Cholesteryl palmitate crystals in bronchoalveolar lavage fluid smears as a possible prognostic biomarker for chronic interstitial pneumonia: A preliminary study
Abstract Background We observed cholesterol-like crystals (Crystal X) in the bronchoalveolar lavage fluid (BALF) smears of patients with diffuse pulmonary disease. We analyzed the clinical data of patients with and without crystals, and elucidated the structure of Crystal X and its concentration in...
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| Veröffentlicht in: | Respiratory investigation 2016-03, Vol.54 (2), p.109-115 |
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| creator | Fukuhara, Naoko Tachihara, Motoko Tanino, Yoshinori Saito, Junpei Sato, Suguru Nikaido, Takefumi Misa, Kenichi Fukuhara, Atsuro Wang, Xintao Ishida, Takashi Onami, Tetsuo Munakata, Mitsuru |
| description | Abstract Background We observed cholesterol-like crystals (Crystal X) in the bronchoalveolar lavage fluid (BALF) smears of patients with diffuse pulmonary disease. We analyzed the clinical data of patients with and without crystals, and elucidated the structure of Crystal X and its concentration in the BALF. Methods Two hundred eighty-nine patients with diffuse pulmonary disease who underwent bronchoalveolar lavage (BAL) were analyzed. The relationships between the presence and number of Crystal X in BALF smears and clinical parameters were investigated. Furthermore, structure determination and quantitative analyses of the crystals were performed. Results Seventy-five (26.0%) patients had Crystal X in their BALF. The crystals were frequently observed in patients with chronic interstitial pneumonia (CIP, 60/160=35.3%). Patients with Crystal X exhibited significantly higher serum Kerbs von Lungren 6 antigen and surfactant protein-D levels ( P |
| doi_str_mv | 10.1016/j.resinv.2015.09.003 |
| format | Article |
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We analyzed the clinical data of patients with and without crystals, and elucidated the structure of Crystal X and its concentration in the BALF. Methods Two hundred eighty-nine patients with diffuse pulmonary disease who underwent bronchoalveolar lavage (BAL) were analyzed. The relationships between the presence and number of Crystal X in BALF smears and clinical parameters were investigated. Furthermore, structure determination and quantitative analyses of the crystals were performed. Results Seventy-five (26.0%) patients had Crystal X in their BALF. The crystals were frequently observed in patients with chronic interstitial pneumonia (CIP, 60/160=35.3%). Patients with Crystal X exhibited significantly higher serum Kerbs von Lungren 6 antigen and surfactant protein-D levels ( P <0.01) and lower percentage vital capacity ( P <0.05) than patients without Crystal X. The number of crystals was significantly correlated with these parameters. The presence of crystals was also associated with a lower survival rate at 1 year after the BAL. The interfacial angles of the crystals were 126±2° and 144±2°, different from those of cholesterol monohydrate crystals. Infrared absorption spectrometry showed Crystal X was cholesteryl palmitate. Its concentration was significantly higher in BALF with crystals than in BALF without crystals ( P <0.01). Conclusions Crystal X in the BALF of patients with diffuse pulmonary disease was identified as cholesteryl palmitate, which may be a useful prognostic biomarker for CIP.</description><identifier>ISSN: 2212-5345</identifier><identifier>EISSN: 2212-5353</identifier><identifier>DOI: 10.1016/j.resinv.2015.09.003</identifier><identifier>PMID: 26879480</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Biomarkers - analysis ; Bronchoalveolar lavage ; Bronchoalveolar Lavage Fluid - chemistry ; Cholesterol Esters - analysis ; Cholesteryl palmitate ; Chronic Disease ; Crystal ; Crystallization ; Humans ; Internal Medicine ; Interstitial pneumonia ; Lung Diseases, Interstitial - diagnosis ; Prognosis ; Pulmonary/Respiratory ; Retrospective Studies ; Spectrum Analysis ; Surfactant</subject><ispartof>Respiratory investigation, 2016-03, Vol.54 (2), p.109-115</ispartof><rights>The Japanese Respiratory Society</rights><rights>2015 The Japanese Respiratory Society</rights><rights>Copyright © 2015 