Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen

Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on p...

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Veröffentlicht in:	Journal of toxicological sciences 2016/02/01, Vol.41(1), pp.123-128
Hauptverfasser:	Zaid, Younes, Marhoume, Fatimazahra, Senhaji, Nezha, Kojok, Kevin, Boufous, Hicham, Naya, Abdallah, Oudghiri, Mounia, Darif, Youssef, Habti, Norddine, Zouine, Soukaina, Mohamed, Fekhaoui, Chait, Abderahmane, Bagri, Abdellah
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Animals Collagen - pharmacology Female Humans In Vitro Techniques Male Paraphenylene diamine Phenylenediamines - toxicity Platelet Platelet Activation - drug effects Platelet Aggregation - drug effects Rats, Sprague-Dawley Thrombosis - etiology Thrombus formation Toxicity
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