Galactose conjugated platinum(II) complex targeting the Warburg effect for treatment of non-small cell lung cancer and colon cancer

Malignant neoplasms exhibit a higher rate of glycolysis than normal cells; this is known as the Warburg effect. To target it, a galactose-conjugated (trans-R,R-cyclohexane-1,2-diamine)-2-chloromalonato-platinum(II) complex (Gal-Pt) was designed, synthesized, and evaluated in five human cancer cell l...

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Veröffentlicht in:	European journal of medicinal chemistry 2016-03, Vol.110, p.32-42
Hauptverfasser:	Wu, Meng, Li, Hong, Liu, Ran, Gao, Xiangqian, Zhang, Menghua, Liu, Pengxing, Fu, Zheng, Yang, Jinna, Zhang-Negrerie, Daisy, Gao, Qingzhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor efficacy Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Colon - drug effects Colon - metabolism Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Galactose - chemistry Galactose - pharmacology Galactose - therapeutic use Galactose-Pt(II) conjugate Glucose Transport Proteins, Facilitative - metabolism Glucose transporter Glycolysis - drug effects HT29 Cells Humans Lung - drug effects Lung - metabolism Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Male Maximum tolerated dose Mice, Inbred BALB C Mice, Nude Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Organoplatinum Compounds - therapeutic use Warburg effect
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