Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen
Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on p...
Gespeichert in:
| Veröffentlicht in: | Journal of toxicological sciences 2016/02/01, Vol.41(1), pp.123-128 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 128 |
|---|---|
| container_issue | 1 |
| container_start_page | 123 |
| container_title | Journal of toxicological sciences |
| container_volume | 41 |
| creator | Zaid, Younes Marhoume, Fatimazahra Senhaji, Nezha Kojok, Kevin Boufous, Hicham Naya, Abdallah Oudghiri, Mounia Darif, Youssef Habti, Norddine Zouine, Soukaina Mohamed, Fekhaoui Chait, Abderahmane Bagri, Abdellah |
| description | Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on platelet function. Our findings demonstrated that platelet activation and aggregation were strongly enhanced by PPD. Treatment with PPD primed human platelets that became more reactive in response to low doses of collagen. Furthermore, PPD exacerbated thrombus formation in rats in comparison with those untreated. Our results suggest that PPD is an important platelet primer predisposing platelets to promote thrombus formation in response to vascular injury. This should prompt the authorities to consider controlling the marketing of this product. |
| doi_str_mv | 10.2131/jts.41.123 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1765948037</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3944236441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c585t-58d35282669155ac7913081838749d83b5f803fdc23aab4ed43c6245533fdf9b3</originalsourceid><addsrcrecordid>eNqNkc1rFDEchoNY7Fq9-AdIwIsIs-Z7koOHUvyCQnvQc8hkfrM7y0wyJhm0_31Tdt2DJ08veXl4SPIi9IaSLaOcfjyUvBV0Sxl_hjZUa9Jwo81ztCFc64ZySS7Ry5wPhLCWSPECXTLVKs6N2aB875Jb9hAeJgiA-9HNY0344zykzhXIeJlqTFCw2-0S7FwZY8Au9LjsU5y7NeMhpvlYjwEnyEsMGXCJ2OEp_sZ9rKc4YB-nye0gvEIXg5syvD7lFfr55fOPm2_N7d3X7zfXt42XWpZG6p5LpplShkrpfGsoJ5pqrlthes07OWjCh94z7lwnoBfcKyak5LUcTMev0Pujd0nx1wq52HnMHuolAsQ1W9oqaUR1tP-DEq04kayi7_5BD3FNoT7kiWKtUkqoSn04Uj7FnBMMdknj7NKDpcQ-rWbralZQW1er8NuTcu1m6M_o35kq8OkIHHKpP3gGXCqjn-DsOgnPvd-7ZCHwR3yDqOc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1762766646</pqid></control><display><type>article</type><title>Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Free Full-Text Journals in Chemistry</source><creator>Zaid, Younes ; Marhoume, Fatimazahra ; Senhaji, Nezha ; Kojok, Kevin ; Boufous, Hicham ; Naya, Abdallah ; Oudghiri, Mounia ; Darif, Youssef ; Habti, Norddine ; Zouine, Soukaina ; Mohamed, Fekhaoui ; Chait, Abderahmane ; Bagri, Abdellah</creator><creatorcontrib>Zaid, Younes ; Marhoume, Fatimazahra ; Senhaji, Nezha ; Kojok, Kevin ; Boufous, Hicham ; Naya, Abdallah ; Oudghiri, Mounia ; Darif, Youssef ; Habti, Norddine ; Zouine, Soukaina ; Mohamed, Fekhaoui ; Chait, Abderahmane ; Bagri, Abdellah</creatorcontrib><description>Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on platelet function. Our findings demonstrated that platelet activation and aggregation were strongly enhanced by PPD. Treatment with PPD primed human platelets that became more reactive in response to low doses of collagen. Furthermore, PPD exacerbated thrombus formation in rats in comparison with those untreated. Our results suggest that PPD is an important platelet primer predisposing platelets to promote thrombus formation in response to vascular injury. This should prompt the authorities to consider controlling the marketing of this product.