUQByCX1fSV0h-n_9n6E9jVmzY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1753954972</pqid></control><display><type>article</type><title>Serum Levels of Thioredoxin Are Associated with Stroke Risk, Severity, and Lesion Volumes</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Wu, Meng-Hai ; Song, Fang-Yu ; Wei, Li-Ping ; Meng, Zhao-Yun ; Zhang, Zhi-Qiang ; Qi, Qin-De</creator><creatorcontrib>Wu, Meng-Hai ; Song, Fang-Yu ; Wei, Li-Ping ; Meng, Zhao-Yun ; Zhang, Zhi-Qiang ; Qi, Qin-De</creatorcontrib><description>Oxidative stress increases serum thioredoxin (TRX), a redox-regulating protein with antioxidant activity recognized as an oxidative stress marker. The aim of this study was to assess the clinical significance of serum TRX levels in Chinese patients with acute ischemic stroke (AIS). From January 1, 2012, to December 31, 2013, all patients with first-ever acute ischemic stroke were recruited to participate in the study. Serum levels of TRX were assayed with solid-phase sandwich enzyme-linked immunosorbent assay (ELISA), and the severity of stroke was evaluated with the National Institutes of Health Stroke Scale (NIHSS) score on admission. The results indicated that the median serum TRX levels were significantly (
P
< 0.0001) higher in stroke patients as compared to normal cases [15.03 ng/mL (interquartile range (IQR), 10.21–32.42) and 8.95 ng/mL (6.79–11.05), respectively]. We found the serum TRX reflected the disease severity of AIS. There was a significant positive association between serum TRX levels and NIHSS scores (
r
= 0.476,
P
< 0.0001). After adjusting for all other possible covariates, TRX remained as an independent marker of AIS with an adjusted OR of 1.245 (95 % confidence interval (CI), 1.164–1.352;
P
< 0.0001). Based on the receiver operating characteristic (ROC) curve, the optimal cutoff value of serum TRX levels as an indicator for auxiliary diagnosis of AIS was projected to be 11.0 ng/mL, which yielded a sensitivity of 80.3 % and a specificity of 73.7 %, with the area under the curve at 0.807 (95 % CI, 0.766–0.847). Further, in our study, we found that an increased risk of AIS was associated with serum TRX levels ≥11.0 ng/mL (adjusted OR 6.99; 95 % CI, 2.87–12.87) after adjusting for possible confounders. Our study demonstrated that serum TRX levels at admission were associated with stroke severity and lesion volumes. Elevated levels could be considered as a novel, independent diagnosis marker of AIS in a Chinese sample.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-014-9016-y</identifier><identifier>PMID: 25520003</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Biomarkers - blood ; Biomedical and Life Sciences ; Biomedicine ; Brain Ischemia - blood ; Brain Ischemia - diagnosis ; Cell Biology ; Female ; Humans ; Ischemia ; Male ; Middle Aged ; Neurobiology ; Neurology ; Neurosciences ; Oxidative stress ; Proteins ; Risk Factors ; Severity of Illness Index ; Stroke ; Stroke - blood ; Stroke - diagnosis ; Thioredoxins - blood</subject><ispartof>Molecular neurobiology, 2016-01, Vol.53 (1), p.677-685</ispartof><rights>Springer Science+Business Media New York 2014</rights><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-98e68e081c187a319a677a158baca037e73b07cdbdfccfede153f18f2587fe513</citedby><cites>FETCH-LOGICAL-c438t-98e68e081c187a319a677a158baca037e73b07cdbdfccfede153f18f2587fe513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-014-9016-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-014-9016-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25520003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Meng-Hai</creatorcontrib><creatorcontrib>Song, Fang-Yu</creatorcontrib><creatorcontrib>Wei, Li-Ping</creatorcontrib><creatorcontrib>Meng, Zhao-Yun</creatorcontrib><creatorcontrib>Zhang, Zhi-Qiang</creatorcontrib><creatorcontrib>Qi, Qin-De</creatorcontrib><title>Serum