Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials

IMPORTANCE: Identifying measures that are associated with the cytosine-adenine-guanine (CAG) expansion in individuals before diagnosis of Huntington disease (HD) has implications for designing clinical trials. OBJECTIVE: To identify the earliest features associated with the motor diagnosis of HD in...

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Veröffentlicht in:	JAMA neurology 2016-01, Vol.73 (1), p.1-9
Hauptverfasser:	Biglan, Kevin Michael, Shoulson, Ira, Kieburtz, Karl, Oakes, David, Kayson, Elise, Zhao, Hongwei, Romer, Megan, Young, Anne, Hersch, Steven, Penney, Jack, Marder, Karen, Paulsen, Jane, Quaid, Kimberly, Siemers, Eric, Tanner, Caroline, Mallonee, William, Suter, Greg, Dubinsky, Richard, Gray, Carolyn, Nance, Martha, Bundlie, Scott, Radtke, Dawn, Kostyk, Sandra, Baic, Corrine, Caress, James, Hunt, Victoria, O’Neill, Christine, Chouinard, Sylvain, Factor, Stewart, Greenamyre, Timothy, Wood-Siverio, Cathy, Corey-Bloom, Jody, Song, David, Peavy, Guerry, Moskowitz, Carol, Wesson, Melissa, Bird, Thomas, Lipe, Hillary, Blindauer, Karen, Marshall, Frederick, Zimmerman, Carol, Goldstein, Jody, Rosas, Diana, Novak, Peter, Caviness, John, Adler, Charles, Duffy, Amy, Tempkin, Teresa, Richman, David, Seeberger, Lauren, Albin, Roger, Chou, Kelvin L, Racette, Brad, Perlman, Susan, Bordelon, Yvette, Martin, Wayne, Wieler, Marguerite, Leavitt, Blair, Raymond, Lynn, Decolongon, Joji, Clarke, Lorne, Jankovic, Joseph, Hunter, Christine, Hauser, Robert A, Sanchez-Ramos, Juan, Furtado, Sarah, Suchowersky, Oksana, Klimek, Mary Lou, Guttman, Mark, Sethna, Rustom, Feigin, Andrew, Cox, Marie, Shannon, Barbara, Percy, Alan, Dure, Leon, Johnson, William, Higgins, Donald, Molho, Eric, Nickerson, Constance, Evans, Sharon, Hobson, Douglas, Singer, Carlos, Galvez-Jimenez, Nestor, Shannon, Kathleen, Comella, Cynthia, Ross, Christopher, Saint-Hilaire, Marie H, Testa, Claudia, Rosenblatt, Adam, Como, Peter, Kumar, Rajeev, Stout, Julie, Brocht, Alicia, Weaver, Christine, Foroud, Tatiana, Gusella, James, MacDonald, Marcy, Myers, Richard, Fahn, Stanley, Shults, Clifford
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cohort Studies Female Genetic Association Studies - methods Humans Huntington Disease - diagnosis Huntington Disease - genetics Longitudinal Studies Male Middle Aged Mutation - genetics Prospective Studies Randomized Controlled Trials as Topic - methods Single-Blind Method Trinucleotide Repeat Expansion - genetics
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