Activity-dependent regulation of calcium and ribosomes in the chick cochlear nucleus

Highlights • [Ca2+ ]i and ribosomes (Y10B-ir) show rapid changes in NM following deafferentation. • There is a dissociation between how [Ca2+ ]i and ribosomes are regulated. • Selective mGluR receptor blockade during stimulation dissociates the two events. • Blockade of group I mGluRs affects change...

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Veröffentlicht in:	Neuroscience 2016-03, Vol.316, p.201-208
Hauptverfasser:	Call, C.L, Hyson, R.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - pharmacology Analysis of Variance Animals auditory system Calcium - metabolism cell death Chick Embryo Cochlear Nucleus - drug effects Cochlear Nucleus - metabolism deafness Electric Stimulation Evoked Potentials, Auditory - physiology Excitatory Amino Acid Antagonists - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology In Vitro Techniques Indans - pharmacology metabotropic glutamate receptors Neurology Optical Imaging Ribosomes - metabolism Time Factors Xanthenes - pharmacology
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Beschreibung
Zusammenfassung:	Highlights • [Ca2+ ]i and ribosomes (Y10B-ir) show rapid changes in NM following deafferentation. • There is a dissociation between how [Ca2+ ]i and ribosomes are regulated. • Selective mGluR receptor blockade during stimulation dissociates the two events. • Blockade of group I mGluRs affects changes in both [Ca2+ ]i and ribosomes. • Blockade of group II mGluRs affects only ribosomal changes.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.12.042