Lack of genetic association of the TGM2 gene with schizophrenia in a Chinese population
The gene coding for transglutaminase 2 (TGM2) has been reported to be associated with schizophrenia in a White population. The present study was then designed to replicate this initial finding in a Chinese population. A total of 428 individuals with schizophrenia and 555 control participants were re...
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| Veröffentlicht in: | Psychiatric genetics 2015-12, Vol.25 (6), p.259-262 |
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| creator | Wang, Jiaxin Liu, Yang Wang, Zhenqi Du, Weili Hui, Li Zhao, Xinli Zhao, Xiaoxia Zhang, Xuan Wei, Jun |
| description | The gene coding for transglutaminase 2 (TGM2) has been reported to be associated with schizophrenia in a White population. The present study was then designed to replicate this initial finding in a Chinese population. A total of 428 individuals with schizophrenia and 555 control participants were recruited for genetic analysis. Four single nucleotide polymorphisms present in the TGM2 gene were selected for genotyping, including rs2076380, rs7270785, rs4811528, and rs6023526, by PCR-based restriction fragment length polymorphism analysis. None of these four single nucleotide polymorphisms genotyped showed an association with schizophrenia, although these 428 cases and 555 controls had 97% power to detect a disease association in small effect size (odds ratio=1.5). The present results did not support the TGM2 association with schizophrenia. It is thus possible that the TGM2 finding may have resulted from a random error of sampling. |
| doi_str_mv | 10.1097/YPG.0000000000000103 |
| format | Article |
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The present study was then designed to replicate this initial finding in a Chinese population. A total of 428 individuals with schizophrenia and 555 control participants were recruited for genetic analysis. Four single nucleotide polymorphisms present in the TGM2 gene were selected for genotyping, including rs2076380, rs7270785, rs4811528, and rs6023526, by PCR-based restriction fragment length polymorphism analysis. None of these four single nucleotide polymorphisms genotyped showed an association with schizophrenia, although these 428 cases and 555 controls had 97% power to detect a disease association in small effect size (odds ratio=1.5). The present results did not support the TGM2 association with schizophrenia. It is thus possible that the TGM2 finding may have resulted from a random error of sampling.</description><identifier>ISSN: 0955-8829</identifier><identifier>EISSN: 1473-5873</identifier><identifier>DOI: 10.1097/YPG.0000000000000103</identifier><identifier>PMID: 26307914</identifier><language>eng</language><publisher>England: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Asian Continental Ancestry Group - genetics ; Case-Control Studies ; China ; Female ; Genetic Association Studies - methods ; Genetic Predisposition to Disease ; GTP-Binding Proteins - genetics ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Schizophrenia - genetics ; Transglutaminases - genetics</subject><ispartof>Psychiatric genetics, 2015-12, Vol.25 (6), p.259-262</ispartof><rights>Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3893-d16029b5b96190e65a0de4ed245f6c49e2bfd0bdd1611b17e358696f9eeb8b573</citedby><cites>FETCH-LOGICAL-c3893-d16029b5b96190e65a0de4ed245f6c49e2bfd0bdd1611b17e358696f9eeb8b573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26307914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jiaxin</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Wang, Zhenqi</creatorcontrib><creatorcontrib>Du, Weili</creatorcontrib><creatorcontrib>Hui, Li</creatorcontrib><creatorcontrib>Zhao, Xinli</creatorcontrib><creatorcontrib>Zhao, Xiaoxia</creatorcontrib><creatorcontrib>Zhang, Xuan</creatorcontrib><creatorcontrib>Wei, Jun</creatorcontrib><title>Lack of genetic association of the TGM2 gene with schizophrenia in a Chinese population</title><title>Psychiatric genetics</title><addtitle>Psychiatr Genet</addtitle><description>The gene coding for transglutaminase 2 (TGM2) has been reported to be associated with schizophrenia in a White population. 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All rights reserved</pub><pmid>26307914</pmid><doi>10.1097/YPG.0000000000000103</doi><tpages>4</tpages></addata></record> |
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| ispartof | Psychiatric genetics, 2015-12, Vol.25 (6), p.259-262 |
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| subjects | Adult Asian Continental Ancestry Group - genetics Case-Control Studies China Female Genetic Association Studies - methods Genetic Predisposition to Disease GTP-Binding Proteins - genetics Humans Male Middle Aged Polymorphism, Single Nucleotide Schizophrenia - genetics Transglutaminases - genetics |
| title | Lack of genetic association of the TGM2 gene with schizophrenia in a Chinese population |
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