High reactive oxygen species levels are detected at the end of the chronological life span of translocant yeast cells
Chromosome translocation is a major genomic event for a cell, affecting almost every of its life aspects ranging from metabolism, organelle maintenance and homeostasis to gene maintenance and expression. By using the bridge-induced translocation system, we defined the effects of induced chromosome t...
Gespeichert in:
| Veröffentlicht in: | Molecular genetics and genomics : MGG 2016-02, Vol.291 (1), p.423-435 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 435 |
|---|---|
| container_issue | 1 |
| container_start_page | 423 |
| container_title | Molecular genetics and genomics : MGG |
| container_volume | 291 |
| creator | Sims, Jason Bruschi, Carlo V. Bertin, Chloé West, Nicole Breitenbach, Michael Schroeder, Sabrina Eisenberg, Tobias Rinnerthaler, Mark Raspor, Peter Tosato, Valentina |
| description | Chromosome translocation is a major genomic event for a cell, affecting almost every of its life aspects ranging from metabolism, organelle maintenance and homeostasis to gene maintenance and expression. By using the bridge-induced translocation system, we defined the effects of induced chromosome translocation on the chronological life span (CLS) of yeast with particular interest to the oxidative stress condition. The results demonstrate that every translocant strain has a different CLS, but all have a high increase in reactive oxygen species and in lipid peroxides levels at the end of the life span. This could be due to the very unique and strong deregulation of the oxidative stress network. Furthermore, the loss of the translocated chromosome occurs at the end of the life span and is locus dependent. Additionally, the RDH54 gene may play a role in the correct segregation of the translocant chromosome, since in its absence there is an increase in loss of the bridge-induced translocated chromosome. |
| doi_str_mv | 10.1007/s00438-015-1120-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1765976727</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3934992601</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-8429b21971c43b102f6b2b432a21bfdd0150b483c084a46d83250e190382bf1b3</originalsourceid><addsrcrecordid>eNqNkkFv1DAQhSMEoqXwA7iAJS69BGbGjp0cUQUtUiUO0LPlOJNsqmy82NmK_fd4m1IhDoiTR5pvnuf5uSheI7xHAPMhAShZl4BViUhQNk-KU9RoSqVJPn2ssTopXqR0C4BGk3lenJBWJEHXp8X-ahw2IrLzy3jHIvw8DDyLtGM_chIT3_GUhIssOl7YL9wJt4hlw4LnToT-vvSbGOYwhWH0bhLT2HMWcPN9O7o5TcG7eREHdmkRnqcpvSye9W5K_OrhPCtuPn_6fnFVXn-9_HLx8br0qmmWslbUtISNQa9ki0C9bqlVkhxh23ddNg6tqqWHWjmlu1pSBYwNyJraHlt5VpyvursYfuw5LXY7puMGbuawTza_R9UYbcj8D4pK14Q6o-_-Qm_DPs7ZyJECQ1RpyBSulI8hpci93cVx6-LBIthjfHaNz2YX9hifbfLMmwflfbvl7nHid14ZoBVIuTUPHP-4-h-qb9eh3gXrhjgme_ONAHX-EEqbqpa_AE5JrMs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1760722560</pqid></control><display><type>article</type><title>High reactive oxygen species levels are detected at the end of the chronological life span of translocant yeast cells</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Sims, Jason ; Bruschi, Carlo V. ; Bertin, Chloé ; West, Nicole ; Breitenbach, Michael ; Schroeder, Sabrina ; Eisenberg, Tobias ; Rinnerthaler, Mark ; Raspor, Peter ; Tosato, Valentina</creator><creatorcontrib>Sims, Jason ; Bruschi, Carlo V. ; Bertin, Chloé ; West, Nicole ; Breitenbach, Michael ; Schroeder, Sabrina ; Eisenberg, Tobias ; Rinnerthaler, Mark ; Raspor, Peter ; Tosato, Valentina</creatorcontrib><description>Chromosome translocation is a major genomic event for a cell, affecting almost every of its life aspects ranging from metabolism, organelle maintenance and homeostasis to gene maintenance and expression. By using the bridge-induced translocation system, we defined the effects of induced chromosome translocation on the chronological life span (CLS) of yeast with particular interest to the oxidative stress condition. The results demonstrate that every translocant strain has a different CLS, but all have a high increase in reactive oxygen species and in lipid peroxides levels at the end of the life span. This could be due to the very unique and strong deregulation of the oxidative stress network. Furthermore, the loss of the translocated chromosome occurs at the end of the life span and is locus dependent. Additionally, the RDH54 gene may play a role in the correct segregation of the translocant chromosome, since in its absence there is an increase in loss of the bridge-induced translocated chromosome.