A safety and pharmacokinetic trial assessing delivery of dapivirine from a vaginal ring in healthy women

OBJECTIVES:Women-initiated HIV-prevention products are urgently needed. To address this need, a trial was conducted to assess the safety and pharmacokinetics of a silicone elastomer matrix vaginal ring containing 25 mg of the antiretroviral drug dapivirine when used continuously for 28 consecutive d...

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Veröffentlicht in:	AIDS (London) 2014-06, Vol.28 (10), p.1479-1487
Hauptverfasser:	Nel, Annalene, Haazen, Wouter, Nuttall, Jeremy, Romano, Joseph, Rosenberg, Zeda, van Niekerk, Neliëtte
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult AIDS/HIV Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Anti-HIV Agents - pharmacokinetics Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Body Fluids - chemistry Contraceptive Devices, Female - adverse effects Double-Blind Method Drug Delivery Systems - adverse effects Female Healthy Volunteers Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Lentivirus Medical sciences Pharmacology. Drug treatments Placebos - administration & dosage Pyrimidines - administration & dosage Pyrimidines - adverse effects Pyrimidines - pharmacokinetics Retroviridae Vagina - chemistry Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Young Adult
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