High dose of formaldehyde exposure during pregnancy increases neutrophils lung influx evoked by ovalbumin in the offspring
Objective Considering that asthma might have their onset in the intrauterine life and the exposure to FA during pregnancy interferes in the immune system of offspring, here we hypothesized that high dose of FA exposure during pregnancy could to contribute for development and severity of asthma in th...
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| Veröffentlicht in: | Inflammation research 2016-03, Vol.65 (3), p.179-181 |
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| container_title | Inflammation research |
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| creator | Maiellaro, Marília Macedo, Rodrigo Silva Mendes, Eduardo Tavares-de-Lima, Wothan Ferreira, Caroline Marcantonio Lino-dos-Santos-Franco, Adriana |
| description | Objective
Considering that asthma might have their onset in the intrauterine life and the exposure to FA during pregnancy interferes in the immune system of offspring, here we hypothesized that high dose of FA exposure during pregnancy could to contribute for development and severity of asthma in the offspring.
Methods
Pregnant Wistar rats were submitted to FA inhalation (6.13 mg/m
3
, 1 h/day, 5 days/week, for 21 days) or vehicle (distillated water). After 30 days of birth, the offspring was sensitized with ovalbumin (OVA)-alum and challenged with aerosolized OVA (1 %, 15 min, 3 days). After 24 h the OVA challenge, the analyses were performed. Non-manipulated rats were used as basal parameters.
Results
Our data show that the exposure to high dose of FA during pregnancy predisposes the development of neutrophilic lung inflammation in the offspring, as observed by the profile of cells and cytokines in the lung.
Conclusion
This study contributes to the understanding of effects of pollution on the development of lung diseases. |
| doi_str_mv | 10.1007/s00011-015-0901-2 |
| format | Article |
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Considering that asthma might have their onset in the intrauterine life and the exposure to FA during pregnancy interferes in the immune system of offspring, here we hypothesized that high dose of FA exposure during pregnancy could to contribute for development and severity of asthma in the offspring.
Methods
Pregnant Wistar rats were submitted to FA inhalation (6.13 mg/m
3
, 1 h/day, 5 days/week, for 21 days) or vehicle (distillated water). After 30 days of birth, the offspring was sensitized with ovalbumin (OVA)-alum and challenged with aerosolized OVA (1 %, 15 min, 3 days). After 24 h the OVA challenge, the analyses were performed. Non-manipulated rats were used as basal parameters.
Results
Our data show that the exposure to high dose of FA during pregnancy predisposes the development of neutrophilic lung inflammation in the offspring, as observed by the profile of cells and cytokines in the lung.
Conclusion
This study contributes to the understanding of effects of pollution on the development of lung diseases.</description><identifier>ISSN: 1023-3830</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/s00011-015-0901-2</identifier><identifier>PMID: 26608501</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Allergology ; Alum Compounds ; Animals ; Asthma - immunology ; Biomedical and Life Sciences ; Biomedicine ; Bronchoalveolar Lavage Fluid - cytology ; Bronchoalveolar Lavage Fluid - immunology ; Dermatology ; Female ; Formaldehyde - toxicity ; Immunology ; Lung - drug effects ; Lung - immunology ; Maternal-Fetal Exchange ; Neurology ; Neutrophils - drug effects ; Ovalbumin ; Pharmacology/Toxicology ; Pregnancy ; Prenatal Exposure Delayed Effects ; Rats, Wistar ; Rheumatology ; Short Communication</subject><ispartof>Inflammation research, 2016-03, Vol.65 (3), p.179-181</ispartof><rights>Springer International Publishing 2015</rights><rights>Springer International Publishing 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-cac1c7c6d34dbe2361a954d327fdac0bd98c8b648ce461c4e026d1ff9de1f4ff3</citedby><cites>FETCH-LOGICAL-c442t-cac1c7c6d34dbe2361a954d327fdac0bd98c8b648ce461c4e026d1ff9de1f4ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00011-015-0901-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00011-015-0901-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26608501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maiellaro, Marília</creatorcontrib><creatorcontrib>Macedo, Rodrigo Silva</creatorcontrib><creatorcontrib>Mendes, Eduardo</creatorcontrib><creatorcontrib>Tavares-de-Lima, Wothan</creatorcontrib><creatorcontrib>Ferreira, Caroline Marcantonio</creatorcontrib><creatorcontrib>Lino-dos-Santos-Franco, Adriana</creatorcontrib><title>High dose of formaldehyde exposure during pregnancy increases neutrophils lung influx evoked by ovalbumin in the offspring</title><title>Inflammation research</title><addtitle>Inflamm. Res</addtitle><addtitle>Inflamm Res</addtitle><description>Objective
Considering that asthma might have their onset in the intrauterine life and the exposure to FA during pregnancy interferes in the immune system of offspring, here we hypothesized that high dose of FA exposure during pregnancy could to contribute for development and severity of asthma in the offspring.