</description><identifier>ISSN: 1617-4615</identifier><identifier>EISSN: 1617-4623</identifier><identifier>DOI: 10.1007/s00438-015-1120-9</identifier><identifier>PMID: 26423068</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aging ; Animal Genetics and Genomics ; Biochemistry ; Biology ; Biomedical and Life Sciences ; Chromosomes ; Deregulation ; Fungal Proteins - genetics ; Genes ; Genomics ; Human Genetics ; Life Sciences ; Lipid Peroxides - metabolism ; Longevity - genetics ; Microbial Genetics and Genomics ; Original Article ; Oxidative stress ; Oxidative Stress - genetics ; Plant Genetics and Genomics ; Reactive Oxygen Species - metabolism ; Translocation, Genetic - genetics ; Yeast ; Yeasts - genetics ; Yeasts - metabolism</subject><ispartof>Molecular genetics and genomics : MGG, 2016-02, Vol.291 (1), p.423-435</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-8429b21971c43b102f6b2b432a21bfdd0150b483c084a46d83250e190382bf1b3</citedby><cites>FETCH-LOGICAL-c499t-8429b21971c43b102f6b2b432a21bfdd0150b483c084a46d83250e190382bf1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00438-015-1120-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00438-015-1120-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26423068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sims, Jason</creatorcontrib><creatorcontrib>Bruschi, Carlo V.</creatorcontrib><creatorcontrib>Bertin, Chloé</creatorcontrib><creatorcontrib>West, Nicole</creatorcontrib><creatorcontrib>Breitenbach, Michael</creatorcontrib><creatorcontrib>Schroeder, Sabrina</creatorcontrib><creatorcontrib>Eisenberg, Tobias</creatorcontrib><creatorcontrib>Rinnerthaler, Mark</creatorcontrib><creatorcontrib>Raspor, Peter</creatorcontrib><creatorcontrib>Tosato, Valentina</creatorcontrib><title>High reactive oxygen species levels are detected at the end of the chronological life span of translocant yeast cells</title><title>Molecular genetics and genomics : MGG</title><addtitle>Mol Genet Genomics</addtitle><addtitle>Mol Genet Genomics</addtitle><description>Chromosome translocation is a major genomic event for a cell, affecting almost every of its life aspects ranging from metabolism, organelle maintenance and homeostasis to gene maintenance and expression. By using the bridge-induced translocation system, we defined the effects of induced chromosome translocation on the chronological life span (CLS) of yeast with particular interest to the oxidative stress condition. The results demonstrate that every translocant strain has a different CLS, but all have a high increase in reactive oxygen species and in lipid peroxides levels at the end of the life span. This could be due to the very unique and strong deregulation of the oxidative stress network. Furthermore, the loss of the translocated chromosome occurs at the end of the life span and is locus dependent. Additionally, the RDH54 gene may play a role in the correct segregation of the translocant chromosome, since in its absence there is an increase in loss of the bridge-induced translocated chromosome.</description><subject>Aging</subject><subject>Animal Genetics and Genomics</subject><subject>Biochemistry</subject><subject>Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Chromosomes</subject><subject>Deregulation</subject><subject>Fungal Proteins - genetics</subject><subject>Genes</subject><subject>Genomics</subject><subject>Human Genetics</subject><subject>Life Sciences</subject><subject>Lipid Peroxides - metabolism</subject><subject>Longevity - genetics</subject><subject>Microbial Genetics and Genomics</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - genetics</subject><subject>Plant Genetics and Genomics</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Translocation, Genetic - genetics</subject><subject>Yeast</subject><subject>Yeasts - genetics</subject><subject>Yeasts - metabolism</subject><issn>1617-4615</issn><issn>1617-4623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkkFv1DAQhSMEoqXwA7iAJS69BGbGjp0cUQUtUiUO0LPlOJNsqmy82NmK_fd4m1IhDoiTR5pvnuf5uSheI7xHAPMhAShZl4BViUhQNk-KU9RoSqVJPn2ssTopXqR0C4BGk3lenJBWJEHXp8X-ahw2IrLzy3jHIvw8DDyLtGM_chIT3_GUhIssOl7YL9wJt4hlw4LnToT-vvSbGOYwhWH0bhLT2HMWcPN9O7o5TcG7eREHdmkRnqcpvSye9W5K_OrhPCtuPn_6fnFVXn-9_HLx8br0qmmWslbUtISNQa9ki0C9bqlVkhxh23ddNg6tqqWHWjmlu1pSBYwNyJraHlt5VpyvursYfuw5LXY7puMGbuawTza_R9UYbcj8D4pK14Q6o-_-Qm_DPs7ZyJECQ1RpyBSulI8hpci93cVx6-LBIthjfHaNz2YX9hifbfLMmwflfbvl7nHid14ZoBVIuTUPHP-4-h-qb9eh3gXrhjgme_ONAHX-EEqbqpa_AE5JrMs</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Sims, Jason</creator><creator>Bruschi, Carlo V.