Advanced Age, High β-CTX Levels, and Impaired Renal Function are Independent Risk Factors for All-Cause One-Year Mortality in Hip Fracture Patients
Risk factors for increased mortality in hip fracture patients include older age, male sex, fracture type, bone mineral density, and pre-existing co-morbidities. The role of biochemical and other anthropometric parameters on hip fracture mortality remains unclear. The aim of this study was to identif...
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| Veröffentlicht in: | Calcified tissue international 2016-01, Vol.98 (1), p.67-75 |
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| creator | Gulin, Tonko Kruljac, Ivan Kirigin, Lora Merc, Marcela Pavić, Marina Trcin, Mirna Tominac Bokulić, Adrijana Megla, Željka Bukovec Kaštelan, Darko |
| description | Risk factors for increased mortality in hip fracture patients include older age, male sex, fracture type, bone mineral density, and pre-existing co-morbidities. The role of biochemical and other anthropometric parameters on hip fracture mortality remains unclear. The aim of this study was to identify the risk factors for one-year mortality in patients with hip fractures. A total of 236 consecutive patients (59 males) with hip fractures were followed over a one-year period. Patient age, gender, type of fracture, type of treatment, time from admission to surgery, type of anesthesia, body mass index, and electrocardiograms were recorded. Complete blood counts, serum electrolytes, urea, creatinine, d-dimers, calcium, phosphate, osteocalcin, and beta-isomerised C-terminal telopeptide of collagen type I (β-CTX) were measured at admission and estimated glomerular filtration rate (eGFR) was calculated. Multivariate Cox regression models were used to analyze the association of these parameters with survival. One-year mortality rate was 28.4 %. Age was independently associated with mortality (HR 1.117, 95 % CI 1.062–1.174,
P
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| doi_str_mv | 10.1007/s00223-015-0070-x |
| format | Article |
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P
< 0.001). In a multivariable model, mortality was increased in patients with higher β-CTX (HR 4.63 95 % CI 1.87–11.45,
P
= 0.001) and lower eGFR (HR 0.972, 95 % CI 0.956–0.987,
P
< 0.001). Patients younger than 84 years, with eGFR < 55.4 ml/min had ten times higher mortality rates (3.2 vs. 24.5 %, HR 9.73, 95 % CI 2.06–45.93) as well as those with β-CTX > 0.276 g/L (3.5 vs. 25.7 %, HR 9.5, 95 % CI 2.11–42.76). Advanced age, high β-CTX levels, and impaired renal function are independent risk factors of mortality in patients with hip fractures.</description><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/s00223-015-0070-x</identifier><identifier>PMID: 26453360</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Aged, 80 and over ; Aging - blood ; Aging - physiology ; Biochemistry ; Biomedical and Life Sciences ; Cause of Death ; Cell Biology ; Collagen Type I - blood ; Endocrinology ; Female ; Glomerular Filtration Rate ; Hip Fractures - blood ; Hip Fractures - complications ; Hip Fractures - mortality ; Humans ; Life Sciences ; Male ; Original Research ; Orthopedics ; Renal Insufficiency - blood ; Renal Insufficiency - complications ; Renal Insufficiency - epidemiology ; Risk Factors ; Survival Analysis</subject><ispartof>Calcified tissue international, 2016-01, Vol.98 (1), p.67-75</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-382e85153ed7ba61720982cc788995e086e6c33ea98ccbb4a72e1277ce09cc353</citedby><cites>FETCH-LOGICAL-c447t-382e85153ed7ba61720982cc788995e086e6c33ea98ccbb4a72e1277ce09cc353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00223-015-0070-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00223-015-0070-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26453360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gulin, Tonko</creatorcontrib><creatorcontrib>Kruljac, Ivan</creatorcontrib><creatorcontrib>Kirigin, Lora</creatorcontrib><creatorcontrib>Merc, Marcela</creatorcontrib><creatorcontrib>Pavić, Marina</creatorcontrib><creatorcontrib>Trcin, Mirna Tominac</creatorcontrib><creatorcontrib>Bokulić, Adrijana</creatorcontrib><creatorcontrib>Megla, Željka Bukovec</creatorcontrib><creatorcontrib>Kaštelan, Darko</creatorcontrib><title>Advanced