Association between RAD 51 rs1801320 and susceptibility to glioblastoma
Glioblastoma is the most common and aggressive malignant primary brain tumor. Despite decades of research and the advent of new therapies, patients with glioblastoma continue to have a very poor prognosis. Radiation therapy has a major role as adjuvant treatment for glioblastoma following surgical r...
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| Veröffentlicht in: | Journal of neuro-oncology 2016, Vol.126 (2), p.265-270 |
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| creator | Franceschi, S. Tomei, S. Mazzanti, C. M. Lessi, F. Aretini, P. La Ferla, M. De Gregorio, V. Pasqualetti, F. Zavaglia, K. Bevilacqua, G. Naccarato, A. G. |
| description | Glioblastoma is the most common and aggressive malignant primary brain tumor. Despite decades of research and the advent of new therapies, patients with glioblastoma continue to have a very poor prognosis. Radiation therapy has a major role as adjuvant treatment for glioblastoma following surgical resection. Many studies have shown that polymorphisms of genes involved in pathways of DNA repair may affect the sensitivity of the cells to treatment. Although the role of these polymorphisms has been investigated in relation to response to radiotherapy, their role as predisposing factors to glioblastoma has not been clarified yet. In the present study, we evaluated the association between polymorphisms in DNA repair genes, namely: XRCC1 rs25487, XRCC3 rs861539 and RAD51 rs1801320, with the susceptibility to develop glioblastoma. Eighty-five glioblastoma patients and 70 matched controls were recruited for this study. Data from the 1000 Genomes Project (98 Tuscans) were also downloaded and used for the association analysis. Subjects carrying RAD51 rs1801320 GC genotype showed an increased risk of glioblastoma (GC vs GG, χ
2
= 10.75; OR 3.0087; p = 0.0010). The C allele was also significantly associated to glioblastoma (χ
2
= 8.66; OR 2.5674; p = 0.0032). Moreover, RAD51 rs1801320 C allele increased the risk to develop glioblastoma also when combined to XRCC1 rs25487 G allele and XRCC3 rs861539 C allele (χ
2
= 6.558; p = 0.0053). |
| doi_str_mv | 10.1007/s11060-015-1974-z |
| format | Article |
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2
= 10.75; OR 3.0087; p = 0.0010). The C allele was also significantly associated to glioblastoma (χ
2
= 8.66; OR 2.5674; p = 0.0032). Moreover, RAD51 rs1801320 C allele increased the risk to develop glioblastoma also when combined to XRCC1 rs25487 G allele and XRCC3 rs861539 C allele (χ
2
= 6.558; p = 0.0053).</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-015-1974-z</identifier><identifier>PMID: 26511493</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Brain Neoplasms - genetics ; DNA Repair ; DNA-Binding Proteins - genetics ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Glioblastoma - genetics ; Humans ; Laboratory Investigation ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurology ; Oncology ; Polymorphism, Single Nucleotide ; Rad51 Recombinase - genetics ; Risk Factors ; X-ray Repair Cross Complementing Protein 1</subject><ispartof>Journal of neuro-oncology, 2016, Vol.126 (2), p.265-270</ispartof><rights>Springer Science+Business Media New York 2015</rights><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-ebe8dac3358a3d9f7d302aeea9fdd040302f598f2199acbd945c2e7b57d444d73</citedby><cites>FETCH-LOGICAL-c475t-ebe8dac3358a3d9f7d302aeea9fdd040302f598f2199acbd945c2e7b57d444d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11060-015-1974-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11060-015-1974-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26511493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Franceschi, S.</creatorcontrib><creatorcontrib>Tomei, S.</creatorcontrib><creatorcontrib>Mazzanti, C. M.</creatorcontrib><creatorcontrib>Lessi, F.</creatorcontrib><creatorcontrib>Aretini, P.</creatorcontrib><creatorcontrib>La Ferla, M.</creatorcontrib><creatorcontrib>De Gregorio, V.</creatorcontrib><creatorcontrib>Pasqualetti, F.</creatorcontrib><creatorcontrib>Zavaglia, K.</creatorcontrib><creatorcontrib>Bevilacqua, G.</creatorcontrib><creatorcontrib>Naccarato, A. G.</creatorcontrib><title>Association between RAD 51 rs1801320 and susceptibility to glioblastoma</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><addtitle>J Neurooncol</addtitle><description>Glioblastoma is the most common and aggressive malignant primary brain tumor. Despite decades of research and the advent of new therapies, patients with glioblastoma continue to have a very poor prognosis. Radiation therapy has a major role as adjuvant treatment for glioblastoma following surgical resection. Many studies have shown that polymorphisms of genes involved in pathways of DNA repair may affect the sensitivity of the cells to treatment. Although the role of these polymorphisms has been investigated in relation to response to radiotherapy, their role as predisposing factors to glioblastoma has not been clarified yet. In the present study, we evaluated the association between polymorphisms in DNA repair genes, namely: XRCC1 rs25487, XRCC3 rs861539 and RAD51 rs1801320, with the susceptibility to develop glioblastoma. Eighty-five glioblastoma patients and 70 matched controls were recruited for this study. Data from the 1000 Genomes Project (98 Tuscans) were also downloaded and used for the association analysis. Subjects carrying RAD51 rs1801320 GC genotype showed an increased risk of glioblastoma (GC vs GG, χ
