The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma

Neuroblastoma (NB) is an aggressive pediatric tumor, responsible for 15% of cancer-related deaths in childhood, lacking an effective treatment in its advanced stages. The P2X7 receptor for extracellular ATP was associated to NB cell proliferation and recently emerged as a promoter of tumor engraftme...

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Veröffentlicht in:	Oncogene 2015-10, Vol.34 (41), p.5240-5251
Hauptverfasser:	Amoroso, F, Capece, M, Rotondo, A, Cangelosi, D, Ferracin, M, Franceschini, A, Raffaghello, L, Pistoia, V, Varesio, L, Adinolfi, E
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 13/89 631/67/2332 64 64/60 82/29 82/80 96 96/1 96/95 AKT protein Angiogenesis Animals Apoptosis Cell Biology Cell Line, Tumor Cell Proliferation Cellular signal transduction Children Development and progression Female Genetic aspects Glycogen Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Health aspects Human Genetics Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Innovations Internal Medicine Medicine Medicine & Public Health Mice, Nude Molecular targeted therapy Neoplasm Transplantation Neuroblastoma Neuroblastoma - metabolism Oncology original-article Phosphatidylinositol 3-Kinases - metabolism Receptors, Purinergic P2X7 - physiology Signal Transduction Therapeutic applications Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vascularization
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