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c572t-86b6dbd16661a7a6ce2b8fee59beb60310f4b4542e20c5b69a490a4cda29a0b33</cites><orcidid>0000-0003-2384-601X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26879480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukuhara, Naoko</creatorcontrib><creatorcontrib>Tachihara, Motoko</creatorcontrib><creatorcontrib>Tanino, Yoshinori</creatorcontrib><creatorcontrib>Saito, Junpei</creatorcontrib><creatorcontrib>Sato, Suguru</creatorcontrib><creatorcontrib>Nikaido, Takefumi</creatorcontrib><creatorcontrib>Misa, Kenichi</creatorcontrib><creatorcontrib>Fukuhara, Atsuro</creatorcontrib><creatorcontrib>Wang, Xintao</creatorcontrib><creatorcontrib>Ishida, Takashi</creatorcontrib><creatorcontrib>Onami, Tetsuo</creatorcontrib><creatorcontrib>Munakata, Mitsuru</creatorcontrib><title>Cholesteryl palmitate crystals in bronchoalveolar lavage fluid smears as a possible prognostic biomarker for chronic interstitial pneumonia: A preliminary study</title><title>Respiratory investigation</title><addtitle>Respir Investig</addtitle><description>Abstract Background We observed cholesterol-like crystals (Crystal X) in the bronchoalveolar lavage fluid (BALF) smears of patients with diffuse pulmonary disease. We analyzed the clinical data of patients with and without crystals, and elucidated the structure of Crystal X and its concentration in the BALF. Methods Two hundred eighty-nine patients with diffuse pulmonary disease who underwent bronchoalveolar lavage (BAL) were analyzed. The relationships between the presence and number of Crystal X in BALF smears and clinical parameters were investigated. Furthermore, structure determination and quantitative analyses of the crystals were performed. Results Seventy-five (26.0%) patients had Crystal X in their BALF. The crystals were frequently observed in patients with chronic interstitial pneumonia (CIP, 60/160=35.3%). Patients with Crystal X exhibited significantly higher serum Kerbs von Lungren 6 antigen and surfactant protein-D levels ( P <0.01) and lower percentage vital capacity ( P <0.05) than patients without Crystal X. The number of crystals was significantly correlated with these parameters. The presence of crystals was also associated with a lower survival rate at 1 year after the BAL. The interfacial angles of the crystals were 126±2° and 144±2°, different from those of cholesterol monohydrate crystals. Infrared absorption spectrometry showed Crystal X was cholesteryl palmitate. Its concentration was significantly higher in BALF with crystals than in BALF without crystals ( P <0.01). Conclusions Crystal X in the BALF of patients with diffuse pulmonary disease was identified as cholesteryl palmitate, which may be a useful prognostic biomarker for CIP.</description><subject>Biomarkers - analysis</subject><subject>Bronchoalveolar lavage</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Cholesterol Esters - analysis</subject><subject>Cholesteryl palmitate</subject><subject>Chronic Disease</subject><subject>Crystal</subject><subject>Crystallization</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Interstitial pneumonia</subject><subject>Lung Diseases, Interstitial - diagnosis</subject><subject>Prognosis</subject><subject>Pulmonary/Respiratory</subject><subject>Retrospective Studies</subject><subject>Spectrum Analysis</subject><subject>Surfactant</subject><issn>2212-5345</issn><issn>2212-5353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1r3DAQNaWlCWn-QSk69rKuJFvadQ-FsPQjEOih7VmM5HFWG1naSvaC_01-amfZNIdeKgQaRm_mzcybqnoreC240B_2dcbi47GWXKiadzXnzYvqUkohV6pRzctnu1UX1XUpe05HK9kK_bq6kHqz7toNv6wet7sUsEyYl8AOEEY_wYTM5aVMEArzkdmcotslCEdMATILcIR7ZEOYfc_KiJALA7rskErxNiA75HQfU5m8Y9anEfIDZjakzNyOcpHXRyKk_8kDsUacR3LDR3ZDoRj86CPkhZVp7pc31auBCsHrp_eq-vXl88_tt9Xd96-325u7lVNrOa022ure9kJrLWAN2qG0mwFRdRat5o3gQ2tb1UqU3CmrO2g7Dq3rQXbAbdNcVe_Pean43zNNxIy-OAwBIqa5GLHWqhPrTgiCtmeoy9RxxsEcsqcuFyO4Oclj9uYsjznJY3hnSB4Ke_fEMNsR--egv2IQ4NMZgNTn0WM2xXmMDnuf0U2mT_5_DP8mcMHTvCE84IJln-YcaYZGmCINNz9OK3LaEKE4F0K2zR-GIrzj</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Fukuhara, Naoko</creator><creator>Tachihara, Motoko</creator><creator>Tanino, Yoshinori</creator><creator>Saito, Junpei</creator><creator>Sato, Suguru</creator><creator>Nikaido, Takefumi</creator><creator>Misa, Kenichi</creator><creator>Fukuhara, Atsuro</creator><creator>Wang, Xintao</creator><creator>Ishida, Takashi</creator><creator>Onami, Tetsuo</creator><creator>Munakata, Mitsuru</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2384-601X</orcidid></search><sort><creationdate>20160301</creationdate><title>Cholesteryl palmitate crystals in bronchoalveolar lavage fluid smears as a possible prognostic biomarker for chronic interstitial pneumonia: A preliminary study</title><author>Fukuhara, Naoko ; Tachihara, Motoko ; Tanino, Yoshinori ; Saito, Junpei ; Sato, Suguru ; Nikaido, Takefumi ; Misa, Kenichi ; Fukuhara, Atsuro ; Wang, Xintao ; Ishida, Takashi ; Onami, Tetsuo ; Munakata, Mitsuru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-86b6dbd16661a7a6ce2b8fee59beb60310f4b4542e20c5b69a490a4cda29a0b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biomarkers - analysis</topic><topic>Bronchoalveolar lavage</topic><topic>Bronchoalveolar Lavage Fluid - chemistry</topic><topic>Cholesterol Esters - analysis</topic><topic>Cholesteryl palmitate</topic><topic>Chronic Disease</topic><topic>Crystal</topic><topic>Crystallization</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Interstitial pneumonia</topic><topic>Lung Diseases, Interstitial - diagnosis</topic><topic>Prognosis</topic><topic>Pulmonary/Respiratory</topic><topic>Retrospective Studies</topic><topic>Spectrum Analysis</topic><topic>Surfactant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukuhara, Naoko</creatorcontrib><creatorcontrib>Tachihara, Motoko</creatorcontrib><creatorcontrib>Tanino, Yoshinori</creatorcontrib><creatorcontrib>Saito, Junpei</creatorcontrib><creatorcontrib>Sato, Suguru</creatorcontrib><creatorcontrib>Nikaido, Takefumi</creatorcontrib><creatorcontrib>Misa, Kenichi</creatorcontrib><creatorcontrib>Fukuhara, Atsuro</creatorcontrib><creatorcontrib>Wang, Xintao</creatorcontrib><creatorcontrib>Ishida, Takashi</creatorcontrib><creatorcontrib>Onami, Tetsuo</creatorcontrib><creatorcontrib>Munakata, Mitsuru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukuhara, Naoko</au><au>Tachihara, Motoko</au><au>Tanino, Yoshinori</au><au>Saito, Junpei</au><au>Sato, Suguru</au><au>Nikaido, Takefumi</au><au>Misa, Kenichi</au><au>Fukuhara, Atsuro</au><au>Wang, Xintao</au><au>Ishida, Takashi</au><au>Onami, Tetsuo</au><au>Munakata, Mitsuru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholesteryl palmitate crystals in bronchoalveolar lavage fluid smears as a possible prognostic biomarker for chronic interstitial pneumonia: A preliminary study</atitle><jtitle>Respiratory investigation</jtitle><addtitle>Respir Investig</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>54</volume><issue>2</issue><spage>109</spage><epage>115</epage><pages>109-115</pages><issn>2212-5345</issn><eissn>2212-5353</eissn><abstract>Abstract Background We observed cholesterol-like crystals (Crystal X) in the bronchoalveolar lavage fluid (BALF) smears of patients with diffuse pulmonary disease. We analyzed the clinical data of patients with and without crystals, and elucidated the structure of Crystal X and its concentration in the BALF. Methods Two hundred eighty-nine patients with diffuse pulmonary disease who underwent bronchoalveolar lavage (BAL) were analyzed. The relationships between the presence and number of Crystal X in BALF smears and clinical parameters were investigated. Furthermore, structure determination and quantitative analyses of the crystals were performed. Results Seventy-five (26.0%) patients had Crystal X in their BALF. The crystals were frequently observed in patients with chronic interstitial pneumonia (CIP, 60/160=35.3%). Patients with Crystal X exhibited significantly higher serum Kerbs von Lungren 6 antigen and surfactant protein-D levels ( P <0.01) and lower percentage vital capacity ( P <0.05) than patients without Crystal X. The number of crystals was significantly correlated with these parameters. The presence of crystals was also associated with a lower survival rate at 1 year after the BAL. The interfacial angles of the crystals were 126±2° and 144±2°, different from those of cholesterol monohydrate crystals. Infrared absorption spectrometry showed Crystal X was cholesteryl palmitate. Its concentration was significantly higher in BALF with crystals than in BALF without crystals ( P <0.01). Conclusions Crystal X in the BALF of patients with diffuse pulmonary disease was identified as cholesteryl palmitate, which may be a useful prognostic biomarker for CIP.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26879480</pmid><doi>10.1016/j.resinv.2015.09.003</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2384-601X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers - analysis Bronchoalveolar lavage Bronchoalveolar Lavage Fluid - chemistry Cholesterol Esters - analysis Cholesteryl palmitate Chronic Disease Crystal Crystallization Humans Internal Medicine Interstitial pneumonia Lung Diseases, Interstitial - diagnosis Prognosis Pulmonary/Respiratory Retrospective Studies Spectrum Analysis Surfactant |
| title | Cholesteryl palmitate crystals in bronchoalveolar lavage fluid smears as a possible prognostic biomarker for chronic interstitial pneumonia: A preliminary study |
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