Methods
Pregnant Wistar rats were submitted to FA inhalation (6.13 mg/m
3
, 1 h/day, 5 days/week, for 21 days) or vehicle (distillated water). After 30 days of birth, the offspring was sensitized with ovalbumin (OVA)-alum and challenged with aerosolized OVA (1 %, 15 min, 3 days). After 24 h the OVA challenge, the analyses were performed. Non-manipulated rats were used as basal parameters.
Results
Our data show that the exposure to high dose of FA during pregnancy predisposes the development of neutrophilic lung inflammation in the offspring, as observed by the profile of cells and cytokines in the lung.
Conclusion
This study contributes to the understanding of effects of pollution on the development of lung diseases.</description><subject>Allergology</subject><subject>Alum Compounds</subject><subject>Animals</subject><subject>Asthma - immunology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Bronchoalveolar Lavage Fluid - immunology</subject><subject>Dermatology</subject><subject>Female</subject><subject>Formaldehyde - toxicity</subject><subject>Immunology</subject><subject>Lung - drug effects</subject><subject>Lung - immunology</subject><subject>Maternal-Fetal Exchange</subject><subject>Neurology</subject><subject>Neutrophils - drug effects</subject><subject>Ovalbumin</subject><subject>Pharmacology/Toxicology</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Rats, Wistar</subject><subject>Rheumatology</subject><subject>Short Communication</subject><issn>1023-3830</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUFrFTEQxxdRbG39AF4k4MXL2kk2m80epVQrFLxU6C1kk8l7W3eTNXkpfX56s2wVETxlIL_5TzK_qnpD4QMF6C4SAFBaA21r6IHW7Fl1SjmDugd597zUwJq6kQ2cVK9Sui-0ZJK9rE6YECBboKfVz-txtyc2JCTBERfirCeL-6NFgo9LSDkisTmOfkeWiDuvvTmS0ZuIOmEiHvMhhmU_TolMuUCjd1N-JPgQvqMlw5GEBz0NeR59uSKH_TrGpWUNPK9eOD0lfP10nlXfPl3dXl7XN18_f7n8eFMbztmhNtpQ0xlhG24HZI2gum-5bVjnrDYw2F4aOQguDXJBDUdgwlLneovUceeas-r9lrvE8CNjOqh5TAanSXsMOSnaibaVQLu2oO_-Qe9Djr68bqV434LgrFB0o0wMKUV0qvxn1vGoKKhVjNrEqCJGrWLU2vP2KTkPM9o_Hb9NFIBtwLYcjH-N_m_qL6Zjm2k</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Maiellaro, Marília</creator><creator>Macedo, Rodrigo Silva</creator><creator>Mendes, Eduardo</creator><creator>Tavares-de-Lima, Wothan</creator><creator>Ferreira, Caroline Marcantonio</creator><creator>Lino-dos-Santos-Franco, Adriana</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160301</creationdate><title>High dose of formaldehyde exposure during pregnancy increases neutrophils lung influx evoked by ovalbumin in the offspring</title><author>Maiellaro, Marília ; Macedo, Rodrigo Silva ; Mendes, Eduardo ; Tavares-de-Lima, Wothan ; Ferreira, Caroline Marcantonio ; Lino-dos-Santos-Franco, Adriana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-cac1c7c6d34dbe2361a954d327fdac0bd98c8b648ce461c4e026d1ff9de1f4ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Allergology</topic><topic>Alum Compounds</topic><topic>Animals</topic><topic>Asthma - immunology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>Bronchoalveolar Lavage Fluid - immunology</topic><topic>Dermatology</topic><topic>Female</topic><topic>Formaldehyde - toxicity</topic><topic>Immunology</topic><topic>Lung - drug effects</topic><topic>Lung - immunology</topic><topic>Maternal-Fetal Exchange</topic><topic>Neurology</topic><topic>Neutrophils - drug effects</topic><topic>Ovalbumin</topic><topic>Pharmacology/Toxicology</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Rats, Wistar</topic><topic>Rheumatology</topic><topic>Short Communication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maiellaro, Marília</creatorcontrib><creatorcontrib>Macedo, Rodrigo Silva</creatorcontrib><creatorcontrib>Mendes, Eduardo</creatorcontrib><creatorcontrib>Tavares-de-Lima, Wothan</creatorcontrib><creatorcontrib>Ferreira, Caroline Marcantonio</creatorcontrib><creatorcontrib>Lino-dos-Santos-Franco, Adriana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maiellaro, Marília</au><au>Macedo, Rodrigo Silva</au><au>Mendes, Eduardo</au><au>Tavares-de-Lima, Wothan</au><au>Ferreira, Caroline Marcantonio</au><au>Lino-dos-Santos-Franco, Adriana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High dose of formaldehyde exposure during pregnancy increases neutrophils lung influx evoked by ovalbumin in the offspring</atitle><jtitle>Inflammation research</jtitle><stitle>Inflamm. Res</stitle><addtitle>Inflamm Res</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>65</volume><issue>3</issue><spage>179</spage><epage>181</epage><pages>179-181</pages><issn>1023-3830</issn><eissn>1420-908X</eissn><abstract>Objective
Considering that asthma might have their onset in the intrauterine life and the exposure to FA during pregnancy interferes in the immune system of offspring, here we hypothesized that high dose of FA exposure during pregnancy could to contribute for development and severity of asthma in the offspring.
Methods
Pregnant Wistar rats were submitted to FA inhalation (6.13 mg/m
3
, 1 h/day, 5 days/week, for 21 days) or vehicle (distillated water). After 30 days of birth, the offspring was sensitized with ovalbumin (OVA)-alum and challenged with aerosolized OVA (1 %, 15 min, 3 days). After 24 h the OVA challenge, the analyses were performed. Non-manipulated rats were used as basal parameters.
Results
Our data show that the exposure to high dose of FA during pregnancy predisposes the development of neutrophilic lung inflammation in the offspring, as observed by the profile of cells and cytokines in the lung.
Conclusion
This study contributes to the understanding of effects of pollution on the development of lung diseases.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>26608501</pmid><doi>10.1007/s00011-015-0901-2</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1023-3830 |
| ispartof | Inflammation research, 2016-03, Vol.65 (3), p.179-181 |
| issn | 1023-3830 1420-908X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1765580175 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Allergology Alum Compounds Animals Asthma - immunology Biomedical and Life Sciences Biomedicine Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Dermatology Female Formaldehyde - toxicity Immunology Lung - drug effects Lung - immunology Maternal-Fetal Exchange Neurology Neutrophils - drug effects Ovalbumin Pharmacology/Toxicology Pregnancy Prenatal Exposure Delayed Effects Rats, Wistar Rheumatology Short Communication |
| title | High dose of formaldehyde exposure during pregnancy increases neutrophils lung influx evoked by ovalbumin in the offspring |
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