Ligand-based modeling of diverse aryalkylamines yields new potent P-glycoprotein inhibitors

The P-glycoprotein (P-gp) efflux pump has an important role as a natural detoxification system in many types of normal and cancer cells. P-gp is implicated in multiple drug resistance (MDR) exhibited by several types of cancer against a multitude of anticancer chemotherapeutic agents, and therefore,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2016-03, Vol.110, p.204-223
Hauptverfasser:	AlQudah, Dana A., Zihlif, Malek A., Taha, Mutasem O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alkylation Amines - chemistry Amines - pharmacology Antineoplastic Agents - pharmacology ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Cell Line, Tumor Doxorubicin - pharmacology Doxorubicin-resistant cells Drug Design Drug Resistance, Neoplasm - drug effects Humans Hydrocarbons, Aromatic - chemistry Hydrocarbons, Aromatic - pharmacology Ligands Models, Molecular P-glycoprotein Pharmacophore QSAR Quantitative Structure-Activity Relationship ROC Curve Virtual screening
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!