Clinicopathologic features and prognostic indicators in Chinese patients with myelofibrosis

Objective: To define the clinicopathologic features, outcome, and prognostic indicators of myelofibrosis (MF) in Asian patients. Methods: Two hundred and seventy consecutive Chinese patients (primary MF, n = 207; post-polycythemia vera MF, n = 27; and post-essential thrombocythemia MF, n = 36) from...

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Veröffentlicht in:	Hematology (Luxembourg) 2016-01, Vol.21 (1), p.10-18
Hauptverfasser:	Gill, Harinder, Leung, Anskar Y. H., Chan, Chi-Chung, Lau, June S. M., Chan, Candia, Yip, Sze-Fai, Liu, Herman, Kho, Bonnie, Mak, Vivien, Lee, Harold K. K., Lin, Shek-Ying, Lau, Chi-Kuen, Kwong, Yok-Lam
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents - therapeutic use Asian Continental Ancestry Group Bone Marrow - drug effects Bone Marrow - pathology China Chinese Essential thrombocythemia Female Follow-Up Studies Hematopoietic Stem Cell Transplantation Humans Male Middle Aged Multivariate Analysis Myelofibrosis Platelet Count Polycythemia vera Polycythemia Vera - complications Polycythemia Vera - drug therapy Polycythemia Vera - mortality Polycythemia Vera - pathology Primary Myelofibrosis - drug therapy Primary Myelofibrosis - etiology Primary Myelofibrosis - mortality Primary Myelofibrosis - pathology Prognosis Survival Analysis Thrombocythemia, Essential - drug therapy Thrombocythemia, Essential - etiology Thrombocythemia, Essential - mortality Thrombocythemia, Essential - pathology Transplantation, Homologous Treatment Outcome
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Zusammenfassung:	Objective: To define the clinicopathologic features, outcome, and prognostic indicators of myelofibrosis (MF) in Asian patients. Methods: Two hundred and seventy consecutive Chinese patients (primary MF, n = 207; post-polycythemia vera MF, n = 27; and post-essential thrombocythemia MF, n = 36) from seven regional referral hospitals were analyzed. Results: The median overall survival (OS) for primary MF was 66 months. Multivariate analysis showed that age >65 years (P = 0.02), platelet count
ISSN:	1607-8454 1607-8454
DOI:	10.1179/1607845415Y.0000000045