The Immune Modulator FTY720 Inhibits Sphingosine-1-phosphate Lyase Activity

FTY720 is a novel immunomodulatory agent that inhibits lymphocyte trafficking and prevents allograft rejection. FTY720 is phosphorylated in vivo, and the phosphorylated drug acts as agonist for a family of G protein-coupled receptors that recognize sphingosine 1-phosphate. Evidence suggests that FTY...

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Veröffentlicht in:	The Journal of biological chemistry 2005-10, Vol.280 (40), p.33697-33700
Hauptverfasser:	Bandhuvula, Padmavathi, Tam, Yuen Yee, Oskouian, Babak, Saba, Julie D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde-Lyases - antagonists & inhibitors Aldehyde-Lyases - metabolism Animals Fingolimod Hydrochloride Gene Expression Regulation - drug effects Immunosuppressive Agents - pharmacology Lymphocytes - drug effects Lysophospholipids - analysis Lysophospholipids - metabolism Mice Propylene Glycols - pharmacology Sphingosine - analogs & derivatives Sphingosine - analysis Sphingosine - metabolism Tissue Distribution
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