Malignant Transformation in Von-Meyenburg Complexes: Histologic and Immunohistochemical Clues With Illustrative Cases
Benign developmental defects known as Von-Meyenburg complexes (VMCs) have been postulated to progress to cholangiocarcinoma (CC) in rare instances. Although a gradual, sequential histologic transition from VMCs to CC has been described in some of these cases, the underlying genetic mechanism is yet...
Gespeichert in:
| Veröffentlicht in: | Applied immunohistochemistry & molecular morphology 2015-10, Vol.23 (9), p.607-614 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 614 |
|---|---|
| container_issue | 9 |
| container_start_page | 607 |
| container_title | Applied immunohistochemistry & molecular morphology |
| container_volume | 23 |
| creator | Parekh, Vishwas Peker, Deniz |
| description | Benign developmental defects known as Von-Meyenburg complexes (VMCs) have been postulated to progress to cholangiocarcinoma (CC) in rare instances. Although a gradual, sequential histologic transition from VMCs to CC has been described in some of these cases, the underlying genetic mechanism is yet to be elucidated. Here, we review the literature to put together a report on the clinicopathologic features and immunohistochemical changes associated with such transformation. We also review the documented association between CC and p16 inactivation, and discuss a possible role for this mechanism to contribute in VMCs to CC progression. In addition, using 2 illustrative cases encountered at our institute, we provide morphologic and immunohistochemical clues that can be used to detect such progression from hamartoma to malignancy. These cases and the accompanying review of literature further solidify the association between VMCs and CC. |
| doi_str_mv | 10.1097/PAI.0000000000000132 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1765942110</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1765942110</sourcerecordid><originalsourceid>FETCH-LOGICAL-c289t-8b8b97af6a80084e3787c0561f73d4537a1be52f6a488a3dc6383e143306cb1a3</originalsourceid><addsrcrecordid>eNqNkU1PwzAMhiMEYmPwDxDKkUtHvtqm3KYKWKVNcBhwrNIs3YLSZCQtYv-eThsIccIXW_bj15ZeAC4xGmOUpTdPk2KMfgem5AgMcUxpxFDMj3c1wxFBOBmAsxDeECKEMnYKBiROedaDQ9DNhdErK2wLF17YUDvfiFY7C7WFL85Gc7VVtur8Cuau2Rj1qcItnOrQOuNWWkJhl7Boms669a4p16rRUhiYm04F-KrbNSyM6ULre9kPBXMRVDgHJ7UwQV0c8gg8398t8mk0e3wo8skskoRnbcQrXmWpqBPBEeJM0ZSnEsUJrlO6ZDFNBa5UTPo541zQpUwopwozSlEiKyzoCFzvdTfevff_tGWjg1TGCKtcF0qcJnHGCMboHyjBlPGMxj3K9qj0LgSv6nLjdSP8tsSo3HlT9t6Uf73p164OF7qqUcufpW8z6BdKDIp4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1721348935</pqid></control><display><type>article</type><title>Malignant Transformation in Von-Meyenburg Complexes: Histologic and Immunohistochemical Clues With Illustrative Cases</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Parekh, Vishwas ; Peker, Deniz</creator><creatorcontrib>Parekh, Vishwas ; Peker, Deniz</creatorcontrib><description>Benign developmental defects known as Von-Meyenburg complexes (VMCs) have been postulated to progress to cholangiocarcinoma (CC) in rare instances. Although a gradual, sequential histologic transition from VMCs to CC has been described in some of these cases, the underlying genetic mechanism is yet to be elucidated. Here, we review the literature to put together a report on the clinicopathologic features and immunohistochemical changes associated with such transformation. We also review the documented association between CC and p16 inactivation, and discuss a possible role for this mechanism to contribute in VMCs to CC progression. In addition, using 2 illustrative cases encountered at our institute, we provide morphologic and immunohistochemical clues that can be used to detect such progression from hamartoma to malignancy. These cases and the accompanying review of literature further solidify the association between VMCs and CC.