Phenotypic heterogeneity in study populations may significantly confound the results of genetic association studies on alcohol dependence

BACKGROUNDThe interpretation of genetic studies on alcohol dependence may be confounded by the co-occurrence of substance dependence, psychiatric disorders and alcohol-related comorbidities, for example, cirrhosis. Significant single-marker and haplotypic associations between polymorphisms in the zi...

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Veröffentlicht in:	Psychiatric genetics 2015-12, Vol.25 (6), p.234-240
Hauptverfasser:	Ali, M Adam, Way, Michael J, Marks, Michael, Guerrini, Irene, Thomson, Allan D, Strang, John, McQuillin, Andrew, Morgan, Marsha Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism - ethnology Alcoholism - genetics Alcoholism - pathology Alcoholism - psychology Carrier Proteins - genetics Case-Control Studies European Continental Ancestry Group - genetics Female Fibrosis - etiology Fibrosis - genetics Genetic Association Studies Genetic Predisposition to Disease Humans Male Phenotype Polymorphism, Single Nucleotide
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