Age, High β-CTX Levels, and Impaired Renal Function are Independent Risk Factors for All-Cause One-Year Mortality in Hip Fracture Patients</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><addtitle>Calcif Tissue Int</addtitle><description>Risk factors for increased mortality in hip fracture patients include older age, male sex, fracture type, bone mineral density, and pre-existing co-morbidities. The role of biochemical and other anthropometric parameters on hip fracture mortality remains unclear. The aim of this study was to identify the risk factors for one-year mortality in patients with hip fractures. A total of 236 consecutive patients (59 males) with hip fractures were followed over a one-year period. Patient age, gender, type of fracture, type of treatment, time from admission to surgery, type of anesthesia, body mass index, and electrocardiograms were recorded. Complete blood counts, serum electrolytes, urea, creatinine, d-dimers, calcium, phosphate, osteocalcin, and beta-isomerised C-terminal telopeptide of collagen type I (β-CTX) were measured at admission and estimated glomerular filtration rate (eGFR) was calculated. Multivariate Cox regression models were used to analyze the association of these parameters with survival. One-year mortality rate was 28.4 %. Age was independently associated with mortality (HR 1.117, 95 % CI 1.062–1.174,
P
< 0.001). In a multivariable model, mortality was increased in patients with higher β-CTX (HR 4.63 95 % CI 1.87–11.45,
P
= 0.001) and lower eGFR (HR 0.972, 95 % CI 0.956–0.987,
P
< 0.001). Patients younger than 84 years, with eGFR < 55.4 ml/min had ten times higher mortality rates (3.2 vs. 24.5 %, HR 9.73, 95 % CI 2.06–45.93) as well as those with β-CTX > 0.276 g/L (3.5 vs. 25.7 %, HR 9.5, 95 % CI 2.11–42.76). Advanced age, high β-CTX levels, and impaired renal function are independent risk factors of mortality in patients with hip fractures.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - blood</subject><subject>Aging - physiology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cause of Death</subject><subject>Cell Biology</subject><subject>Collagen Type I - blood</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Hip Fractures - blood</subject><subject>Hip Fractures - complications</subject><subject>Hip Fractures - mortality</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Original Research</subject><subject>Orthopedics</subject><subject>Renal Insufficiency - blood</subject><subject>Renal Insufficiency - complications</subject><subject>Renal Insufficiency - epidemiology</subject><subject>Risk Factors</subject><subject>Survival Analysis</subject><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFOGzEUhi1UVFLoAdhUXnaB22d7xp5ZRhEpkVKBEEiwshzPS2o68UztGQT36El6EM6EUWiXFRs_We_7f1v6CDnm8IUD6K8JQAjJgJcsX4E97JEJL6RgUAn9jkyAa85qpW8OyIeU7gB4oZR6Tw6EKkopFUzI72lzb4PDhk43eELP_OYHffrDZlc3dIn32KYTakNDF9ve-pipSwy2pfMxuMF3gdqIdBEa7DEfYaCXPv2kc-uGLia67iKdti2b2TEhPQ_IbtFG-r2Lg2398Eh9yA_2dB5zYMxNF3bwuSUdkf21bRN-fJ2H5Hp-ejU7Y8vzb4vZdMlcUeiByUpgVfJSYqNXVnEtoK6Ec7qq6rpEqBQqJyXaunJutSqsFsiF1g6hdk6W8pB83vX2sfs1YhrM1ieHbWsDdmMyXKuy1kpLeAsKNfD8mYzyHepil1LEtemj39r4aDiYF29m581kb-bFm3nImU-v9eNqi82_xF9RGRA7IOVV2GA0d90Ys4v0n9Zn1m2jGA</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Gulin, Tonko</creator><creator>Kruljac, Ivan</creator><creator>Kirigin, Lora</creator><creator>Merc, Marcela</creator><creator>Pavić, Marina</creator><creator>Trcin, Mirna Tominac</creator><creator>Bokulić, Adrijana</creator><creator>Megla, Željka Bukovec</creator><creator>Kaštelan, Darko</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20160101</creationdate><title>Advanced Age, High β-CTX Levels, and Impaired Renal Function are Independent Risk Factors for All-Cause One-Year Mortality in Hip Fracture Patients</title><author>Gulin, Tonko ; Kruljac, Ivan ; Kirigin, Lora ; Merc, Marcela ; Pavić, Marina ; Trcin, Mirna Tominac ; Bokulić, Adrijana ; Megla, Željka Bukovec ; Kaštelan, Darko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-382e85153ed7ba61720982cc788995e086e6c33ea98ccbb4a72e1277ce09cc353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - blood</topic><topic>Aging - physiology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cause of