2
= 10.75; OR 3.0087; p = 0.0010). The C allele was also significantly associated to glioblastoma (χ
2
= 8.66; OR 2.5674; p = 0.0032). Moreover, RAD51 rs1801320 C allele increased the risk to develop glioblastoma also when combined to XRCC1 rs25487 G allele and XRCC3 rs861539 C allele (χ
2
= 6.558; p = 0.0053).</description><subject>Aged</subject><subject>Brain Neoplasms - genetics</subject><subject>DNA Repair</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Glioblastoma - genetics</subject><subject>Humans</subject><subject>Laboratory Investigation</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Oncology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Rad51 Recombinase - genetics</subject><subject>Risk Factors</subject><subject>X-ray Repair Cross Complementing Protein 1</subject><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1LxDAQhoMouq7-AC9S8OKlOtMkTXJc1k9YEETBW0ibdKl0m7VpEffXm2VXEUHwEIaQZ97J8BBygnCBAOIyIEIOKSBPUQmWrnbICLmgqaCC7pIRYC5SrtjLATkM4RUAmKC4Tw6ynCMyRUfkdhKCL2vT175NCte_O9cmj5OrhGPSBZSANIPEtDYJQyjdsq-Luqn7j6T3ybypfdGY0PuFOSJ7lWmCO97WMXm-uX6a3qWzh9v76WSWlkzwPnWFk9aUlHJpqFWVsBQy45xRlbXAIN4qrmSVoVKmLKxivMycKLiwjDEr6Jicb3KXnX8bXOj1oo7_ahrTOj8EjSLnKp5M_QcFKSWV69SzX-irH7o2LhIpLkEhyjxSuKHKzofQuUovu3phug-NoNdC9EaIjkL0WohexZ7TbfJQLJz97vgyEIFsA4T41M5d92P0n6mfcn6UGg</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Franceschi, S.</creator><creator>Tomei, S.</creator><creator>Mazzanti, C. 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M.</au><au>Lessi, F.</au><au>Aretini, P.</au><au>La Ferla, M.</au><au>De Gregorio, V.</au><au>Pasqualetti, F.</au><au>Zavaglia, K.</au><au>Bevilacqua, G.</au><au>Naccarato, A. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between RAD 51 rs1801320 and susceptibility to glioblastoma</atitle><jtitle>Journal of neuro-oncology</jtitle><stitle>J Neurooncol</stitle><addtitle>J Neurooncol</addtitle><date>2016</date><risdate>2016</risdate><volume>126</volume><issue>2</issue><spage>265</spage><epage>270</epage><pages>265-270</pages><issn>0167-594X</issn><eissn>1573-7373</eissn><abstract>Glioblastoma is the most common and aggressive malignant primary brain tumor. Despite decades of research and the advent of new therapies, patients with glioblastoma continue to have a very poor prognosis. Radiation therapy has a major role as adjuvant treatment for glioblastoma following surgical resection. Many studies have shown that polymorphisms of genes involved in pathways of DNA repair may affect the sensitivity of the cells to treatment. Although the role of these polymorphisms has been investigated in relation to response to radiotherapy, their role as predisposing factors to glioblastoma has not been clarified yet. In the present study, we evaluated the association between polymorphisms in DNA repair genes, namely: XRCC1 rs25487, XRCC3 rs861539 and RAD51 rs1801320, with the susceptibility to develop glioblastoma. Eighty-five glioblastoma patients and 70 matched controls were recruited for this study. Data from the 1000 Genomes Project (98 Tuscans) were also downloaded and used for the association analysis. Subjects carrying RAD51 rs1801320 GC genotype showed an increased risk of glioblastoma (GC vs GG, χ
2
= 10.75; OR 3.0087; p = 0.0010). The C allele was also significantly associated to glioblastoma (χ
2
= 8.66; OR 2.5674; p = 0.0032). Moreover, RAD51 rs1801320 C allele increased the risk to develop glioblastoma also when combined to XRCC1 rs25487 G allele and XRCC3 rs861539 C allele (χ
2
= 6.558; p = 0.0053).</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26511493</pmid><doi>10.1007/s11060-015-1974-z</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Brain Neoplasms - genetics DNA Repair DNA-Binding Proteins - genetics Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Glioblastoma - genetics Humans Laboratory Investigation Male Medicine Medicine & Public Health Middle Aged Neurology Oncology Polymorphism, Single Nucleotide Rad51 Recombinase - genetics Risk Factors X-ray Repair Cross Complementing Protein 1 |
| title | Association between RAD 51 rs1801320 and susceptibility to glioblastoma |
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