Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease

Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease

We are currently investigating colonic biopsies from patients with Parkinson disease (PD) and healthy controls (HC) participating in the Discovery study.1 Our findings partially agree with those of Visanji etal.2 Specifically, we found that immunohistochemistry using antibodies for nonphosphorylated...

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Veröffentlicht in:Neurology 2015-09, Vol.85 (9), p.834-835
Hauptverfasser: Ruffmann, Claudio, Parkkinen, Laura
Format: Artikel
Sprache:eng
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alpha-Synuclein - metabolism
Biopsy
Colon - metabolism
Female
Humans
Intestinal Mucosa - metabolism
Male
Parkinson Disease - diagnosis
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container_title Neurology
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creator Ruffmann, Claudio
Parkkinen, Laura
description We are currently investigating colonic biopsies from patients with Parkinson disease (PD) and healthy controls (HC) participating in the Discovery study.1 Our findings partially agree with those of Visanji etal.2 Specifically, we found that immunohistochemistry using antibodies for nonphosphorylated but also phosphorylated forms of alpha -synuclein does not allow accurate and reliable distinction between PD and HC groups.
doi_str_mv 10.1212/WNL.0000000000001904
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source MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete
subjects alpha-Synuclein - metabolism
Biopsy
Colon - metabolism
Female
Humans
Intestinal Mucosa - metabolism
Male
Parkinson Disease - diagnosis
title Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease
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