Death</topic><topic>Cell Biology</topic><topic>Collagen Type I - blood</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Hip Fractures - blood</topic><topic>Hip Fractures - complications</topic><topic>Hip Fractures - mortality</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Original Research</topic><topic>Orthopedics</topic><topic>Renal Insufficiency - blood</topic><topic>Renal Insufficiency - complications</topic><topic>Renal Insufficiency - epidemiology</topic><topic>Risk Factors</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gulin, Tonko</creatorcontrib><creatorcontrib>Kruljac, Ivan</creatorcontrib><creatorcontrib>Kirigin, Lora</creatorcontrib><creatorcontrib>Merc, Marcela</creatorcontrib><creatorcontrib>Pavić, Marina</creatorcontrib><creatorcontrib>Trcin, Mirna Tominac</creatorcontrib><creatorcontrib>Bokulić, Adrijana</creatorcontrib><creatorcontrib>Megla, Željka Bukovec</creatorcontrib><creatorcontrib>Kaštelan, Darko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Calcified tissue international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gulin, Tonko</au><au>Kruljac, Ivan</au><au>Kirigin, Lora</au><au>Merc, Marcela</au><au>Pavić, Marina</au><au>Trcin, Mirna Tominac</au><au>Bokulić, Adrijana</au><au>Megla, Željka Bukovec</au><au>Kaštelan, Darko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advanced Age, High β-CTX Levels, and Impaired Renal Function are Independent Risk Factors for All-Cause One-Year Mortality in Hip Fracture Patients</atitle><jtitle>Calcified tissue international</jtitle><stitle>Calcif Tissue Int</stitle><addtitle>Calcif Tissue Int</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>98</volume><issue>1</issue><spage>67</spage><epage>75</epage><pages>67-75</pages><issn>0171-967X</issn><eissn>1432-0827</eissn><abstract>Risk factors for increased mortality in hip fracture patients include older age, male sex, fracture type, bone mineral density, and pre-existing co-morbidities. The role of biochemical and other anthropometric parameters on hip fracture mortality remains unclear. The aim of this study was to identify the risk factors for one-year mortality in patients with hip fractures. A total of 236 consecutive patients (59 males) with hip fractures were followed over a one-year period. Patient age, gender, type of fracture, type of treatment, time from admission to surgery, type of anesthesia, body mass index, and electrocardiograms were recorded. Complete blood counts, serum electrolytes, urea, creatinine, d-dimers, calcium, phosphate, osteocalcin, and beta-isomerised C-terminal telopeptide of collagen type I (β-CTX) were measured at admission and estimated glomerular filtration rate (eGFR) was calculated. Multivariate Cox regression models were used to analyze the association of these parameters with survival. One-year mortality rate was 28.4 %. Age was independently associated with mortality (HR 1.117, 95 % CI 1.062–1.174,
P
< 0.001). In a multivariable model, mortality was increased in patients with higher β-CTX (HR 4.63 95 % CI 1.87–11.45,
P
= 0.001) and lower eGFR (HR 0.972, 95 % CI 0.956–0.987,
P
< 0.001). Patients younger than 84 years, with eGFR < 55.4 ml/min had ten times higher mortality rates (3.2 vs. 24.5 %, HR 9.73, 95 % CI 2.06–45.93) as well as those with β-CTX > 0.276 g/L (3.5 vs. 25.7 %, HR 9.5, 95 % CI 2.11–42.76). Advanced age, high β-CTX levels, and impaired renal function are independent risk factors of mortality in patients with hip fractures.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26453360</pmid><doi>10.1007/s00223-015-0070-x</doi><tpages>9</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Aging - blood Aging - physiology Biochemistry Biomedical and Life Sciences Cause of Death Cell Biology Collagen Type I - blood Endocrinology Female Glomerular Filtration Rate Hip Fractures - blood Hip Fractures - complications Hip Fractures - mortality Humans Life Sciences Male Original Research Orthopedics Renal Insufficiency - blood Renal Insufficiency - complications Renal Insufficiency - epidemiology Risk Factors Survival Analysis |
| title | Advanced Age, High β-CTX Levels, and Impaired Renal Function are Independent Risk Factors for All-Cause One-Year Mortality in Hip Fracture Patients |
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