Levels of Thioredoxin Are Associated with Stroke Risk, Severity, and Lesion Volumes</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>Oxidative stress increases serum thioredoxin (TRX), a redox-regulating protein with antioxidant activity recognized as an oxidative stress marker. The aim of this study was to assess the clinical significance of serum TRX levels in Chinese patients with acute ischemic stroke (AIS). From January 1, 2012, to December 31, 2013, all patients with first-ever acute ischemic stroke were recruited to participate in the study. Serum levels of TRX were assayed with solid-phase sandwich enzyme-linked immunosorbent assay (ELISA), and the severity of stroke was evaluated with the National Institutes of Health Stroke Scale (NIHSS) score on admission. The results indicated that the median serum TRX levels were significantly (
P
< 0.0001) higher in stroke patients as compared to normal cases [15.03 ng/mL (interquartile range (IQR), 10.21–32.42) and 8.95 ng/mL (6.79–11.05), respectively]. We found the serum TRX reflected the disease severity of AIS. There was a significant positive association between serum TRX levels and NIHSS scores (
r
= 0.476,
P
< 0.0001). After adjusting for all other possible covariates, TRX remained as an independent marker of AIS with an adjusted OR of 1.245 (95 % confidence interval (CI), 1.164–1.352;
P
< 0.0001). Based on the receiver operating characteristic (ROC) curve, the optimal cutoff value of serum TRX levels as an indicator for auxiliary diagnosis of AIS was projected to be 11.0 ng/mL, which yielded a sensitivity of 80.3 % and a specificity of 73.7 %, with the area under the curve at 0.807 (95 % CI, 0.766–0.847). Further, in our study, we found that an increased risk of AIS was associated with serum TRX levels ≥11.0 ng/mL (adjusted OR 6.99; 95 % CI, 2.87–12.87) after adjusting for possible confounders. Our study demonstrated that serum TRX levels at admission were associated with stroke severity and lesion volumes. Elevated levels could be considered as a novel, independent diagnosis marker of AIS in a Chinese sample.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Ischemia - blood</subject><subject>Brain Ischemia - diagnosis</subject><subject>Cell Biology</subject><subject>Female</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Oxidative stress</subject><subject>Proteins</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Stroke</subject><subject>Stroke - blood</subject><subject>Stroke - diagnosis</subject><subject>Thioredoxins - blood</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkUFrFTEQx4Mo9ln9AF4k4MVDV2eSzSY5PkqtwgPBVwVPIW931qbd3dRkV_u-vSmvigiCpznM7_8fhh9jzxFeI4B-k1GAVBVgXVnApto_YCtUylaIRjxkKzBWVrqpzRF7kvMVgBAI-jE7EkoJAJAr9mVLaRn5hr7TkHns-cVliIm6eBsmvk7E1znHNviZOv4jzJd8O6d4TfxjyNcnfFtiKcz7E-6nrpTkECf-OQ7LSPkpe9T7IdOz-3nMPr09uzh9V20-nL8_XW-qtpZmrqyhxhAYbNFoL9H6RmuPyux860Fq0nIHuu12Xd-2PXWESvZoeqGM7kmhPGavDr03KX5bKM9uDLmlYfATxSU71I2yujHW_A8Kxgih6oK-_Au9ikuayiOFUtKq2mpRKDxQbYo5J-rdTQqjT3uH4O4UuYMiVxS5O0VuXzIv7puX3Ujd78QvJwUQByCX1fSV0h-n_9n6E9jVmzY</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Wu, Meng-Hai</creator><creator>Song, Fang-Yu</creator><creator>Wei, Li-Ping</creator><creator>Meng, Zhao-Yun</creator><creator>Zhang, Zhi-Qiang</creator><creator>Qi, Qin-De</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160101</creationdate><title>Serum Levels of Thioredoxin Are Associated with Stroke Risk, Severity, and Lesion Volumes</title><author>Wu, Meng-Hai ; Song, Fang-Yu ; Wei, Li-Ping ; Meng, Zhao-Yun ; Zhang, Zhi-Qiang ; Qi, Qin-De</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-98e68e081c187a319a677a158baca037e73b07cdbdfccfede153f18f2587fe513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain Ischemia - blood</topic><topic>Brain Ischemia - diagnosis</topic><topic>Cell Biology</topic><topic>Female</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Oxidative stress</topic><topic>Proteins</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Stroke</topic><topic>Stroke - blood</topic><topic>Stroke - diagnosis</topic><topic>Thioredoxins - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Meng-Hai</creatorcontrib><creatorcontrib>Song, Fang-Yu</creatorcontrib><creatorcontrib>Wei, Li-Ping</creatorcontrib><creatorcontrib>Meng, Zhao-Yun</creatorcontrib><creatorcontrib>Zhang, Zhi-Qiang</creatorcontrib><creatorcontrib>Qi, Qin-De</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Meng-Hai</au><au>Song, Fang-Yu</au><au>Wei, Li-Ping</au><au>Meng, Zhao-Yun</au><au>Zhang, Zhi-Qiang</au><au>Qi, Qin-De</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Levels of Thioredoxin Are Associated with Stroke Risk, Severity, and Lesion Volumes</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>53</volume><issue>1</issue><spage>677</spage><epage>685</epage><pages>677-685</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Oxidative stress increases serum thioredoxin (TRX), a redox-regulating protein with antioxidant activity recognized as an oxidative stress marker. The aim of this study was to assess the clinical significance of serum TRX levels in Chinese patients with acute ischemic stroke (AIS). From January 1, 2012, to December 31, 2013, all patients with first-ever acute ischemic stroke were recruited to participate in the study. Serum levels of TRX were assayed with solid-phase sandwich enzyme-linked immunosorbent assay (ELISA), and the severity of stroke was evaluated with the National Institutes of Health Stroke Scale (NIHSS) score on admission. The results indicated that the median serum TRX levels were significantly (
P
< 0.0001) higher in stroke patients as compared to normal cases [15.03 ng/mL (interquartile range (IQR), 10.21–32.42) and 8.95 ng/mL (6.79–11.05), respectively]. We found the serum TRX reflected the disease severity of AIS. There was a significant positive association between serum TRX levels and NIHSS scores (
r
= 0.476,
P
< 0.0001). After adjusting for all other possible covariates, TRX remained as an independent marker of AIS with an adjusted OR of 1.245 (95 % confidence interval (CI), 1.164–1.352;
P
< 0.0001). Based on the receiver operating characteristic (ROC) curve, the optimal cutoff value of serum TRX levels as an indicator for auxiliary diagnosis of AIS was projected to be 11.0 ng/mL, which yielded a sensitivity of 80.3 % and a specificity of 73.7 %, with the area under the curve at 0.807 (95 % CI, 0.766–0.847). Further, in our study, we found that an increased risk of AIS was associated with serum TRX levels ≥11.0 ng/mL (adjusted OR 6.99; 95 % CI, 2.87–12.87) after adjusting for possible confounders. Our study demonstrated that serum TRX levels at admission were associated with stroke severity and lesion volumes. Elevated levels could be considered as a novel, independent diagnosis marker of AIS in a Chinese sample.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25520003</pmid><doi>10.1007/s12035-014-9016-y</doi><tpages>9</tpages></addata></record> |
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| subjects | Aged Biomarkers - blood Biomedical and Life Sciences Biomedicine Brain Ischemia - blood Brain Ischemia - diagnosis Cell Biology Female Humans Ischemia Male Middle Aged Neurobiology Neurology Neurosciences Oxidative stress Proteins Risk Factors Severity of Illness Index Stroke Stroke - blood Stroke - diagnosis Thioredoxins - blood |
| title | Serum Levels of Thioredoxin Are Associated with Stroke Risk, Severity, and Lesion Volumes |
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