Hypoxia alters steroidogenesis in female marine medaka through miRNAs regulation

•Hypoxia induces 43 miRNAs deregulation in the ovary of marine medaka.•Hypoxia-suppressed miRNAs target a variety of steroidogenic enzymes.•Hypoxia alters steroidogenic enzymes and hormone receptors through miRNA. Hypoxia is a worldwide environmental problem in marine ecosystems, leading to serious...

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Veröffentlicht in:	Aquatic toxicology 2016-03, Vol.172, p.1-8
Hauptverfasser:	Lai, Keng Po, Li, Jing-Woei, Tse, Anna Chung-Kwan, Chan, Ting-Fung, Wu, Rudolf Shiu-Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Female Fish Fish Proteins - genetics Freshwater Gene Expression Regulation - physiology Hypoxia Hypoxia - physiopathology MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Oryzias - physiology Oryzias latipes Oryzias melastigma Ovary Ovary - metabolism Reproduction - genetics Reproduction - physiology Sequence Analysis, RNA Steroidogenesis Steroids - biosynthesis
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