</description><identifier>ISSN: 1541-2016</identifier><identifier>EISSN: 1533-4058</identifier><identifier>DOI: 10.1097/PAI.0000000000000132</identifier><identifier>PMID: 25789533</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bile Duct Neoplasms - diagnosis ; Bile Duct Neoplasms - genetics ; Bile Duct Neoplasms - metabolism ; Bile Duct Neoplasms - pathology ; Bile Ducts, Intrahepatic - metabolism ; Bile Ducts, Intrahepatic - pathology ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - metabolism ; Cell Transformation, Neoplastic - pathology ; Cholangiocarcinoma - diagnosis ; Cholangiocarcinoma - genetics ; Cholangiocarcinoma - metabolism ; Cholangiocarcinoma - pathology ; Cyclin-Dependent Kinase Inhibitor p16 - genetics ; Cyclin-Dependent Kinase Inhibitor p16 - metabolism ; Diagnosis, Differential ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Hamartoma - diagnosis ; Hamartoma - genetics ; Hamartoma - metabolism ; Hamartoma - pathology ; Humans ; Immunohistochemistry ; Male ; Middle Aged</subject><ispartof>Applied immunohistochemistry & molecular morphology, 2015-10, Vol.23 (9), p.607-614</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c289t-8b8b97af6a80084e3787c0561f73d4537a1be52f6a488a3dc6383e143306cb1a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25789533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parekh, Vishwas</creatorcontrib><creatorcontrib>Peker, Deniz</creatorcontrib><title>Malignant Transformation in Von-Meyenburg Complexes: Histologic and Immunohistochemical Clues With Illustrative Cases</title><title>Applied immunohistochemistry & molecular morphology</title><addtitle>Appl Immunohistochem Mol Morphol</addtitle><description>Benign developmental defects known as Von-Meyenburg complexes (VMCs) have been postulated to progress to cholangiocarcinoma (CC) in rare instances. Although a gradual, sequential histologic transition from VMCs to CC has been described in some of these cases, the underlying genetic mechanism is yet to be elucidated. Here, we review the literature to put together a report on the clinicopathologic features and immunohistochemical changes associated with such transformation. We also review the documented association between CC and p16 inactivation, and discuss a possible role for this mechanism to contribute in VMCs to CC progression. In addition, using 2 illustrative cases encountered at our institute, we provide morphologic and immunohistochemical clues that can be used to detect such progression from hamartoma to malignancy. These cases and the accompanying review of literature further solidify the association between VMCs and CC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bile Duct Neoplasms - diagnosis</subject><subject>Bile Duct Neoplasms - genetics</subject><subject>Bile Duct Neoplasms - metabolism</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Ducts, Intrahepatic - metabolism</subject><subject>Bile Ducts, Intrahepatic - pathology</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Cholangiocarcinoma - diagnosis</subject><subject>Cholangiocarcinoma - genetics</subject><subject>Cholangiocarcinoma - metabolism</subject><subject>Cholangiocarcinoma - pathology</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - genetics</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - metabolism</subject><subject>Diagnosis, Differential</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hamartoma - diagnosis</subject><subject>Hamartoma - genetics</subject><subject>Hamartoma - metabolism</subject><subject>Hamartoma - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><issn>1541-2016</issn><issn>1533-4058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1PwzAMhiMEYmPwDxDKkUtHvtqm3KYKWKVNcBhwrNIs3YLSZCQtYv-eThsIccIXW_bj15ZeAC4xGmOUpTdPk2KMfgem5AgMcUxpxFDMj3c1wxFBOBmAsxDeECKEMnYKBiROedaDQ9DNhdErK2wLF17YUDvfiFY7C7WFL85Gc7VVtur8Cuau2Rj1qcItnOrQOuNWWkJhl7Boms669a4p16rRUhiYm04F-KrbNSyM6ULre9kPBXMRVDgHJ7UwQV0c8gg8398t8mk0e3wo8skskoRnbcQrXmWpqBPBEeJM0ZSnEsUJrlO6ZDFNBa5UTPo541zQpUwopwozSlEiKyzoCFzvdTfevff_tGWjg1TGCKtcF0qcJnHGCMboHyjBlPGMxj3K9qj0LgSv6nLjdSP8tsSo3HlT9t6Uf73p164OF7qqUcufpW8z6BdKDIp4</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Parekh, Vishwas</creator><creator>Peker, Deniz</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20151001</creationdate><title>Malignant Transformation in Von-Meyenburg Complexes: Histologic and Immunohistochemical Clues With Illustrative Cases</title><author>Parekh, Vishwas ; Peker, Deniz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-8b8b97af6a80084e3787c0561f73d4537a1be52f6a488a3dc6383e143306cb1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bile Duct Neoplasms - diagnosis</topic><topic>Bile Duct