</creator><creator>Bertin, Chloé</creator><creator>West, Nicole</creator><creator>Breitenbach, Michael</creator><creator>Schroeder, Sabrina</creator><creator>Eisenberg, Tobias</creator><creator>Rinnerthaler, Mark</creator><creator>Raspor, Peter</creator><creator>Tosato, Valentina</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20160201</creationdate><title>High reactive oxygen species levels are detected at the end of the chronological life span of translocant yeast cells</title><author>Sims, Jason ; Bruschi, Carlo V. ; Bertin, Chloé ; West, Nicole ; Breitenbach, Michael ; Schroeder, Sabrina ; Eisenberg, Tobias ; Rinnerthaler, Mark ; Raspor, Peter ; Tosato, Valentina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-8429b21971c43b102f6b2b432a21bfdd0150b483c084a46d83250e190382bf1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aging</topic><topic>Animal Genetics and Genomics</topic><topic>Biochemistry</topic><topic>Biology</topic><topic>Biomedical and Life Sciences</topic><topic>Chromosomes</topic><topic>Deregulation</topic><topic>Fungal Proteins - genetics</topic><topic>Genes</topic><topic>Genomics</topic><topic>Human Genetics</topic><topic>Life Sciences</topic><topic>Lipid Peroxides - metabolism</topic><topic>Longevity - genetics</topic><topic>Microbial Genetics and Genomics</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - genetics</topic><topic>Plant Genetics and Genomics</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Translocation, Genetic - genetics</topic><topic>Yeast</topic><topic>Yeasts - genetics</topic><topic>Yeasts - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sims, Jason</creatorcontrib><creatorcontrib>Bruschi, Carlo V.</creatorcontrib><creatorcontrib>Bertin, Chloé</creatorcontrib><creatorcontrib>West, Nicole</creatorcontrib><creatorcontrib>Breitenbach, Michael</creatorcontrib><creatorcontrib>Schroeder, Sabrina</creatorcontrib><creatorcontrib>Eisenberg, Tobias</creatorcontrib><creatorcontrib>Rinnerthaler, Mark</creatorcontrib><creatorcontrib>Raspor, Peter</creatorcontrib><creatorcontrib>Tosato, Valentina</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular genetics and genomics : MGG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sims, Jason</au><au>Bruschi, Carlo V.</au><au>Bertin, Chloé</au><au>West, Nicole</au><au>Breitenbach, Michael</au><au>Schroeder, Sabrina</au><au>Eisenberg, Tobias</au><au>Rinnerthaler, Mark</au><au>Raspor, Peter</au><au>Tosato, Valentina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High reactive oxygen species levels are detected at the end of the chronological life span of translocant yeast cells</atitle><jtitle>Molecular genetics and genomics : MGG</jtitle><stitle>Mol Genet Genomics</stitle><addtitle>Mol Genet Genomics</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>291</volume><issue>1</issue><spage>423</spage><epage>435</epage><pages>423-435</pages><issn>1617-4615</issn><eissn>1617-4623</eissn><abstract>Chromosome translocation is a major genomic event for a cell, affecting almost every of its life aspects ranging from metabolism, organelle maintenance and homeostasis to gene maintenance and expression. By using the bridge-induced translocation system, we defined the effects of induced chromosome translocation on the chronological life span (CLS) of yeast with particular interest to the oxidative stress condition. The results demonstrate that every translocant strain has a different CLS, but all have a high increase in reactive oxygen species and in lipid peroxides levels at the end of the life span. This could be due to the very unique and strong deregulation of the oxidative stress network. Furthermore, the loss of the translocated chromosome occurs at the end of the life span and is locus dependent. Additionally, the RDH54 gene may play a role in the correct segregation of the translocant chromosome, since in its absence there is an increase in loss of the bridge-induced translocated chromosome.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26423068</pmid><doi>10.1007/s00438-015-1120-9</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1617-4615 |
| ispartof | Molecular genetics and genomics : MGG, 2016-02, Vol.291 (1), p.423-435 |
| issn | 1617-4615 1617-4623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1765976727 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aging Animal Genetics and Genomics Biochemistry Biology Biomedical and Life Sciences Chromosomes Deregulation Fungal Proteins - genetics Genes Genomics Human Genetics Life Sciences Lipid Peroxides - metabolism Longevity - genetics Microbial Genetics and Genomics Original Article Oxidative stress Oxidative Stress - genetics Plant Genetics and Genomics Reactive Oxygen Species - metabolism Translocation, Genetic - genetics Yeast Yeasts - genetics Yeasts - metabolism |
| title | High reactive oxygen species levels are detected at the end of the chronological life span of translocant yeast cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T07%3A14%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20reactive%20oxygen%20species%20levels%20are%20detected%20at%20the%20end%20of%20the%20chronological%20life%20span%20of%20translocant%20yeast%20cells&rft.jtitle=Molecular%20genetics%20and%20genomics%20:%20MGG&rft.au=Sims,%20Jason&rft.date=2016-02-01&rft.volume=291&rft.issue=1&rft.spage=423&rft.epage=435&rft.pages=423-435&rft.issn=1617-4615&rft.eissn=1617-4623&rft_id=info:doi/10.1007/s00438-015-1120-9&rft_dat=%3Cproquest_cross%3E3934992601%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1760722560&rft_id=info:pmid/26423068&rfr_iscdi=true |