</description><identifier>ISSN: 0388-1350</identifier><identifier>EISSN: 1880-3989</identifier><identifier>DOI: 10.2131/jts.41.123</identifier><identifier>PMID: 26763399</identifier><language>eng</language><publisher>Japan: The Japanese Society of Toxicology</publisher><subject>Aggregation ; Animals ; Collagen - pharmacology ; Female ; Humans ; In Vitro Techniques ; Male ; Paraphenylene diamine ; Phenylenediamines - toxicity ; Platelet ; Platelet Activation - drug effects ; Platelet Aggregation - drug effects ; Rats, Sprague-Dawley ; Thrombosis - etiology ; Thrombus formation ; Toxicity</subject><ispartof>The Journal of Toxicological Sciences, 2016/02/01, Vol.41(1), pp.123-128</ispartof><rights>2016 The Japanese Society of Toxicology</rights><rights>Copyright Japan Science and Technology Agency 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-58d35282669155ac7913081838749d83b5f803fdc23aab4ed43c6245533fdf9b3</citedby><cites>FETCH-LOGICAL-c585t-58d35282669155ac7913081838749d83b5f803fdc23aab4ed43c6245533fdf9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1879,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26763399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaid, Younes</creatorcontrib><creatorcontrib>Marhoume, Fatimazahra</creatorcontrib><creatorcontrib>Senhaji, Nezha</creatorcontrib><creatorcontrib>Kojok, Kevin</creatorcontrib><creatorcontrib>Boufous, Hicham</creatorcontrib><creatorcontrib>Naya, Abdallah</creatorcontrib><creatorcontrib>Oudghiri, Mounia</creatorcontrib><creatorcontrib>Darif, Youssef</creatorcontrib><creatorcontrib>Habti, Norddine</creatorcontrib><creatorcontrib>Zouine, Soukaina</creatorcontrib><creatorcontrib>Mohamed, Fekhaoui</creatorcontrib><creatorcontrib>Chait, Abderahmane</creatorcontrib><creatorcontrib>Bagri, Abdellah</creatorcontrib><title>Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen</title><title>Journal of toxicological sciences</title><addtitle>J Toxicol Sci</addtitle><description>Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on platelet function. Our findings demonstrated that platelet activation and aggregation were strongly enhanced by PPD. Treatment with PPD primed human platelets that became more reactive in response to low doses of collagen. Furthermore, PPD exacerbated thrombus formation in rats in comparison with those untreated. Our results suggest that PPD is an important platelet primer predisposing platelets to promote thrombus formation in response to vascular injury. This should prompt the authorities to consider controlling the marketing of this product.</description><subject>Aggregation</subject><subject>Animals</subject><subject>Collagen - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Paraphenylene diamine</subject><subject>Phenylenediamines - toxicity</subject><subject>Platelet</subject><subject>Platelet Activation - drug effects</subject><subject>Platelet Aggregation - drug effects</subject><subject>Rats, Sprague-Dawley</subject><subject>Thrombosis - etiology</subject><subject>Thrombus formation</subject><subject>Toxicity</subject><issn>0388-1350</issn><issn>1880-3989</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1rFDEchoNY7Fq9-AdIwIsIs-Z7koOHUvyCQnvQc8hkfrM7y0wyJhm0_31Tdt2DJ08veXl4SPIi9IaSLaOcfjyUvBV0Sxl_hjZUa9Jwo81ztCFc64ZySS7Ry5wPhLCWSPECXTLVKs6N2aB875Jb9hAeJgiA-9HNY0344zykzhXIeJlqTFCw2-0S7FwZY8Au9LjsU5y7NeMhpvlYjwEnyEsMGXCJ2OEp_sZ9rKc4YB-nye0gvEIXg5syvD7lFfr55fOPm2_N7d3X7zfXt42XWpZG6p5LpplShkrpfGsoJ5pqrlthes07OWjCh94z7lwnoBfcKyak5LUcTMev0Pujd0nx1wq52HnMHuolAsQ1W9oqaUR1tP-DEq04kayi7_5BD3FNoT7kiWKtUkqoSn04Uj7FnBMMdknj7NKDpcQ-rWbralZQW1er8NuTcu1m6M_o35kq8OkIHHKpP3gGXCqjn-DsOgnPvd-7ZCHwR3yDqOc</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Zaid, Younes</creator><creator>Marhoume, Fatimazahra</creator><creator>Senhaji, Nezha</creator><creator>Kojok, Kevin</creator><creator>Boufous, Hicham</creator><creator>Naya, Abdallah</creator><creator>Oudghiri, Mounia</creator><creator>Darif, Youssef</creator><creator>Habti, Norddine</creator><creator>Zouine, Soukaina</creator><creator>Mohamed, Fekhaoui</creator><creator>Chait, Abderahmane</creator><creator>Bagri, Abdellah</creator><general>The Japanese Society of Toxicology</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>20160201</creationdate><title>Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen</title><author>Zaid, Younes ; Marhoume, Fatimazahra ; Senhaji, Nezha ; Kojok, Kevin ; Boufous, Hicham ; Naya, Abdallah ; Oudghiri, Mounia ; Darif, Youssef ; Habti, Norddine ; Zouine, Soukaina ; Mohamed, Fekhaoui ; Chait, Abderahmane ; Bagri, Abdellah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-58d35282669155ac7913081838749d83b5f803fdc23aab4ed43c6245533fdf9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aggregation</topic><topic>Animals</topic><topic>Collagen - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Paraphenylene diamine</topic><topic>Phenylenediamines - toxicity</topic><topic>Platelet</topic><topic>Platelet Activation - drug effects</topic><topic>Platelet Aggregation - drug effects</topic><topic>Rats, Sprague-Dawley</topic><topic>Thrombosis - etiology</topic><topic>Thrombus formation</topic><topic>Toxicity</topic><toplevel>online_resources</toplevel><creatorcontrib>Zaid, Younes</creatorcontrib><creatorcontrib>Marhoume, Fatimazahra</creatorcontrib><creatorcontrib>Senhaji, Nezha</creatorcontrib><creatorcontrib>Kojok, Kevin</creatorcontrib><creatorcontrib>Boufous, Hicham</creatorcontrib><creatorcontrib>Naya, Abdallah</creatorcontrib><creatorcontrib>Oudghiri, Mounia</creatorcontrib><creatorcontrib>Darif, Youssef</creatorcontrib><creatorcontrib>Habti, Norddine</creatorcontrib><creatorcontrib>Zouine, Soukaina</creatorcontrib><creatorcontrib>Mohamed, Fekhaoui</creatorcontrib><creatorcontrib>Chait, Abderahmane</creatorcontrib><creatorcontrib>Bagri, Abdellah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of toxicological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zaid, Younes</au><au>Marhoume, Fatimazahra</au><au>Senhaji, Nezha</au><au>Kojok, Kevin</au><au>Boufous, Hicham</au><au>Naya, Abdallah</au><au>Oudghiri, Mounia</au><au>Darif, Youssef</au><au>Habti, Norddine</au><au>Zouine, Soukaina</au><au>Mohamed, Fekhaoui</au><au>Chait, Abderahmane</au><au>Bagri, Abdellah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen</atitle><jtitle>Journal of toxicological sciences</jtitle><addtitle>J Toxicol Sci</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>41</volume><issue>1</issue><spage>123</spage><epage>128</epage><pages>123-128</pages><issn>0388-1350</issn><eissn>1880-3989</eissn><abstract>Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests. As platelets play a key role in cardiovascular diseases, we aimed to determine the impact of PPD in vitro and in vivo on platelet function. Our findings demonstrated that platelet activation and aggregation were strongly enhanced by PPD. Treatment with PPD primed human platelets that became more reactive in response to low doses of collagen. Furthermore, PPD exacerbated thrombus formation in rats in comparison with those untreated. Our results suggest that PPD is an important platelet primer predisposing platelets to promote thrombus formation in response to vascular injury. This should prompt the authorities to consider controlling the marketing of this product.</abstract><cop>Japan</cop><pub>The Japanese Society of Toxicology</pub><pmid>26763399</pmid><doi>10.2131/jts.41.123</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0388-1350 |
| ispartof | The Journal of Toxicological Sciences, 2016/02/01, Vol.41(1), pp.123-128 |
| issn | 0388-1350 1880-3989 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1765948037 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | Aggregation Animals Collagen - pharmacology Female Humans In Vitro Techniques Male Paraphenylene diamine Phenylenediamines - toxicity Platelet Platelet Activation - drug effects Platelet Aggregation - drug effects Rats, Sprague-Dawley Thrombosis - etiology Thrombus formation Toxicity |
| title | Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T19%3A23%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Paraphenylene%20diamine%20exacerbates%20platelet%20aggregation%20and%20thrombus%20formation%20in%20response%20to%20a%20low%20dose%20of%20collagen&rft.jtitle=Journal%20of%20toxicological%20sciences&rft.au=Zaid,%20Younes&rft.date=2016-02-01&rft.volume=41&rft.issue=1&rft.spage=123&rft.epage=128&rft.pages=123-128&rft.issn=0388-1350&rft.eissn=1880-3989&rft_id=info:doi/10.2131/jts.41.123&rft_dat=%3Cproquest_cross%3E3944236441%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1762766646&rft_id=info:pmid/26763399&rfr_iscdi=true |