Relative Involvement of Spinal Opioid Receptors in Physical Dependence on Intrathecal Butorphanol and Morphine

The present study was carried out to investigate the relative involvement of spinal opioid receptors in the development of physical dependence on intrathecal (IT) butorphanol in comparison with IT morphine. Dependence was induced by continuous IT infusion of butorphanol (52 nmol/h) and morphine (26...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1998-08, Vol.60 (4), p.899-907
Hauptverfasser:	Wongchanapai, W., Tsang, B.K., He, Z., Ho, I.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Butorphanol Butorphanol - administration & dosage Drug toxicity and drugs side effects treatment Injections, Spinal Intrathecal Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Morphine Morphine - administration & dosage Morphine Dependence - physiopathology Narcotic Antagonists - administration & dosage Narcotic Antagonists - pharmacology Narcotics - administration & dosage Opioid-Related Disorders - physiopathology Pharmacology. Drug treatments Physical dependence Rats Rats, Sprague-Dawley Receptors, Opioid - drug effects Spinal Cord - physiology Substance Withdrawal Syndrome - psychology
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