In vivo generation of pathogen-specific Th1 cells in the absence of the IFN-gamma receptor

The precise mechanisms that govern the commitment of CD4 T cells to become Th1 or Th2 cells in vivo are incompletely understood. Recent experiments demonstrate colocalization of the IFN-gammaR chains with the TCR during activation of naive CD4 T cells, suggesting that association of these molecules...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-09, Vol.175 (5), p.3117-3122
Hauptverfasser:	Haring, Jodie S, Badovinac, Vladimir P, Olson, Matthew R, Varga, Steven M, Harty, John T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Toxins - immunology Heat-Shock Proteins - immunology Hemolysin Proteins Interferon gamma Receptor Interferon-gamma - physiology Mice Mice, Inbred C57BL Peptide Fragments - immunology Receptors, Interferon - physiology Th1 Cells - physiology
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