Mice null for NEDD9 (HEF1) display extensive hippocampal dendritic spine loss and cognitive impairment

Abstract NEDD9 (neural precursor cell expressed, developmentally down-regulated 9) is a member of the CAS (Crk-associated substrate) family of scaffolding proteins that regulate cell adhesion and migration. A Nedd9 knock-out/ lacZ knock-in mouse ( Nedd9 −/− ) was developed in order to study Nedd9 ex...

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Veröffentlicht in:	Brain research 2016-02, Vol.1632, p.141-155
Hauptverfasser:	Knutson, D.C, Mitzey, A.M, Talton, L.E, Clagett-Dame, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - deficiency Animals CAS Cognition Disorders - metabolism Cognition Disorders - pathology Dendritic spine density Dendritic Spines - metabolism Dendritic Spines - pathology Female Gene Knock-In Techniques Hippocampus Hippocampus - metabolism Hippocampus - pathology Male Mice Mice, Inbred C57BL Mice, Knockout NEDD9 Neurology Null mutant Retinoic acid-induced differentiation
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