Neoplasms - genetics</topic><topic>Bile Duct Neoplasms - metabolism</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile Ducts, Intrahepatic - metabolism</topic><topic>Bile Ducts, Intrahepatic - pathology</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Cholangiocarcinoma - diagnosis</topic><topic>Cholangiocarcinoma - genetics</topic><topic>Cholangiocarcinoma - metabolism</topic><topic>Cholangiocarcinoma - pathology</topic><topic>Cyclin-Dependent Kinase Inhibitor p16 - genetics</topic><topic>Cyclin-Dependent Kinase Inhibitor p16 - metabolism</topic><topic>Diagnosis, Differential</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hamartoma - diagnosis</topic><topic>Hamartoma - genetics</topic><topic>Hamartoma - metabolism</topic><topic>Hamartoma - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parekh, Vishwas</creatorcontrib><creatorcontrib>Peker, Deniz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Applied immunohistochemistry & molecular morphology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parekh, Vishwas</au><au>Peker, Deniz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant Transformation in Von-Meyenburg Complexes: Histologic and Immunohistochemical Clues With Illustrative Cases</atitle><jtitle>Applied immunohistochemistry & molecular morphology</jtitle><addtitle>Appl Immunohistochem Mol Morphol</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>23</volume><issue>9</issue><spage>607</spage><epage>614</epage><pages>607-614</pages><issn>1541-2016</issn><eissn>1533-4058</eissn><abstract>Benign developmental defects known as Von-Meyenburg complexes (VMCs) have been postulated to progress to cholangiocarcinoma (CC) in rare instances. Although a gradual, sequential histologic transition from VMCs to CC has been described in some of these cases, the underlying genetic mechanism is yet to be elucidated. Here, we review the literature to put together a report on the clinicopathologic features and immunohistochemical changes associated with such transformation. We also review the documented association between CC and p16 inactivation, and discuss a possible role for this mechanism to contribute in VMCs to CC progression. In addition, using 2 illustrative cases encountered at our institute, we provide morphologic and immunohistochemical clues that can be used to detect such progression from hamartoma to malignancy. These cases and the accompanying review of literature further solidify the association between VMCs and CC.</abstract><cop>United States</cop><pmid>25789533</pmid><doi>10.1097/PAI.0000000000000132</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1541-2016 |
| ispartof | Applied immunohistochemistry & molecular morphology, 2015-10, Vol.23 (9), p.607-614 |
| issn | 1541-2016 1533-4058 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1765942110 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Aged, 80 and over Bile Duct Neoplasms - diagnosis Bile Duct Neoplasms - genetics Bile Duct Neoplasms - metabolism Bile Duct Neoplasms - pathology Bile Ducts, Intrahepatic - metabolism Bile Ducts, Intrahepatic - pathology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cholangiocarcinoma - diagnosis Cholangiocarcinoma - genetics Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Diagnosis, Differential Disease Progression Female Gene Expression Regulation, Neoplastic Hamartoma - diagnosis Hamartoma - genetics Hamartoma - metabolism Hamartoma - pathology Humans Immunohistochemistry Male Middle Aged |
| title | Malignant Transformation in Von-Meyenburg Complexes: Histologic and Immunohistochemical Clues With Illustrative Cases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T14%3A03%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Malignant%20Transformation%20in%20Von-Meyenburg%20Complexes:%20Histologic%20and%20Immunohistochemical%20Clues%20With%20Illustrative%20Cases&rft.jtitle=Applied%20immunohistochemistry%20&%20molecular%20morphology&rft.au=Parekh,%20Vishwas&rft.date=2015-10-01&rft.volume=23&rft.issue=9&rft.spage=607&rft.epage=614&rft.pages=607-614&rft.issn=1541-2016&rft.eissn=1533-4058&rft_id=info:doi/10.1097/PAI.0000000000000132&rft_dat=%3Cproquest_cross%3E1765942110%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1721348935&rft_id=info:pmid/25789533&rfr_iscdi=true |