Prolonged norovirus infection after pancreas transplantation: a case report and review of chronic norovirus
Norovirus is a major cause of self‐limited gastroenteritis worldwide. Prevention and treatment are thwarted by rapid viral evolution, and thus supportive care remains the mainstay of therapy. Chronic infection in immunocompromised hosts is increasingly described. We report a case of norovirus infect...
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| Veröffentlicht in: | Transplant infectious disease 2016-02, Vol.18 (1), p.98-104 |
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| creator | Echenique, I.A. Stosor, V. Gallon, L. Kaufman, D. Qi, C. Zembower, T.R. |
| description | Norovirus is a major cause of self‐limited gastroenteritis worldwide. Prevention and treatment are thwarted by rapid viral evolution, and thus supportive care remains the mainstay of therapy. Chronic infection in immunocompromised hosts is increasingly described. We report a case of norovirus infection lasting 2543 days in a pancreas transplant recipient. Serial fecal specimens were obtained, from which a map of genetic relatedness was derived. The clinical course was complicated by renal failure that progressed to end‐stage renal disease. Minimization of immunosuppression was associated with resolution of the infection. Subsequently, the patient experienced a suspected allograft rejection that did not compromise pancreas function. The patient later underwent living‐related renal transplantation without recurrence of enteritis. |
| doi_str_mv | 10.1111/tid.12472 |
| format | Article |
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Prevention and treatment are thwarted by rapid viral evolution, and thus supportive care remains the mainstay of therapy. Chronic infection in immunocompromised hosts is increasingly described. We report a case of norovirus infection lasting 2543 days in a pancreas transplant recipient. Serial fecal specimens were obtained, from which a map of genetic relatedness was derived. The clinical course was complicated by renal failure that progressed to end‐stage renal disease. Minimization of immunosuppression was associated with resolution of the infection. Subsequently, the patient experienced a suspected allograft rejection that did not compromise pancreas function. The patient later underwent living‐related renal transplantation without recurrence of enteritis.</description><identifier>ISSN: 1398-2273</identifier><identifier>EISSN: 1399-3062</identifier><identifier>DOI: 10.1111/tid.12472</identifier><identifier>PMID: 26460906</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Caliciviridae Infections - complications ; Caliciviridae Infections - virology ; chronic diarrhea ; Chronic Disease ; colitis ; diarrhea ; end‐stage renal disease ; Female ; gastroenteritis ; Gastroenteritis - complications ; Gastroenteritis - virology ; Graft Rejection ; Humans ; Immunocompromised Host ; Immunosuppression - adverse effects ; Infections ; Kidney Failure, Chronic - complications ; Middle Aged ; norovirus ; Norovirus - genetics ; Norovirus - isolation & purification ; organ rejection ; Pancreas ; pancreas transplant ; Pancreas Transplantation - adverse effects ; solid organ transplantation ; Transplants & implants</subject><ispartof>Transplant infectious disease, 2016-02, Vol.18 (1), p.98-104</ispartof><rights>2015 John Wiley & Sons A/S. 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Prevention and treatment are thwarted by rapid viral evolution, and thus supportive care remains the mainstay of therapy. Chronic infection in immunocompromised hosts is increasingly described. We report a case of norovirus infection lasting 2543 days in a pancreas transplant recipient. Serial fecal specimens were obtained, from which a map of genetic relatedness was derived. The clinical course was complicated by renal failure that progressed to end‐stage renal disease. Minimization of immunosuppression was associated with resolution of the infection. Subsequently, the patient experienced a suspected allograft rejection that did not compromise pancreas function. The patient later underwent living‐related renal transplantation without recurrence of enteritis.</description><subject>Caliciviridae Infections - complications</subject><subject>Caliciviridae Infections - virology</subject><subject>chronic diarrhea</subject><subject>Chronic Disease</subject><subject>colitis</subject><subject>diarrhea</subject><subject>end‐stage renal disease</subject><subject>Female</subject><subject>gastroenteritis</subject><subject>Gastroenteritis - complications</subject><subject>Gastroenteritis - virology</subject><subject>Graft Rejection</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Immunosuppression - adverse effects</subject><subject>Infections</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Middle Aged</subject><subject>norovirus</subject><subject>Norovirus - genetics</subject><subject>Norovirus - isolation & purification</subject><subject>organ rejection</subject><subject>Pancreas</subject><subject>pancreas transplant</subject><subject>Pancreas Transplantation - adverse effects</subject><subject>solid organ transplantation</subject><subject>Transplants & implants</subject><issn>1398-2273</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLLDEQRoMovhf-AQm40UVrHj3pzt2JbxB0oeumJl3xRnuSvkn3iP_eOKNXEKxNFdThUNRHyB5nxzzXyeDaYy7KSqyQTS61LiRTYnUx14UQldwgWyk9M8YrXep1siFUqZhmapO83MfQBf-ELfUhhrmLY6LOWzSDC56CHTDSHryJCIkOEXzqO_ADfKz_UKAGEtKIfYgDBd_mce7wlQZLzd8YvDPf3h2yZqFLuPvZt8nj5cXD2XVxe3d1c3Z6Wxg5kaIoVVu3uhVSYY0aBFPWKuRGIJOi0rWBGoWaaNR6KksFiKXmFnFqERhYkNvkcOntY_g3YhqamUsGu3w3hjE1vFKTSf5EpTN68AN9DmP0-boFxaqyYipTR0vKxJBSRNv00c0gvjWcNR8JNDmBZpFAZvc_jeN0hu1_8uvlGThZAq-uw7ffTc3DzflS-Q50E5Hh</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Echenique, I.A.</creator><creator>Stosor, V.</creator><creator>Gallon, L.</creator><creator>Kaufman, D.</creator><creator>Qi, C.</creator><creator>Zembower, T.R.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6301-0121</orcidid></search><sort><creationdate>201602</creationdate><title>Prolonged norovirus infection after pancreas transplantation: a case report and review of chronic norovirus</title><author>Echenique, I.A. ; 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Prevention and treatment are thwarted by rapid viral evolution, and thus supportive care remains the mainstay of therapy. Chronic infection in immunocompromised hosts is increasingly described. We report a case of norovirus infection lasting 2543 days in a pancreas transplant recipient. Serial fecal specimens were obtained, from which a map of genetic relatedness was derived. The clinical course was complicated by renal failure that progressed to end‐stage renal disease. Minimization of immunosuppression was associated with resolution of the infection. Subsequently, the patient experienced a suspected allograft rejection that did not compromise pancreas function. The patient later underwent living‐related renal transplantation without recurrence of enteritis.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>26460906</pmid><doi>10.1111/tid.12472</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6301-0121</orcidid></addata></record> |
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| ispartof | Transplant infectious disease, 2016-02, Vol.18 (1), p.98-104 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Caliciviridae Infections - complications Caliciviridae Infections - virology chronic diarrhea Chronic Disease colitis diarrhea end‐stage renal disease Female gastroenteritis Gastroenteritis - complications Gastroenteritis - virology Graft Rejection Humans Immunocompromised Host Immunosuppression - adverse effects Infections Kidney Failure, Chronic - complications Middle Aged norovirus Norovirus - genetics Norovirus - isolation & purification organ rejection Pancreas pancreas transplant Pancreas Transplantation - adverse effects solid organ transplantation Transplants & implants |
| title | Prolonged norovirus infection after pancreas transplantation: a case report and review of chronic norovirus |
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